Dagher, Julien Brunot, Angelique Evrard, Bertrand Kammerer-Jacquet, Solene-Florence Beaumont, Marion Cornevin, Laurence Derquin, Fanny Verhoest, Gregory Bensalah, Karim Lespagnol, Alexandra
...
Published in
Journal of clinical pathology
The dynamics of metastatic evolution in clear cell renal cell carcinoma (ccRCC) are complex. We report a case study where tumour heterogeneity resulting from clonal evolution is a frequent feature and could play a role in metastatic dissemination.We used an integrative multiomics strategy combining genomic and transcriptomic data to classify fourte...
Griffin, Jon Chen, Yuqing Catto, James W F El-Khamisy, Sherif
Published in
Journal of clinical pathology
NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational event...
Henry, Brandon Michael Cheruiyot, Isaac Benoit, Stefanie W Sanchis-Gomar, Fabian Lippi, Giuseppe Benoit, Justin
Published in
Journal of clinical pathology
The mechanism by which SARS-CoV-2 triggers cell damage and necrosis are yet to be fully elucidated. We sought to quantify epithelial cell death in patients with COVID-19, with an estimation of relative contributions of apoptosis and necrosis. Blood samples were collected prospectively from adult patients presenting to the emergency department. Circ...
Yamada, Yuichi Kohashi, Kenichi Kinoshita, Izumi Yamamoto, Hidetaka Iwasaki, Takeshi Yoshimoto, Masato Ishihara, Shin Toda, Yu Ito, Yoshihiro Kuma, Yuki
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Published in
Journal of clinical pathology
Dedifferentiation is a histological phenomenon characterised by abrupt transition of histology to a sarcomatous component with high-grade malignant potential in solitary fibrous tumour (SFT). The authors histologically reviewed SFT cases to reveal the histological background of dedifferentiated SFTs. Clinicopathological and histopathological findin...
Ibrahim, Asmaa Lashen, Ayat Toss, Michael Mihai, Raluca Rakha, Emad
Published in
Journal of clinical pathology
The assessment of cell proliferation is a key morphological feature for diagnosing various pathological lesions and predicting their clinical behaviour. Visual assessment of mitotic figures in routine histological sections remains the gold-standard method to evaluate the proliferative activity and grading of cancer. Despite the apparent simplicity ...
Malapelle, Umberto Pepe, Francesco Pisapia, Pasquale Sgariglia, Roberta Nacchio, Mariantonia Barberis, Massimo Bilh, Michel Bubendorf, Lukas Büttner, Reinhard Cabibi, Daniela
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Published in
Journal of clinical pathology
Next generation sequencing (NGS) represents a key diagnostic tool to identify clinically relevant gene alterations for treatment-decision making in cancer care. However, the complex manual workflow required for NGS has limited its implementation in routine clinical practice. In this worldwide study, we validated the clinical performance of the Targ...
Batra, Ullas Nathany, Shrinidhi Sharma, Mansi Pasricha, Sunil Bansal, Abhishek Jain, Parveen Mehta, Anurag
Published in
Journal of clinical pathology
Anaplastic lymphoma kinase (ALK) rearranged non-small cell lung carcinoma (NSCLC) is a distinct molecular subtype and rapid approval of ALK tyrosine kinase inhibitors (TKIs) has necessitated rapid and sensitive diagnostic modalities for the detection of this alteration. Gene rearrangements can be identified using many techniques including fluoresce...
Bruehl, Frido K Doxtader, Erika E Cheng, Yu-Wei Farkas, Daniel H Farver, Carol Mukhopadhyay, Sanjay
Published in
Journal of clinical pathology
Various approaches have been reported for distinguishing separate primary lung adenocarcinomas from intrapulmonary metastases in patients with two lung nodules. The aim of this study was to determine whether histological assessment is reliable and accurate in distinguishing separate primary lung adenocarcinomas from intrapulmonary metastases using ...
Kalaria, Tejas R Sanders, Anna Ford, Clare Buch, Harit Fenn, Jonathan Samuel Ashby, Helen L Mohammed, Pervaz Gama, Rousseau Mariano
Published in
Journal of clinical pathology
Thyroid stimulating hormone (TSH) assays provided by Abbott Laboratories and Roche Diagnostics are used by approximately 75% of laboratories in the UK. We assessed the potential impact of Abbott and Roche TSH assay differences on the biochemical assessment of levothyroxine replacement in primary hypothyroidism. Samples from 100 consecutive primary ...
Fischer, Edgar G
Published in
Journal of clinical pathology
