Covidin, a possible new player between hepcidin and ferroportin in hypoxia and inflammation caused by COVID-19.
Published in Journal of cellular biochemistry
Covidin, a possible new player between hepcidin and ferroportin in hypoxia and inflammation caused by COVID-19.
Review of cancer cell resistance mechanisms to apoptosis and actual targeted therapies.
Published in Journal of cellular biochemistry
The apoptosis pathway is a programmed cell death mechanism that is crucial for cellular and tissue homeostasis and organ development. There are three major caspase-dependent pathways of apoptosis that ultimately lead to DNA fragmentation. Cancerous cells are known to highly regulate the apoptotic pathway and its role in cancer hallmark acquisition ...
Methylglyoxal induces ambience for cancer promotion in HepG2 cells via Warburg effect and promotes glycation.
Published in Journal of cellular biochemistry
Methylglyoxal (MGO) is a toxic, highly reactive metabolite derived mainly from glucose and amino acids degradation. MGO is also one of the prime precursors for advanced glycation end products formation. The present research was performed to check whether MGO has any role in the promotion of cancer in HepG2 cells. For this, cells were incubated with...
The prominence of potential biomarkers in the diagnosis and management of hepatocellular carcinoma: Current scenario and...
Published in Journal of cellular biochemistry
Hepatocellular carcinoma (HCC) is one of the most aggressive and truculent types of cancer. Early detection of HCC is a massive concern that can boost the overall survival rates of HCC patients. As a result, there is a continual quest for advancements in screening, diagnosis, and treatment strategies to enhance the prognosis at its early stages. Ho...
Endoplasmic reticulum stress in nonalcoholic (metabolic associated) fatty liver disease (NAFLD/MAFLD).
Published in Journal of cellular biochemistry
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation in the absence of excessive alcohol consumption and is strongly associated with obesity, type 2 diabetes (T2DM) and other metabolic syndrome features. NAFLD is becoming increasingly prevalent and currently constitutes the leading cause of hepatocellular carcinoma ...
Physical exercise positively modulates nonalcoholic steatohepatitis-related hepatic endoplasmic reticulum stress.
Published in Journal of cellular biochemistry
Obesity is a predictive factor for the development of nonalcoholic steatohepatitis (NASH). Although some of the mechanisms associated with NASH development are still elusive, its pathogenesis relies on a complex broad spectrum of (interconnected) metabolic-based disorders. We analyzed the effects of voluntary physical activity (VPA) and endurance t...
Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis.
Published in Journal of cellular biochemistry
Hepatic fibrosis can be considered as a deregulated wound healing process in response to chronic liver injury. Bone morphogenetic protein 13 (BMP13) has been described to promote bone and tendon repair. In this study, we aimed to analyze the expression and function of BMP13 in hepatic fibrosis. We found increased BMP13 expression during the activat...
Targeting the lysosome: Mechanisms and treatments for nonalcoholic fatty liver disease.
Published in Journal of cellular biochemistry
The multiple functions of the lysosome, including degradation, nutrient sensing, signaling, and gene regulation, enable the lysosome to regulate lipid metabolism at different levels. In this review, I summarize the recent studies on lysosomal regulation of lipid metabolism and the alterations of the lysosome functions in the livers affected by nona...
Disruption of the MICOS complex leads to an aberrant cristae structure and an unexpected, pronounced lifespan extension ...
Published in Journal of cellular biochemistry
Mitochondria are dynamic eukaryotic organelles involved in a variety of essential cellular processes including the generation of adenosine triphosphate (ATP) and reactive oxygen species as well as in the control of apoptosis and autophagy. Impairments of mitochondrial functions lead to aging and disease. Previous work with the ascomycete Podospora ...
Reduced insulin signaling and high glucagon in early insulin resistance impaired fast-fed regulation of renal gluconeoge...
Published in Journal of cellular biochemistry
Gluconeogenesis is one of the key processes through which the kidney contributes to glucose homeostasis. Urinary exosomes (uE) have been used to study renal gene regulation noninvasively in humans and rodents. Recently, we demonstrated fast-fed regulation of phosphoenolpyruvate carboxykinase (PEPCK), the rate-limiting enzyme for gluconeogenesis, in...
