Sakashita, Mai Motoi, Noriko Yamamoto, Gaku Gambe, Emi Suzuki, Masanori Yoshida, Yukihiro Watanabe, Shun-Ichi Takazawa, Yutaka Aoki, Kazunori Ochiai, Atsushi
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Published in
Journal of cancer research and clinical oncology
Visualizing mitochondria in cancer cells from human pathological specimens may improve our understanding of cancer biology. However, using immunohistochemistry to evaluate mitochondria remains difficult because almost all cells contain mitochondria and the number of mitochondria per cell may have important effects on mitochondrial function. Herein,...
Li, Fan Wen, Zhili
Published in
Journal of cancer research and clinical oncology
Morbidity and mortality rates of Digestive System Cancers (DSC) continue to pose human lives and health. Nuclear factor erythroid 2-like protein 3 (NFE2L3) is aberrantly expressed in DSC. This study aimed to explore the clinical value and underlying mechanisms of NFE2L3 as a novel biomarker in DSC. We utilized data from databases and clinical gastr...
Zheng, Guangying Peng, Jiaxuan Shu, Zhenyu Jin, Hui Han, Lu Yuan, Zhongyu Qin, Xue Hou, Jie He, Xiaodong Gong, Xiangyang
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Published in
Journal of cancer research and clinical oncology
To construct a multi-region MRI radiomics model for predicting pathological complete response (pCR) in breast cancer (BCa) patients who received neoadjuvant chemotherapy (NACT) and provide a theoretical basis for the peritumoral microenvironment affecting the efficacy of NACT. A total of 133 BCa patients who received NACT, including 49 with confirm...
Li, Shan Mi, Tao Jin, Liming Liu, Yimeng Zhang, Zhaoxia Wang, Jinkui Wu, Xin Ren, Chunnian Wang, Zhaoying Kong, Xiangpan
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Published in
Journal of cancer research and clinical oncology
Accumulating evidence demonstrates that aberrant methylation of enhancers is crucial in gene expression profiles across several cancers. However, the latent effect of differently expressed enhancers between INSS stage 4S and 4 neuroblastoma (NB) remains elusive. We utilized the transcriptome and methylation data of stage 4S and 4 NB patients to per...
Li, Shanqi Qian, Yuzhou Xie, Wanchen Li, Xinyu Wei, Jiaying Wang, Long Ren, Guosheng Yin, Xuedong
Published in
Journal of cancer research and clinical oncology
Neutrophils are considered to be crucial players in the initiation and progression of cancer. However, the complex relationship between neutrophils and cancer prognosis remains elusive, mainly due to the significant plasticity and diversity exhibited by these immune cells. As part of our thorough investigation, we examined 38 Neutrophils-Related Ge...
Shijubou, Naoki Sumi, Toshiyuki Kubo, Terufumi Sasaki, Kenta Tsukahara, Tomohide Kanaseki, Takayuki Murata, Kenji Keira, Yoshiko Terai, Kotomi Ikeda, Tatsuru
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Published in
Journal of cancer research and clinical oncology
Although immune checkpoint inhibitors (ICIs), together with cytotoxic chemotherapy (chemoimmunotherapy), have been adapted for the initial treatment of extensive-disease small-cell lung cancer (ED-SCLC), they have achieved limited success. In ED-SCLC, a subtype of SCLC, the expression of immune-related molecules and clinical data are not well under...
Ju, Weiwei Lin, Lijuan Zhang, Qifang Lv, Xiumei Teng, Shaohui Hong, Yu Shao, Zhixiang Na, Hanyun Yu, Shengjin
Published in
Journal of cancer research and clinical oncology
This study aims to explore the role of GATA6 in lung cancer, with a focus on its impact on metabolic processes. We assessed GATA6 expression in lung cancer tissues and its association with patient prognosis. In vitro cell function experiments were conducted to investigate the effects of altered GATA6 levels on lung cancer cell proliferation and mig...
Ren, Li-Kun Lu, Ri-Shang Fei, Xiao-Bin Chen, Shao-Jie Liu, Peng Zhu, Chang-Hao Wang, Xing Pan, Yao-Zhen
Published in
Journal of cancer research and clinical oncology
Pancreatic cancer (PC) is a highly malignant tumor that poses a severe threat to human health. Brain glycogen phosphorylase (PYGB) breaks down glycogen and provides an energy source for tumor cells. Although PYGB has been reported in several tumors, its role in PC remains unclear. We constructed a risk diagnostic model of PC-related genes by WGCNA ...
Murphy, Jacob Resch, Erin E Leland, Christopher Meyer, Christian F Llosa, Nicolas J Gross, John M Pratilas, Christine A
Published in
Journal of cancer research and clinical oncology
CIC-rearranged sarcomas represent a type of undifferentiated small round cell sarcoma (USRCS) characterized by poor survival, rapid development of chemotherapy resistance, and high rates of metastasis. We aim to contribute to the growing body of knowledge regarding diagnosis, treatment, clinical course, and outcomes for these patients. This case se...
Zhao, Fang Li, Chaofan Wang, Weiwei Zhang, Yu Yao, Peizhuo Wei, Xinyu Jia, Yiwei Dang, Shaonong Zhang, Shuqun
Published in
Journal of cancer research and clinical oncology
In this study, we investigated the effects of endocrine therapy and related drugs on the body composition and bone metabolism of patients with breast cancer. Additionally, using body composition-related indicators in machine learning algorithms, the risks of osteoporosis in patients with breast cancer and healthy women were predicted. We enrolled p...
