Acute kidney injury caused by COVID-19 in a patient with Crohn's disease treated with adalimumab.
...Published in Journal of clinical pathology
Immunoinformatic approach to assess SARS-CoV-2 protein S epitopes recognised by the most frequent MHC-I alleles in the B...
Published in Journal of clinical pathology
Brazil is nowadays one of the epicentres of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and new therapies are needed to face it. In the context of specific immune response against the virus, a correlation between Major Histocompatibility Complex Class I (MHC-I) and the severity of the disease in patients with COVID-19 ...
Current and future applications of artificial intelligence in pathology: a clinical perspective.
Published in Journal of clinical pathology
During the last decade, a dramatic rise in the development and application of artificial intelligence (AI) tools for use in pathology services has occurred. This trend is often expected to continue and reshape the field of pathology in the coming years. The deployment of computational pathology and applications of AI tools can be considered as a pa...
Digital pathology and artificial intelligence will be key to supporting clinical and academic cellular pathology through...
Published in Journal of clinical pathology
The measures to control the COVID-19 outbreak will likely remain a feature of our working lives until a suitable vaccine or treatment is found. The pandemic has had a substantial impact on clinical services, including cancer pathways. Pathologists are working remotely in many circumstances to protect themselves, colleagues, family members and the d...
Clinical digital neuropathology: experience and observations from a departmental digital pathology training programme, v...
Published in Journal of clinical pathology
To train and individually validate the neuropathologists in digital primary diagnosis and frozen section reporting using a novel protocol endorsed by the Royal College of Pathologists. The protocol allows early exposure to live digital reporting in a risk mitigated environment. Two specialist neuropathologists completed training in the use of a dig...
Rocky road to digital diagnostics: implementation issues and exhilarating experiences.
Published in Journal of clinical pathology
Since 2007, we have gradually been building up infrastructure for digital pathology, starting with a whole slide scanner park to build up a digital archive to streamline doing multidisciplinary meetings, student teaching and research, culminating in a full digital diagnostic workflow where we are currently integrating artificial intelligence algori...
Establishment of a remote diagnostic histopathology service using whole slide imaging (digital pathology).
Published in Journal of clinical pathology
Whole slide imaging (WSI) has diverse applications in modern pathology practice, including providing histopathology services to remote locations. Utilising an existing contractual partnership with a Northern Ontario group of hospitals, the feasibility of using WSI for primary diagnostic services from Toronto was explored by the dedicated working gr...
Use of whole slide imaging (WSI) for distance teaching.
Published in Journal of clinical pathology
Time, travel and financial constraints have meant that traditional visiting teaching engagements are more difficult to accomplish. This has been exacerbated with the advent of the COVID-19 pandemic. The use of digital pathology and whole slide imaging (WSI) as an educational tool for distance teaching is underutilised and not fully exploited. This ...
Integration of computer-aided automated analysis algorithms in the development and validation of immunohistochemistry bi...
Published in Journal of clinical pathology
In an era when immunohistochemistry (IHC) is increasingly depended on for histological subtyping, and IHC-determined biomarker informing rapid treatment choices is on the horizon; reproducible, quantifiable techniques are required. This study aimed to compare automated IHC scoring to quantify 6 DNA damage response protein markers using a tissue mic...
Diagnostic concordance and discordance in digital pathology: a systematic review and meta-analysis.
Published in Journal of clinical pathology
Digital pathology (DP) has the potential to fundamentally change the way that histopathology is practised, by streamlining the workflow, increasing efficiency, improving diagnostic accuracy and facilitating the platform for implementation of artificial intelligence-based computer-assisted diagnostics. Although the barriers to wider adoption of DP h...
