Katane, Masumi Matsuda, Satsuki Saitoh, Yasuaki Miyamoto, Tetsuya Sekine, Masae Sakai-Kato, Kumiko Homma, Hiroshi
Published in
Journal of cellular biochemistry
Multiple d-amino acids are present in mammalian cells, and these compounds have distinctive physiological functions. Among the free d-amino acids identified in mammals, d-aspartate plays critical roles in the neuroendocrine and endocrine systems, as well as in the central nervous system. Mammalian cells have the molecular apparatus necessary to tak...
Pallapati, Anusha R Sirigiri, Sri D Jain, Swati Ratnala, Vamsi Roy, Ipsita
Published in
Journal of cellular biochemistry
Glycerol 3-phosphate dehydrogenase (Gpd1 isoform) catalyzes the rate limiting step of glycerol synthesis and is a critical component of the osmo-responsive machinery in yeast. The three-dimensional structure of the enzyme is similar to the enzyme from many other organisms, including humans. A recent study with the human enzyme has proposed K120 (K1...
Li, Ching-Hao Palanisamy, Kalaiselvi Li, Xin Yu, Shao-Hua Wang, I-Kuan Li, Chi-Yuan Sun, Kuo-Ting
Published in
Journal of cellular biochemistry
Bone is the common extra-hepatic site for cancer metastasis. Hepatic cancer is associated with a higher incidence of pathological fracture. However, this important regulatory mechanism remains unexplored. Thus, exosome-mediated cell-cell communication between hepatocellular cancer and bone might be key to osteolytic bone destruction. Huh-7 exosomes...
Kumar, S Udhaya Rajan, Bithia Kumar, D Thirumal Cathryn, R Hephzibah Das, Samprita 5th Zayed, Hatem Emmanuel Jebaraj Walter, Charles Ramanathan, Gnanasambandan Priya Doss C, George
Published in
Journal of cellular biochemistry
Genome-wide association studies (GWAS) have identified an association between polymorphisms in the FTO gene and obesity. The FTO: rs9939609, an intronic variant, is considered a risk allele for developing diabesity in homozygous and heterozygous forms. This study aimed to investigate the molecular structure of the available inhibitors specific to t...
Vidhya, Venkataramani Malathi Ponnuraj, Karthe
Published in
Journal of cellular biochemistry
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is the key regulatory enzyme of the purine salvage pathway present in the members of trypanosomatids. The parasite solely depends on this pathway for the synthesis of nucleotides due to the absence of the de novo pathway. This study intends to identify putative inhibitors towards Trypanosoma cr...
Chen, Tongtong Wang, Hanqi Jiang, Chaoyin Lu, Yong
Published in
Journal of cellular biochemistry
Oxidative stress is known to inhibit osteogenesis and PKD1 is implicated in bone remodeling and skeletogenesis. In the present study, we explored the role of PKD1 in osteogenesis under oxidative stress. H2 O2 was used to induce oxidative stress in rat bone marrow (BM)-mesenchymal stem cells (MSCs) during osteoblast differentiation. Alkaline phospha...
Ahamad, Shahzaib Hema, Kanipakam Kumar, Vijay Gupta, Dinesh
Published in
Journal of cellular biochemistry
Alzheimer's disease (AD) is a progressive disorder that causes brain cells to degenerate and die. AD is one of the common causes of dementia that leads to a decline in thinking, behavioral and social skills that disrupts a person's ability to function independently. Tau-tubulin kinase1 (TTBK1) is a crucial disease regulating AD protein, which is ma...
Mohanty, Abhishek Zunino, Rodolfo Soubannier, Vincent Dilipkumar, Shilpa
Published in
Journal of cellular biochemistry
Mitochondria and peroxisomes are metabolically interconnected and functionally active subcellular organelles. These two dynamic organelles, share a number of common biochemical functions such as β-oxidation of fatty acids and detoxification of peroxides. The biogenesis and morphology of both these organelles in the mammalian cells is controlled by ...
Patel, Apurva Bhatt, Mital Soni, Anjali Sharma, Preeti
Published in
Journal of cellular biochemistry
Tribulus terrestris is known to possess many pharmacological properties, most notably its anticancer activities, owing to its rich steroidal saponin contents. Even though many reports are available elucidating the anticancer potential of the herb, we, for the very first time have attempted to isolate and identified the active compound present in se...
Zhang, Hui Mao, Jun Yang, Yan-Li Liu, Chun-Tao Shen, Chen Zhang, Hong-Rui Xie, Huan-Zhang Ding, Lan
Published in
Journal of cellular biochemistry
Microtubules play crucial role in process of mitosis and cell proliferation, which have been considered as attractive drug targets for anticancer therapy. The aim of this study was to discover novel and chemically diverse tubulin inhibitors for treatment of cancer. In this investigation, the multilayer virtual screening methods, including common fe...
