Lu, Tianyuan Forgetta, Vincenzo Zhou, Sirui Richards, J Brent Greenwood, Celia Mt
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores for bone mineral density have demonstrated potential clinical utility. However, the value of rare genetic determinants in risk prediction has not been assessed. With whole-exome sequencing data from 436,824 UK Biobank participants, we assigned White British anc...
Dubois, Vanessa Ciancia, Silvia Doms, Stefanie El Kharraz, Sarah Sommers, Vera Kim, Na Ri David, Karel Van Dijck, Jolien Valle-Tenney, Roger Maes, Christa
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Transgender youth increasingly present at pediatric gender services. Some of them receive long-term puberty suppression with gonadotropin-releasing hormone analogues (GnRHa) before starting gender-affirming hormones (GAH). The impact of GnRHa use started in early puberty on bone composition and bone mass accrual is unexplored. It is furthermore unc...
Leslie, William D Binkley, Neil Schousboe, John T McCloskey, Eugene V Johansson, Helena Harvey, Nicholas C Kanis, John A
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
FRAX, which is used to assess fracture probability, considers body mass index (BMI), but BMI may not reflect individual variation in body composition and distribution. We examined the effect of BMI-discordant abdominal thickness on FRAX-derived fracture probability for major osteoporotic fracture (MOF) and hip fracture. We studied 73,105 individual...
Sing, Chor-Wing Lin, Tzu-Chieh Bartholomew, Sharon Bell, J Simon Bennett, Corina Beyene, Kebede Bosco-Levy, Pauline Bradbury, Brian D Chan, Amy Hai Yan Chandran, Manju
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
In this international study, we examined the incidence of hip fractures, postfracture treatment, and all-cause mortality following hip fractures, based on demographics, geography, and calendar year. We used patient-level healthcare data from 19 countries and regions to identify patients aged 50 years and older hospitalized with a hip fracture from ...
Jaiswal, Raju Zoulakis, Michail Axelsson, Kristian F Darelid, Anna Rudäng, Robert Sundh, Daniel Litsne, Henrik Johansson, Lisa Lorentzon, Mattias
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
No previous studies have investigated the association between the bone material strength index (BMSi; an indicator of bone material properties obtained by microindentation) and the risk of incident fracture. The primary purpose of this prospective cohort study was to evaluate if BMSi is associated with incident osteoporotic fracture in older women ...
Madanhire, Tafadzwa Goedecke, Julia H Ward, Kate A Jaff, Nicole Crowther, Nigel J Norris, Shane Ferrand, Rashida A Rehman, Andrea M Micklesfield, Lisa K Gregson, Celia L
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
An estimated 25% of South African women live with human immunodeficiency virus (HIV). Antiretroviral therapy roll-out has improved life expectancy, so many more women now reach menopause. We aimed to quantify changes in bone mineral density (BMD) during the menopausal transition in urban-dwelling South African women with and without HIV and determi...
Cao, Tingyi Zhao, Jiaxuan Hong, Xiumei Wang, Guoying Pearson, Colleen Adams, William G Hu, Frank B Wang, Xiaobin Liang, Liming
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Although the maternal intrauterine metabolic environment has been recognized to have a profound impact on fetal growth and development with lifelong health implications, to our knowledge, there have been few large-scale birth cohort studies linking the cord metabolome (reflecting both the maternal and fetal metabolic state) with postnatal height me...
Kim, Min Lin, Tzu-Chieh Arora, Tarun Zhao, Hong Balasubramanian, Akhila Stad, Robert Kees O'Kelly, James Spangler, Leslie Bradbury, Brian D Curtis, Jeffrey R
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
It is often difficult to obtain valid estimates of comparative treatment effectiveness and safety owing to differences across patient populations taking different medications in the real world. One approach for assessing comparability between treatment groups in effectiveness studies is to use negative control outcomes (NCOs). NCOs share similar so...
Talevski, Jason Daly, Robin M
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Sautchuk, Rubens Jr Yu, Chen McArthur, Matthew Massie, Christine Brookes, Paul S Porter, George A Jr Awad, Hani Eliseev, Roman A
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
The mitochondrial permeability transition pore (MPTP) and its positive regulator, cyclophilin D (CypD), play important pathophysiological roles in aging. In bone tissue, higher CypD expression and pore activity are found in aging; however, a causal relationship between CypD/MPTP and bone degeneration needs to be established. We previously reported ...