He, Huafeng Lin, Danmin Sun, Jiajie He, Xianying Wang, Tiantian Fang, Yinglin Fan, Kaixiang Chen, Xinxin Zhao, Suqing Zheng, Xi
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Published in
Journal of controlled release : official journal of the Controlled Release Society
The development of neuroprotective drugs has proven to be extremely difficult because of the blood-brain barrier. Intranasal administration is thought to transport the drug from the nasal cavity along the olfactory and trigeminal nerves to the brain, thus bypassing the blood-brain barrier. However, macromolecular protein drugs have low delivery eff...
Elechalawar, Chandra Kumar Hossen, M D Nazir McNally, Lacey Bhattacharya, Resham Mukherjee, Priyabrata
Published in
Journal of controlled release : official journal of the Controlled Release Society
When nanoparticles are introduced into biological systems, host proteins tend to associate on the particle surface to form a protein layer termed the "protein corona" (PC). Identifying the proteins that constitute the PC can yield useful information about nanoparticle processing, bio-distribution, toxicity and clearance. Similarly, characterizing a...
Gu, Xiao Song, Qingxiang Zhang, Qian Huang, Meng Zheng, Mengna Chen, Juan Wei, Dan Chen, Jun Wei, Xunbin Chen, Hongzhuan
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Published in
Journal of controlled release : official journal of the Controlled Release Society
The elaboration of nanotechnology offers valuable therapeutic options to overcome the blood-brain barrier and enable the treatment of brain diseases. However, to date, limit work has been done to reveal the fate of nanoparticles within the brain, which largely hinders their safe and effective applications. Here we demonstrated that the commonly-use...
Sun, Tao Zhang, Guangping Guo, Zhongyuan Chen, Qinjun Zhang, Yujie Chu, Yongchao Guo, Qin Li, Chao Zhou, Wenxi Zhang, Yiwen
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Published in
Journal of controlled release : official journal of the Controlled Release Society
Chelating Cu from tumors has been verified as an effective and promising strategy for cancer therapy through antiangiogenesis. However, systematic removal Cu by injecting with Cu chelators will result unavoidable side effects, since Cu is indispensable to the body. In this work, a micelle targeting to tumors' newborn vessels based on a polypeptide ...
Nguyen, Tiep Tien Emami, Fakhrossadat Yook, Simmyung Nguyen, Hanh Thuy Pham, Tung Thanh Pathak, Shiva Regmi, Shobha Kim, Jong Oh Yong, Chul Soon Kim, Jae-Ryong
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Published in
Journal of controlled release : official journal of the Controlled Release Society
Clinical intraportal pancreatic islet infusion is popular for treating type I diabetes. However, multiple doses of islets and anti-rejection protocols are needed to compensate for early large cell losses post-infusion due to the harsh hepatic environment. Thus, extrahepatic sites are utilized to enable efficient islet engraftment and reduce islet m...
Yang, Yang Ding, Yuan Fan, Bo Wang, Yi Mao, Zhengwei Wang, Weilin Wu, Jindan
Published in
Journal of controlled release : official journal of the Controlled Release Society
Sepsis is a complex disorder with very high morbidity and mortality; it can occur when an immune disorder triggers an invasion of pathogens in the host. Although many potential anti-infective and immunosuppressive treatments have been reported, we still do not have effective means of treating sepsis in clinic. The aim of this study is to develop a ...
Li, Yang Lin, Jinyan Cai, Zhixiong Wang, Peiyuan Luo, Qiang Yao, Cuiping Zhang, Yun Hou, Zhenqing Liu, Jingfeng Liu, Xiaolong
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Published in
Journal of controlled release : official journal of the Controlled Release Society
Carrier-free nanodrug via small-molecule assembly is a promising alternative strategy for tumor therapy. Thus, developing a self-recognizing carrier-free nanodrug without introduction of foreign ligand is very attractive to meet both targeting and therapeutic requirements while reducing structural complexity. Here we fabricated a tumor microenviron...
Shirai, Hiroaki Tsukada, Kosuke
Published in
Journal of controlled release : official journal of the Controlled Release Society
Motile bacteria are able to penetrate in the distal areas of blood vessel, which makes bacteria attractive to researchers as a drug delivery vehicle carrying anti-cancer drugs to tumors. Not only therapeutic bacteria show wide anti-tumor effect but also the combination of therapeutic bacteria and conventional chemotherapy leads to dramatically larg...
Farokhi, Mehdi Mottaghitalab, Fatemeh Reis, Rui L Ramakrishna, Seeram Kundu, Subhas C
Published in
Journal of controlled release : official journal of the Controlled Release Society
Electrospinning is well thought of as the most potent nanofiber producing technique, which is applicable in biomedical fields. The generation of electrospun nanofibers as drug carriers has widely been shown much interest over the past years. Electrospun nanofibers meet various advantages as drug delivery platforms including high surface area, accep...
Shen, Di Yu, Haojie Wang, Li Khan, Amin Haq, Fazal Chen, Xiang Huang, Qiao Teng, Lisong
Published in
Journal of controlled release : official journal of the Controlled Release Society
Diabetes, as a global threat nowadays, causes the wide usage of exogenous insulin. Subcutaneous injection is the traditional insulin administration in the diabetes treatments and is inconvenient and painful, which results in potential side effects of hypoglycemia. Scientists have made great efforts to develop alternatives. As the promising solution...
