Ji, Ping Chen, Jianmeng Golding, Amit Nikolov, Nikolay P Saluja, Bhawana Ren, Yunzhao R Sahajwalla, Chandrahas
Published in
Journal of clinical pharmacology
The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 600,000 deaths worldwide. Patients with severe disease often experience acute respiratory distress characterized by upregulation of multiple cytokines. Immunomodulatory biological therapies are being evaluated in clinical trials for the management of the systemic inflamm...
Ren, Yunzhao R Golding, Amit Sorbello, Alfred Ji, Ping Chen, Jianmeng Saluja, Bhawana Witzmann, Kimberly Arya, Vikram Reynolds, Kellie S Choi, Su-Young
...
Published in
Journal of clinical pharmacology
This literature review aims to provide a comprehensive current summary of the pathogenesis, clinical features, disease course, host immune responses, and current investigational antiviral and immunomodulatory pharmacotherapies to facilitate the development of future therapies and measures for prevention and control. Published 2020. This article is ...
Austin, Daren Okour, Malek
Published in
Journal of clinical pharmacology
Corral, Pablo Corral, Gonzalo Diaz, Rafael
Published in
Journal of clinical pharmacology
Nasiripour, Somayyeh Zamani, Farhad Farasatinasab, Maryam
Published in
Journal of clinical pharmacology
Dosne, Anne-Gaelle Valade, Elodie Stuyckens, Kim Li, Lilian Y Ouellet, Daniele Perez-Ruixo, Juan Jose
Published in
Journal of clinical pharmacology
A population pharmacokinetic (PK) model was developed using data pooled from 6 clinical studies (3 in healthy volunteers and 3 in cancer patients) to characterize total and free plasma concentrations of erdafitinib following single- and multiple-dose administration, to understand clinically relevant covariates, and to quantify the inter- and intrai...
Shuster, Diana L Shireman, Laura M Ma, Xiaosu Shen, Danny D Flood Nichols, Shannon K Ahmed, Mahmoud S Clark, Shannon Caritis, Steve Venkataramanan, Raman Haas, David M
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Published in
Journal of clinical pharmacology
Gestational diabetes mellitus is a condition similar to type 2 diabetes mellitus (T2DM) in that patients are unable to compensate for the degree of insulin resistance, and both conditions are often treated with metformin. The comparative pharmacodynamic response to metformin in these 2 populations has not been studied. This study characterized insu...
Greger, Jessica Bates, Vernice Mechtler, Laszlo Gengo, Fran
Published in
Journal of clinical pharmacology
Legalization of medical cannabis has occurred in 33 states and the District of Columbia, and recreational use has increased exponentially since 2013. As a result, it is important to understand how cannabis interacts with other drugs and has potential risks for patients on concomitant medications. Components of medical cannabis can inhibit or compet...
Malik, Paul R V Edginton, Andrea N
Published in
Journal of clinical pharmacology
An understanding of pediatric pharmacokinetics (PK) is essential for first-in-pediatric dose selection and clinical trial design. At present, there is no reliable way to scale the PK of monoclonal antibodies and immunoglobulin G drug products from adults to young children or to premature infants-a vulnerable population with a rapidly growing drug d...
Nader, Ahmed Stodtmann, Sven Friedel, Anna Mohamed, Mohamed-Eslam F Othman, Ahmed A
Published in
Journal of clinical pharmacology
Upadacitinib (ABT-494) is a selective Janus kinase (JAK)1 inhibitor being developed for treatment of several inflammatory disorders. A population pharmacokinetic model was developed for upadacitinib using 11,658 plasma concentrations from 1145 subjects from 4 phase 1 and 5 phase 2 studies in healthy subjects and subjects with rheumatoid arthritis, ...
