da Silva, Aloma N R Pereira, Gabriel R C Bonet, Luiz Felippe Sarmento Outeiro, Tiago Fleming De Mesquita, Joelma F
Published in
Journal of cellular biochemistry
Parkinson's disease (PD) is among the most prevalent neurodegenerative disorders, affecting over 10 million people worldwide. The protein encoded by the SNCA gene, alpha-synuclein (ASYN), is the major component of Lewy body (LB) aggregates, a histopathological hallmark of PD. Mutations and posttranslational modifications (PTMs) in ASYN are known to...
Feng, Yiyuan Xu, Zhongyun Jin, Hongfu Chen, Yuanyuan Fu, Chenglai Zhang, Yu Yin, Yafu Wang, Hui Cheng, Weiwei
Published in
Journal of cellular biochemistry
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are devastating neurodegenerative diseases with no effective cure. GGGGCC repeat expansion in C9orf72 is the most common genetic cause of both ALS and FTD. A key pathological feature of C9orf72 related ALS/FTD is the presence of abnormal dipeptide repeat proteins translated from ...
Rivera, Caroline N Smith, Carly E Draper, Lillian V Kee, Madison E Cook, Norah E McGovern, Macey R Watne, Rachel M Wommack, Andrew J Vaughan, Roger A
Published in
Journal of cellular biochemistry
Elevated circulating branched-chain amino acids (BCAAs) have been correlated with the severity of insulin resistance, leading to recent investigations that stimulate BCAA metabolism for the potential benefit of metabolic diseases. BT2 (3,6-dichlorobenzo[b]thiophene-2-carboxylic acid), an inhibitor of branched-chain ketoacid dehydrogenase kinase, pr...
Ye, Bin Pei, Yingting Wang, Lujing Meng, Dehao Zhang, Yu Zou, Shuang Li, Henian Liu, Jinying Xie, Ziying Tian, Changhong
...
Published in
Journal of cellular biochemistry
Understanding the connection between senescence phenotypes and mitochondrial dysfunction is crucial in aging and premature aging diseases. Loss of mitochondrial function leads to a decline in T cell function, which plays a significant role in this process. However, more research is required to determine if improving mitochondrial homeostasis allevi...
Zhou, Peng Yu, Zhe-Cheng Cao, Cong Cui, Huai-Rui Ding, Mao-Chao Yang, Chao-Xian Liao, Min
Published in
Journal of cellular biochemistry
Pro-inflammatory microglia mainly rely on glycolysis to maintain cytokine production during ischemia, accompanied by an increase in inducible nitric oxide synthase (iNOS) and monocarboxylate transporter 1 (MCT1). The role of energy metabolism in the pro-inflammatory response of microglia is currently unclear. In this study, we tested the response o...
Gao, Qiuzhi Huang, Chao Liu, Ting Yang, Fumeng Chen, Zhihong Sun, Li Zhao, Yuanyuan Wang, Mei Luo, Liqi Zhou, Chenglin
...
Published in
Journal of cellular biochemistry
Despite surgical treatment combined with multidrug therapy having made some progress, chemotherapy resistance is the main cause of recurrence and death of gastric cancer (GC). Gastric cancer mesenchymal stem cells (GCMSCs) have been reported to be correlated with the limited efficacy of chemotherapy in GC, but the mechanism of GCMSCs regulating GC ...
Yujra, Veronica Quispe Silveira, Ericka Janine Dantas da Ribeiro, Daniel Araki Castilho, Rogerio Moraes Squarize, Cristiane Helena
Published in
Journal of cellular biochemistry
Wound healing can be influenced by genes that control the circadian cycle, including Per2 and BMAL1, which coordinate the functions of several organs, including the skin. The aim of the study was to evaluate the role of PER2 during experimental skin wound healing. Two groups (control and Per2-KO), consisting of 14 male mice each, were anesthetized ...
Jiao, Qiuxia Zhang, Yumeng Xie, Juan Liu, Fang Peng, Chaoming Pan, Qu
Published in
Journal of cellular biochemistry
The Goldview dyeing of the natural multiplasmid system of Lactobacillus plantarum PC518 was affected by temperature. The article want to identify the specific molecules that cause temperature sensitivity, then experiment on the universality of temperature sensitivity, and finally preliminarily analyze the influencing factors. At 5°C and 25°C, singl...
Huang, Chi-Ruei Chu, Yu-Ting Chang, Chia-Lo Yip, Hon-Kan Chen, Hong-Hwa
Published in
Journal of cellular biochemistry
The underlying mechanism of colorectal cells developing into cancer cells has been extensively investigated, yet is still not fully delineated, resulting in the treatment of advanced colorectal cancer (CRC) remains regrettably an unmet need. Zinc Finger Protein 746/Parkin-interacting substrate (ZNF746/PARIS) has previously been identified to play a...
Cui, Enhai Lv, Lu Wang, Bin Li, Liqin Lu, Huadong Hua, Feng Chen, Wenyan Chen, Na Yang, Liwei Pan, Ruolang
...
Published in
Journal of cellular biochemistry
Acute lung injury (ALI) is a severe condition that can progress to acute respiratory distress syndrome (ARDS), with a high mortality rate. Currently, no specific and compelling drug treatment plan exists. Mesenchymal stem cells (MSCs) have shown promising results in preclinical and clinical studies as a potential treatment for ALI and other lung-re...
