Zhang, Xiaoyu Xu, Hanfei Li, Gloria Hy Long, Michelle T Cheung, Ching-Lung Vasan, Ramachandran S Hsu, Yi-Hsiang Kiel, Douglas P Liu, Ching-Ti
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Osteoporosis, a disease characterized by low bone mineral density (BMD), increases the risk for fractures. Conventional risk factors alone do not completely explain measured BMD or osteoporotic fracture risk. Metabolomics may provide additional information. We aim to identify BMD-associated metabolomic markers that are predictive of fracture risk. ...
Robinson, Danielle E Ali, M Sanni Pallares, Natalia Tebé, Cristian Elhussein, Leena Abrahamsen, Bo Arden, Nigel K Ben-Shlomo, Yoav Caskey, Fergus J Cooper, Cyrus
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Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Bisphosphonates are the first-line treatment for preventing fractures in osteoporosis patients. However, their use is contraindicated or to be used with caution in chronic kidney disease (CKD) patients, primarily because of a lack of information about their safety and effectiveness. We aimed to investigate the safety of oral bisphosphonates in pati...
Zhao, Xiaoli Lin, Shuai Li, Huiying Si, Shuyi Wang, Zhen
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Myeloperoxidase (MPO) is a heme peroxidase that plays an important role in innate immunity for host defense against invading microorganisms by catalyzing hydrogen peroxide (H2O2)-mediated reactions. Although many reports indicate MPO exerts beneficial or detrimental effects on a variety of inflammatory diseases, little is known with regard to its f...
Yau, Michelle S Kuipers, Allison L Price, Ryan Nicolas, Aude Tajuddin, Salman M Handelman, Samuel K Arbeeva, Liubov Chesi, Alessandra Hsu, Yi-Hsiang Liu, Ching-Ti
...
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Genetic studies of bone mineral density (BMD) largely have been conducted in European populations. We therefore conducted a meta-analysis of six independent African ancestry cohorts to determine whether previously reported BMD loci identified in European populations were transferable to African ancestry populations. We included nearly 5000 individu...
Kiuchi, Zentaro Reyes, Monica Jüppner, Harald
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Preferential transmission of a genetic mutation to the next generation, referred to as transmission ratio distortion (TRD), is well established for several dominant disorders, but underlying mechanisms remain undefined. Recently, TRD was reported for patients affected by pseudohypoparathyroidism type Ia or pseudopseudohypoparathyroidism. To determi...
Bedel, Cihan Korkut, Mustafa
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Sugiyama, Toshihiro
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
D'Silva, Kristin M Cromer, Sara Jane Yu, Elaine W Fischer, Michael Kim, Seoyoung C
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Zoledronic acid (ZA) is an effective agent in osteoporosis and malignancy-related bone disease but may be associated with increased risk of atrial fibrillation (AF), although current studies disagree on this risk. To examine the risk of incident AF among patients receiving ZA compared with denosumab in the first year of treatment, we performed a ne...
Seefried, Lothar Dahir, Kathryn Petryk, Anna Högler, Wolfgang Linglart, Agnès Martos-Moreno, Gabriel Ángel Ozono, Keiichi Fang, Shona Rockman-Greenberg, Cheryl Kishnani, Priya S
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Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Hypophosphatasia (HPP) is a rare, inherited, metabolic disease caused by deficient tissue non-specific alkaline phosphatase activity. This study aims to assess patient-reported pain, disability and health-related quality of life (HRQoL) in a real-world cohort of adults with HPP who were not receiving asfotase alfa during the analysis. Adults (≥18 y...
Ward, Kate A
Published in
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
