Hunt, Heather B Pearl, Jared C Diaz, David R King, Karen B Donnelly, Eve
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Type 2 diabetes mellitus (T2DM) increases fracture risk for a given bone mineral density (BMD), which suggests that T2DM changes bone tissue properties independently of bone mass. In this study, we assessed the effects of hyperglycemia on bone tissue compositional properties, enzymatic collagen crosslinks, and advanced glycation end-products (AGEs)...
Chen, Wei Zhu, Guochun Jules, Joel Nguyen, Diep Li, Yi-Ping
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
CCAAT/enhancer-binding protein α (C/ebpα) is critical for osteoclastogenesis by regulating osteoclast (OC) lineage commitment and is also important for OC differentiation and function in vitro. However, the role of C/ebpα in postnatal skeletal development has not been reported owing to lethality in C/ebpα-/- mice from hypoglycemia within 8 hours af...
Marx, Stephen J
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Introduction Familial hypocalciuric hypercalcemia (FHH) causes lifelong hypercalcemia with features that overlap with typical primary hyperparathyroidism (PHPT). The incompleteness of this overlap has led to divergent nomenclatures for FHH. I compare two nomenclatures. One sets FHH as an entity distinct from PHPT. The other groups FHH with PHPT but...
Rozental, Tamara D Walley, Kempland C Demissie, Serkalem Caksa, Signe Martinez-Betancourt, Adriana Parker, Amber M Tsai, Joy N Yu, Elaine W Bouxsein, Mary L
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
We tested whether cortical bone tissue properties assessed by in vivo impact microindentation would distinguish postmenopausal women with recent distal radius (DRF) or hip fracture (HF) from non-fracture controls (CONT). We enrolled postmenopausal women with recent DRF (n=57), HF (n=41) or CONT (n=93), and used impact microindentation to assess bon...
Tella, Sri Harsha Amalou, Hayet Wood, Bradford J Chang, Richard Chen, Clara C Robinson, Cemre Millwood, Michelle Guthrie, Lori C Xu, Sheng Levy, Elliot
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Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Tumor-induced osteomalacia (TIO) is a debilitating paraneoplastic condition caused by small phosphaturic mesenchymal tumors (PMTs) that secrete large amounts of the phosphate-regulating and vitamin D-regulating hormone, FGF23. Tumor removal results in cure. However, because of high perioperative comorbidity, either from tumor location or host facto...
Stokes, Victoria J Nielsen, Morten F Hannan, Fadil M Thakker, Rajesh V
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Hypercalcemia is defined as a serum calcium concentration that is greater than two standard deviations above the normal mean, which in children may vary with age and sex, reflecting changes in the normal physiology at each developmental stage. Hypercalcemic disorders in children may present with hypotonia, poor feeding, vomiting, constipation, abdo...
Rivadeneira, Fernando Uitterlinden, Andre G
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Karasik, David Demissie, Serkalem Lu, Darlene Broe, Kerry E Boyd, Steven K Liu, Ching-Ti Hsu, Yi-Hsiang Bouxsein, Mary L Kiel, Douglas P
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Genetic factors contribute to the risk of bone fractures, partly because of effects on bone strength. High-resolution peripheral quantitative computed tomography (HR-pQCT) estimates bone strength using micro-finite element analysis (µFEA). The goal of this study was to investigate if the bone failure load estimated by HR-pQCT-based µFEA is heritabl...
Vadiveloo, Thenmalar Donnan, Peter T Leese, Graham P
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
There are very few reports on the epidemiology of chronic hypoparathyroidism. A population-based study was undertaken to describe the prevalence and incidence of hypoparathyroidism in Tayside, Scotland. Data on biochemistry, hospital admissions, prescribing, and death records in Tayside, Scotland, from 1988 to 2015 were linked electronically. Patie...
Underbjerg, L Malmstroem, S Sikjaer, T Rejnmark, L
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Non-surgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP) are both rare diseases, characterized by hypocalcemia. In Ns-HypoPT, PTH levels are low, whereas patients with PHP often have very high levels due to receptor-insensitivity to PTH (PTH-resistance). Accordingly, we hypothesized that indices of bone turnover and bone miner...
