Fernandes, Mário Lopes, Ivo Magalhães, Luana Sárria, Marisa P Machado, Raul Sousa, João Carlos Botelho, Cláudia Teixeira, José Gomes, Andreia C
Published in
Journal of controlled release : official journal of the Controlled Release Society
Exosomes are cell-derived vesicles that act as carriers for proteins and nucleic acids, with therapeutic potential and high biocompatibility. We propose a new concept of exosome-like liposomes for controlled delivery. The goal of this work was to develop a new type of liposomes with a unique mixture of phospholipids, similar to naturally occurring ...
Halamoda-Kenzaoui, B Vandebriel, R J Howarth, A Siccardi, M David, C A W Liptrott, N J Santin, M Borgos, S E Bremer-Hoffman, S Caputo, F
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
Nanotechnology-based health products are providing innovative solutions in health technologies and the pharmaceutical field, responding to unmet clinical needs. However, suitable standardised methods need to be available for the assessment of quality and safety of these innovative products prior to their translation into the clinic and for monitori...
Ditani, Aayushi S Mallick, Pragyan Paramita Anup, Neelima Tambe, Vishakha Polaka, Suryanarayana Sengupta, Pinaki Rajpoot, Kuldeep Tekade, Rakesh K
Published in
Journal of controlled release : official journal of the Controlled Release Society
Biosimilars are the biological product clinically identical to a biologic reference standard regarding their strength, purity, and safety. A large segment of biosimilars has been developed for the treatment of cancer. This review aims to discuss various facets of biosimilars and explicates on biosimilars accessible in the market for cancer clinical...
O'Brien, Matthew N Jiang, Wenlei Wang, Yan Loffredo, David M
Published in
Journal of controlled release : official journal of the Controlled Release Society
Long-acting injectable (LAI) drug products enable the controlled release of a drug over an extended duration of time to improve the therapeutic effect, safety profile, or administration of an injectable product. The development of generic [505(j)] and differentiated [505(b)(2)] LAI products helps to provide patients and healthcare providers with mo...
Pallarès, Victor Núñez, Yáiza Sánchez-García, Laura Falgàs, Aïda Serna, Naroa Unzueta, Ugutz Gallardo, Alberto Alba-Castellón, Lorena Álamo, Patricia Sierra, Jorge
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
Nanomedicine has opened an opportunity to improve current clinical practice by enhancing the selectivity in the delivery of antitumor drugs to specific cancer cells. These new strategies are able to bypass toxicity on normal cells increasing the effectiveness of current anticancer treatments. In acute myeloid leukemia (AML) current chemotherapy tre...
Li, Yuanyuan Xiong, Jianming Guo, Wenjing Jin, Yangye Miao, Wenjun Wang, Cong Zhang, Hongman Hu, Yi Huang, He
Published in
Journal of controlled release : official journal of the Controlled Release Society
Novel platforms for cisplatin delivery with a controllable manner and combinable with other treatment modality to achieve synergistic antitumor effect and inhibition metastasis for treatment of triple negative breast cancer (TNBC) are highly desirable. Herein, we report a black phosphorus (BP) nanosheets-based nano-assembly which consists of cispla...
Liu, Shangui Khan, Abdur Rauf Yang, Xiaoye Dong, Bo Ji, Jianbo Zhai, Guangxi
Published in
Journal of controlled release : official journal of the Controlled Release Society
Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists have considered the overexpressed efflux transporters responsible for MDR and chemotherapy failure. MDR extremely limits the therapeutic effect of chemotherapy in cancer treatment. Many strategies have been applied to solve this problem. Multifunctional nanopar...
Liu, Jianping Liu, Kai Zhang, Liming Zhong, Ming Hong, Tingliang Zhang, Run Gao, Yufan Li, Rui Xu, Tiefeng Xu, Zhi Ping
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
Considerable attention has been devoted to nanomedicine development for breast cancer therapy, while the therapeutic efficiency is far from satisfactory owing to non-specific biodistribution-caused side effects and limitation of single modal treatment. In this study, we have developed a novel nanomedicine for efficient combination breast cancer the...
Brunato, Silvia Mastrotto, Francesca Bellato, Federica Bastiancich, Chiara Travanut, Alessandra Garofalo, Mariangela Mantovani, Giuseppe Alexander, Cameron Preat, Veronique Salmaso, Stefano
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
A library of amphiphilic monomethoxypolyethylene glycol (mPEG) terminating polyaminoacid co-polymers able to self-assemble into colloidal systems was screened for the delivery and controlled release of doxorubicin (Doxo). mPEG-Glu/Leu random co-polymers were generated by Ring Opening Polymerization from 5 kDa mPEG-NH2 macroinitiator using 16:0:1, 8...
Zhi, Defu Yang, Ting Zhang, Tingyu Yang, Mei Zhang, Shubiao Donnelly, Ryan F
Published in
Journal of controlled release : official journal of the Controlled Release Society
The success of skin cancer treatment is severely limited in the route of administration because most genes and drugs cannot break through the excellent stratum corneum (SC) barrier of the skin, leading to their inability to reach the tumor tissues at therapeutic doses. As an excellent minimally invasive delivery method, microneedles (MNs) can bypas...
