Poller, David Nigel Bongiovanni, Massimo Cochand-Priollet, Beatrix Johnson, Sarah J Perez-Machado, Miguel
Published in
Journal of clinical pathology
This review article summarises systems for categorisation of diagnostic errors in pathology and cytology with regard to diagnostic accuracy and the published information on human factors (HFs) in pathology to date. A 12-point event-based checklist for errors of diagnostic accuracy in histopathology and cytopathology is proposed derived from Dupont'...
Krigsfeld, Gabriel S Prince, Emily A Pratt, James Chizhevsky, Vladislav William Ragheb, Josette Novotny, James Jr Huron, David
Published in
Journal of clinical pathology
Programmed death-1/programmed death ligand 1 (PD-1/PD-L1) inhibitor therapy is accompanied by companion or complementary PD-L1 testing in some tumour types. We investigated utilisation of the Dako PD-L1 IHC 28-8 and 22C3 pharmDx assays and the Ventana PD-L1 (SP142) assay and evaluated concordance between the 28-8 and 22C3 assays in a real-world coh...
Sun, Qisi Atzmony, Lihi Zaki, Theodore Peng, Albert Sugarman, Jeffrey Choate, Keith A
Published in
Journal of clinical pathology
Basal cell carcinoma (BCC) is the most common human malignant neoplasm. However, there are multiple BCC subtypes that share clinical features while demanding different management. We present a case of a woman with hundreds of BCCs throughout her body that were resistant to vismodegib and without other features of basal cell nevus syndrome. Histolog...
Molina, Angel Alférez, Santiago Boldú, Laura Acevedo, Andrea Rodellar, José Merino, Anna
Published in
Journal of clinical pathology
Morphological recognition of red blood cells infected with malaria parasites is an important task in the laboratory practice. Nowadays, there is a lack of specific automated systems able to differentiate malaria with respect to other red blood cell inclusions. This study aims to develop a machine learning approach able to discriminate parasitised e...
Brierley, Daniel J Farthing, Paula M Zijlstra-Shaw, Sandra
Published in
Journal of clinical pathology
A Delphi study to triangulate and determine the relative importance of the key qualities of trainees identified from qualitative interviews that sought to understand how consultant histopathologists determine diagnostic competences in trainees. Twelve participants were purposively chosen for the Delphi to form an expert panel of relevant stakeholde...
Marin, Irina Ofek, Efrat Bar, Jair Prisant, Nadia Perelman, Marina Avivi, Camila Lavy-Shahaf, Gitit Onn, Amir Katz, Ruth Barshack, Iris
...
Published in
Journal of clinical pathology
To analyse microRNA (miR)-21 distribution and expression at the cellular level in non-small cell lung cancer (NSCLC). MiR-21 is an oncogenic microRNA overexpressed in NSCLC. In previous studies, overexpression of miR-21 was evaluated from the tumour bulk by quantitative reverse transcription PCR with results expressed on average across the entire c...
Dumas, Cécile Tirard-Collet, Pauline Mestrallet, Fanélie Girard, Sandrine Jallades, Laurent Picot, Stéphane Bienvenu, Anne-Lise
Published in
Journal of clinical pathology
The aim was to assess the flagging performance of Sysmex XN-10 haematology analyser for malaria detection through the parasitic red blood cell ('pRBC') alarm. We retrospectively studied 584 blood samples performed on the Sysmex XN-10 analyser that were tested for malaria. Sensitivity, specificity, positive and negative predictive values, and preval...
Arnold, Lyle Alexiadis, Vassilios Watanaskul, Tim Zarrabi, Vahid Poole, Jason Singh, Veena
Published in
Journal of clinical pathology
The identification of actionable DNA mutations associated with a patient's tumour is critical for devising a targeted, personalised cancer treatment strategy. However, these molecular analyses are typically performed using tissue obtained via biopsy, which involves substantial risk and is often not feasible. In addition, biopsied tissue does not al...
Nowak, Klaudia DiPalma, Adam Serra, Stefano Quereshy, Fayez Jackson, Timothy Okrainec, Allan Chetty, Runjan
Published in
Journal of clinical pathology
Bariatric surgical procedures are employed when there is a failure of lifestyle modification in arresting obesity. Laparoscopic sleeve gastrectomy (LSG) is quickly becoming the bariatric surgical procedure of choice. LSG results in a gastric remnant that is subject to pathological examination. The objective of this paper is to review the literature...
Fujikura, Kohei Yoshida, Makoto Uesaka, Kazuma
Published in
Journal of clinical pathology
Intravascular NK/T-cell lymphoma (IVNKTCL) is a rare disease, which is characterised by exclusive growth of large cells within the lumen of small vessels, Epstein-Barr virus infection and somatic mutations in epigenetic regulator genes. Here, we elucidate the transcriptomic complexity of IVNKTCL. IVNKTCL cases were retrieved from a single-centre co...
