Zhang, Yiwen Jiang, Chen
Published in
Journal of controlled release : official journal of the Controlled Release Society
The keys to the prevention of tumor recurrence after operation are the elimination of residual tumor cells and the reversal of microenvironments that induce recurrence. In the formulation of a treatment scheme, building an appropriate drug delivery system is essential. An in-situ drug delivery system (ISDDS) is regarded as an effective treatment ro...
Chen, Yun-Chu Gad, Sheryhan F Chobisa, Dhawal Li, Yongzhe Yeo, Yoon
Published in
Journal of controlled release : official journal of the Controlled Release Society
Inflammation that is not resolved in due course becomes a chronic disease. The treatment of chronic inflammatory diseases involves a long-term use of anti-inflammatory drugs such as corticosteroids and nonsteroidal anti-inflammatory drugs, often accompanied by dose-dependent side effects. Local drug delivery systems have been widely explored to red...
Ameena Shirin, V K Sankar, Renu Johnson, Asha P Gangadharappa, H V Pramod, K
Published in
Journal of controlled release : official journal of the Controlled Release Society
Layered double hydroxides (LDHs), also known as anionic clays or hydrotalcite-like compounds, are a class of nanomaterials that attained great attention as a carrier for drug delivery applications. The lamellar structure of this compound exhibits a high surface-to-volume ratio which enables the intercalation of therapeutic agents and releases them ...
Wang, Shuo Liu, Zengyi Tong, Yue Zhai, Yunqian Zhao, Xiujie Yue, Xinmin Qiao, Yanqi Liu, Yonghui Yin, Yongmei Xi, Rimo
...
Published in
Journal of controlled release : official journal of the Controlled Release Society
As a photosensitizer with effective photothermal (PTT) and photodynamic (PDT) response, IR780 has been widely explored as promising cancer phototheranostic molecule. However, the systematic administration of IR780 usually suffers from poor water solubility and low photostability, so that it cannot be administrated by parenteral route. In this study...
Fertahi, Saloua Ilsouk, Mohamed Zeroual, Youssef Oukarroum, Abdallah Barakat, Abdellatif
Published in
Journal of controlled release : official journal of the Controlled Release Society
The growth of the human population is causing an exponential increase in the need for food. Fertilizers are one of the most important elements to meet this increased demand and to ensure global food security. Many enhanced efficiency fertilizers, such as controlled-release fertilizers (CRFs) have been developed. Although these fertilizers offer man...
Zhang, Zui Chu, Yuxiu Li, Cheng Tang, Wenjing Qian, Jun Wei, Xiaoli Lu, Weiyue Ying, Tianlei Zhan, Changyou
Published in
Journal of controlled release : official journal of the Controlled Release Society
Anti-PEG antibodies have been witnessed in patients and experimental animals, accelerating the blood clearance (termed ABC phenomenon) of PEGylated nanomedicines by activating complement after absorption on the nano-surface. The ABC phenomenon presents an obstacle to the clinical translation of PEGylated nanomedicines. Herein, an anti-PEG single-ch...
Yoshinaga, Naoto Uchida, Satoshi Dirisala, Anjaneyulu Naito, Mitsuru Osada, Kensuke Cabral, Horacio Kataoka, Kazunori
Published in
Journal of controlled release : official journal of the Controlled Release Society
Carriers for messenger RNA (mRNA) delivery require propensities to protect the mRNA from enzymatic degradation and to selectively release mRNA in the cytosol for smooth mRNA translation. To meet these requirements, we designed mRNA-loaded polyplex micelles (PMs) with ATP-responsive crosslinking in the inner core by complexing mRNA with poly(ethylen...
Wu, Yina Li, Qiaoyun Shim, Gayong Oh, Yu-Kyoung
Published in
Journal of controlled release : official journal of the Controlled Release Society
Photothermal immunotherapy has emerged as one of the most potent approaches for cancer treatment, but this strategy has suffered from the lack of biodegradability of the photoresponsive materials. In this study, we aimed to develop biodegradable materials for photothermal immunotherapy. To this end, we designed a DNA CpG hydrogel (DH, generated by ...
Gadekar, Vedant Borade, Yogeshwari Kannaujia, Suraj Rajpoot, Kuldeep Anup, Neelima Tambe, Vishakha Kalia, Kiran Tekade, Rakesh K
Published in
Journal of controlled release : official journal of the Controlled Release Society
Nanomedicines refers to nanotechnology inspired pharmaceutical products often referred to as 'nanopharmaceuticals.' It has displayed commendable potential in enhancing therapeutic efficacy as well as in reducing the side effects associated with conventional drug counterpart. Recent years have monitored the entry of a large amount of nanomedicine in...
Takenaka, Tomoka Sakamoto, Wakako Takahashi, Shutaro Shimada, Naohiko Maruyama, Atsushi
Published in
Journal of controlled release : official journal of the Controlled Release Society
Controlled or targeted membrane lysis induced by cascades of assembly and activation of biomolecules on membrane surfaces is important in programmed cell death and host defense systems. In a previous study, we reported that an ionic graft copolymer with a polycation backbone and water-soluble graft chains, poly(allylamine)-graft-dextran (PAA-g-Dex)...
