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Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and insulin resistance in an American ...

Published in Journal of diabetes investigation

Previous studies have demonstrated a correlation between the serum uric acid-to-high-density lipoprotein cholesterol ratio (UHR) and insulin resistance (IR) in individuals with type 2 diabetes mellitus. However, no existing studies have investigated the relationship between IR and UHR in the general population. Therefore, the primary objective of t...

High glucose promotes atherosclerosis by regulating miRNA let7d-5p level.

Published in Journal of diabetes investigation

MiRNA let7d-5p has been recently reported to be abnormally expressed in diabetes-associated atherosclerosis (AS). However, it still remains unknown how let7d-5p contributes to the process of atherosclerosis. Twenty fresh tissues and a total of 28 wax block specimens from carotid endarterectomy procedures were obtained from the Luoyang Central Hospi...

Health impacts of new-onset diabetes in women post-gestational diabetes mellitus: Insights from Hong Kong's territory-wi...

Published in Journal of diabetes investigation

To determine the population health burden attributable to the development of diabetes among women with a history of gestational diabetes mellitus (GDM). We conducted a retrospective analysis of women with a history of GDM attending the Hong Kong Hospital Authority between 2000 and 2019. The time-varying population attributable fraction was calculat...

Interplay of cardiovascular health and diabetes: Insights into weight management and risk reduction.

Published in Journal of diabetes investigation

Glucose metabolism partially regulates β-cell function through epigenomic changes.

Published in Journal of diabetes investigation

The β-cell relies predominantly on glucose utilization to generate adenosine triphosphate, which is crucial for both cell viability and insulin secretion. The β-cell has evolved remarkable metabolic flexibility to productively respond to shifts in environmental conditions and changes in glucose availability. Although these adaptive responses are im...

Fulminant type 1 diabetes, an underrecognized and unique subtype of type 1 diabetes: A case series from Singapore.

Published in Journal of diabetes investigation

Fulminant type 1 diabetes (FT1D) is a unique subtype of type 1 diabetes, characterized by acute absolute insulin deficiency, severe ketosis, and increased risk of hypoglycemia, glycemic variability and microvascular complications. Seven people with FT1D were identified from two tertiary centers in Singapore. Six were Chinese, the mean age was 35 ye...

Role of β-cell autophagy in β-cell physiology and the development of diabetes.

Published in Journal of diabetes investigation

Elucidating the molecular mechanism of autophagy was a landmark in understanding not only the physiology of cells and tissues, but also the pathogenesis of diverse diseases, including diabetes and metabolic disorders. Autophagy of pancreatic β-cells plays a pivotal role in the maintenance of the mass, structure and function of β-cells, whose dysreg...

Simplified electrophysiological approach combining a point-of-care nerve conduction device and an electrocardiogram prod...

Published in Journal of diabetes investigation

This study aimed to investigate the diagnostic potential of two simplified tests, a point-of-care nerve conduction device (DPNCheck™) and a coefficient of variation of R-R intervals (CVR-R), as an alternative to traditional nerve conduction studies for the diagnosis of diabetic polyneuropathy (DPN) in patients with diabetes. Inpatients with type 1 ...

Corticosteroid-triggered acute skeletal muscle loss in lipodystrophy: A case report.

Published in Journal of diabetes investigation

The potential liability to hypercatabolism in lipodystrophy remains to be fully elucidated. Here we report a 28-year-old Japanese woman with acquired generalized lipodystrophy, who presented with recurrence of panniculitis and anemia. After corticosteroid treatment was started, she showed rapid reductions in body weight and lean mass by 15% at maxi...

Performance of different machine learning algorithms in identifying undiagnosed diabetes based on nonlaboratory paramete...

Published in Journal of diabetes investigation

Machine learning algorithms based on the artificial neural network (ANN), support vector machine, naive Bayesian or logistic regression model are commonly used to identify diabetes. This study investigated which approach performed the best and whether muscle strength provided any incremental benefit in identifying undiagnosed diabetes in Chinese ad...