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Identifying rare genetic determinants for improved polygenic risk prediction of bone mineral density and fracture risk.

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores for bone mineral density have demonstrated potential clinical utility. However, the value of rare genetic determinants in risk prediction has not been assessed. With whole-exome sequencing data from 436,824 UK Biobank participants, we assigned White British anc...

Testosterone Restores Body Composition, Bone Mass, and Bone Strength Following Early Puberty Suppression in a Mouse Mode...

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Transgender youth increasingly present at pediatric gender services. Some of them receive long-term puberty suppression with gonadotropin-releasing hormone analogues (GnRHa) before starting gender-affirming hormones (GAH). The impact of GnRHa use started in early puberty on bone composition and bone mass accrual is unexplored. It is furthermore unc...

Effect of BMI-Discordant Abdominal Tissue Thickness on Fracture Probability: A Registry-Based Study.

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

FRAX, which is used to assess fracture probability, considers body mass index (BMI), but BMI may not reflect individual variation in body composition and distribution. We examined the effect of BMI-discordant abdominal thickness on FRAX-derived fracture probability for major osteoporotic fracture (MOF) and hip fracture. We studied 73,105 individual...

Global Epidemiology of Hip Fractures: Secular Trends in Incidence Rate, Post-Fracture Treatment, and All-Cause Mortality...

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

In this international study, we examined the incidence of hip fractures, postfracture treatment, and all-cause mortality following hip fractures, based on demographics, geography, and calendar year. We used patient-level healthcare data from 19 countries and regions to identify patients aged 50 years and older hospitalized with a hip fracture from ...

Increased Bone Material Strength Index Is Positively Associated With the Risk of Incident Osteoporotic Fractures in Olde...

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

No previous studies have investigated the association between the bone material strength index (BMSi; an indicator of bone material properties obtained by microindentation) and the risk of incident fracture. The primary purpose of this prospective cohort study was to evaluate if BMSi is associated with incident osteoporotic fracture in older women ...

The Impact of Human Immunodeficiency Virus and Menopause on Bone Mineral Density: A Longitudinal Study of Urban-Dwelling...

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

An estimated 25% of South African women live with human immunodeficiency virus (HIV). Antiretroviral therapy roll-out has improved life expectancy, so many more women now reach menopause. We aimed to quantify changes in bone mineral density (BMD) during the menopausal transition in urban-dwelling South African women with and without HIV and determi...

Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence.

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Although the maternal intrauterine metabolic environment has been recognized to have a profound impact on fetal growth and development with lifelong health implications, to our knowledge, there have been few large-scale birth cohort studies linking the cord metabolome (reflecting both the maternal and fetal metabolic state) with postnatal height me...

Comparability of Osteoporosis Treatment Groups Among Female Medicare Beneficiaries in the United States.

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

It is often difficult to obtain valid estimates of comparative treatment effectiveness and safety owing to differences across patient populations taking different medications in the real world. One approach for assessing comparability between treatment groups in effectiveness studies is to use negative control outcomes (NCOs). NCOs share similar so...

Additional Insights on the Osteoporosis Care Gap.

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Role of the Mitochondrial Permeability Transition in Bone Metabolism and Aging.

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

The mitochondrial permeability transition pore (MPTP) and its positive regulator, cyclophilin D (CypD), play important pathophysiological roles in aging. In bone tissue, higher CypD expression and pore activity are found in aging; however, a causal relationship between CypD/MPTP and bone degeneration needs to be established. We previously reported ...