Roovers, S Deprez, J Priwitaningrum, D Lajoinie, G Rivron, N Declercq, H De Wever, O Stride, E Le Gac, S Versluis, M
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Published in
Journal of controlled release : official journal of the Controlled Release Society
Ultrasound-triggered drug-loaded microbubbles have great potential for drug delivery due to their ability to locally release drugs and simultaneously enhance their delivery into the target tissue. We have recently shown that upon applying ultrasound, nanoparticle-loaded microbubbles can deposit nanoparticles onto cells grown in 2D monolayers, throu...
Wang, Zhenjie Chi, Dongxu Wu, Xingchen Wang, Yingli Lin, Xinxin Xu, Zhaochu Liu, Hongzhuo Sun, Jin He, Zhonggui Wang, Yongjun
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Published in
Journal of controlled release : official journal of the Controlled Release Society
As the demand for nutrients in malignant proliferation of tumors increases, the L-type amino acid transporter 1(LAT1) and amino acid transporter B0,+ (ATB0,+) of tumor cells are more highly expressed than normal cells which can be used as new targets for active targeting of cancer. However, drug delivery systems often require multi-target design to...
Mulholland, Eoghan J Ali, Ahlam Robson, Tracy Dunne, Nicholas J McCarthy, Helen O
Published in
Journal of controlled release : official journal of the Controlled Release Society
FK506-binding protein-like (FKBPL) has previously been shown to inhibit angiogenesis via in vitro and in vivo experimentation. Thus, it was proposed that the delivery of a siRNA targeting FKBPL could hold great potential in promoting angiogenesis for advanced wound healing applications. An effective delivery system has been utilised to encapsulate ...
Li, Xinfang Xu, Qinan Zhang, Peng Zhao, Xiao Wang, Youxiang
Published in
Journal of controlled release : official journal of the Controlled Release Society
Transdermal gene therapy is a useful treatment for many skin lesions. By penetrating stratum corneum directly, microneedle patch (MNP) has been widely investigated to improve transdermal gene delivery. However, considering the operability and patience compliance, quick gene release was required after insertion. In this research, by utilizing acidic...
Qiu, Yingshan Man, Rico C H Liao, Qiuying Kung, Keshia L K Chow, Michael Y T Lam, Jenny K W
Published in
Journal of controlled release : official journal of the Controlled Release Society
Pulmonary delivery of messenger RNA (mRNA) has considerable potential as therapy or vaccine for a range of lung diseases. Inhaled dry powder formulation of mRNA is particularly attractive as it has superior stability and dry powder inhaler is relatively easy to use. A safe and effective mRNA delivery vector as well as a suitable particle engineerin...
Yu, Minzhi Yuan, Wenmin Li, Dan Schwendeman, Anna Schwendeman, Steven P
Published in
Journal of controlled release : official journal of the Controlled Release Society
Dialysis methods are frequently used to determine the in vitro drug release kinetics of nanoparticle drug delivery systems. However, the need for the released drug to diffuse through the dialysis membrane delays its appearance in the sampling compartment. Thus, the apparent drug release data outside the dialysis bag typically does not match the des...
Bolli, Evangelia D'Huyvetter, Matthias Murgaski, Aleksandar Berus, Danielle Stangé, Geert Clappaert, Emile J Arnouk, Sana Pombo Antunes, Ana Rita Krasniqi, Ahmet Lahoutte, Tony
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Published in
Journal of controlled release : official journal of the Controlled Release Society
Radioimmunotherapy (RIT) aims to deliver a high radiation dose to cancer cells, while minimizing the exposure of normal cells. Typically, monoclonal antibodies are used to target the radionuclides to cancer cell surface antigens. However, antibodies face limitations due to their poor tumor penetration and suboptimal pharmacokinetics, while the expr...
Boyd, Peter Variano, Bruce Spence, Patrick McCoy, Clare F Murphy, Diarmaid J Dallal Bashi, Yahya H Malcolm, R Karl
Published in
Journal of controlled release : official journal of the Controlled Release Society
Drug-releasing vaginal rings are torus-shaped devices, generally fabricated from thermoplastic polymers or silicone elastomers, used to administer pharmaceutical drugs to the human vagina for periods typically ranging from three weeks to twelve months. One of the most important product performance tests for vaginal rings is the in vitro release tes...
Sager, Maximilian Grimm, Michael Aude, Philipp Schick, Philipp Merdivan, Simon Hasan, Mahmoud Kromrey, Marie-Luise Sivert, Aurélien Benameur, Hassan Koziolek, Mirko
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Published in
Journal of controlled release : official journal of the Controlled Release Society
The instability of various small molecules, vaccines and peptides in the human stomach is a complex challenge for oral drug delivery. Recently, a novel gastro-resistant capsule - the enTRinsic™ Drug Delivery Technology capsule - has been developed. In this work, the salivary tracer technique based on caffeine has been applied to study the in vivo d...
Shakya, Akhilesh Kumar Ingrole, Rohan S J Joshi, Gaurav Uddin, Md Jasim Anvari, Sara Davis, Carla M Gill, Harvinder Singh
Published in
Journal of controlled release : official journal of the Controlled Release Society
The prevalence of peanut allergies has escalated over the last 20 years, yet there are no FDA approved treatments for peanut allergies. In this study we evaluated the potential of microneedles to deliver peanut protein extract (PE) into skin and assessed if the ensuing immune responses could desensitize mice that were sensitized to peanuts. Peanut ...
