Kikiowo, Babatomiwa Ahmad, Iqrar Alade, Adebowale A T Ijatuyi, Taiwo Iwaloye, Opeyemi Patel, Harun M
Published in
Journal of biomolecular structure & dynamics
Diabetes mellitus (DM) is a group of metabolic disorders characterised by chronic hyperglycaemia. DM is currently one of the top ten causes of death in humans. Chronic hyperglycaemia in DM leads to long-term damage and failure of different organs in the body. Type 2 DM (T2D) is the most common DM form, characterised by peripheral insulin resistance...
Barman, Soumen Sahoo, Snehasudha Subhadarsini Padhan, Jyotirmayee Sudhamalla, Babu
Published in
Journal of biomolecular structure & dynamics
Bromodomains are evolutionarily conserved structural motifs that recognize acetylated lysine residues on histone tails. They play a crucial role in shaping chromatin architecture and regulating gene expression in various biological processes. Mutations in bromodomains containing proteins lead to multiple human diseases, which makes them attractive ...
Verma, Annu Jakhar, Ritu Kumar, Dev Kumar, Vijay Dhillon, Twinkle Dangi, Mehak Chhillar, Anil Kumar
Published in
Journal of biomolecular structure & dynamics
Medicinal plants possess therapeutic potential for reducing reactive oxygen species (ROS)-mediated cellular damage. Hydroxytyrosol is one of the most potent antioxidants that served as control in the current study, including other synthetic antioxidants to computationally identify the antioxidant properties of Silymarin. The sequences of the recept...
Alwaleedy, Suad Mohemmed, Saeed Karale, Ravi Kabara, Komal Kumbharkhane, Ashok Roy, Bunty Sarode, Arvind
Published in
Journal of biomolecular structure & dynamics
Physical, chemical and microbiological stability of the materials is affected by the rotational and translational mobility of free and hydrated water. The role of water in areas such as protein hydration and enzyme activity, food technology, lyophilization and polymers hydration is, therefore, important and can be well understood in terms of dielec...
Abhinand, Chandran S Prabhakaran, Athira A Krishnamurthy, Anand Raju, Rajesh Keshava Prasad, Thottethodi Subrahmanya Nair, Achuthsankar S Rajasekharan, Kallikat N Oommen, Oommen V Sudhakaran, Perumana R
Published in
Journal of biomolecular structure & dynamics
The outbreak of severe acute respiratory coronavirus 2 (SARS-CoV-2) has created a public health emergency globally. SARS-CoV-2 enters the human cell through the binding of the spike protein to human angiotensin converting enzyme 2 (ACE2) receptor. Significant changes have been reported in the mutational landscape of SARS-CoV-2 in the receptor bindi...
Erol, Ismail Kotil, Seyfullah Enes Ortakci, Fatih Durdagi, Serdar
Published in
Journal of biomolecular structure & dynamics
The changes in the SARS-CoV-2 genome have resulted in the emergence of new variants. Some of the variants have been classified as variants of concern (VOC). These strains have higher transmission rate and improved fitness. One of the prevalent were the Omicron variant. Unlike previous VOCs, the Omicron possesses fifteen mutations on the spike prote...
Khan, Saif Punnoose, Kurian Bishara, Nashwa Zaki Ali Ali, Rafat Khan, Shahira Ahmad, Saheem Marouf, Hussein Abdel-Aziz Mirza, Shadab Ishrat, Romana Haque, Shafiul
...
Published in
Journal of biomolecular structure & dynamics
Leprosy is one of the chronic diseases with which humanity has struggled globally for millennia. The potent anti-leprosy medications rifampicin, clofazimine and dapsone, among others, are used to treat leprosy. Nevertheless, even in regions of the world where these drugs have been successfully implemented, resistance continues to be observed. Due t...
Siddiqui, Gufran Ahmed Naeem, Aabgeena
Published in
Journal of biomolecular structure & dynamics
The cellular environment is densely crowded, confining biomacromolecules including proteins to less available space. This macromolecular confinement may affect the physiological conformation of proteins in long-term processes like ageing. Changes in physiological protein structure can lead to protein conformational disorders including neurodegenera...
Elgazzar, Elsayed Nafie, Mohamed S Abul-Nasr, Kareem T
Published in
Journal of biomolecular structure & dynamics
The structural, composition, and molecular interaction of silver integrated zinc oxide (20 wt.% Ag/ZnO) were investigated by X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX), and Fourier transforms infrared (FTIR) spectrum. The XRD analysis showed the polycrystalline of small crystallite size, whereas the EDX spectrum confirmed the p...
Temre, Mithlesh Kumar Devi, Bharti Singh, Vinay Kumar Goel, Yugal Yadav, Saveg Pandey, Shrish Kumar Kumar, Rajnish Kumar, Ajay Singh, Sukh Mahendra
Published in
Journal of biomolecular structure & dynamics
Recent experimental evidence from our and other laboratories has strongly indicated that glutor, a piperazine-2-one derivative, which is a pan-GLUT inhibitor, displays a promising antineoplastic action by hampering glucose uptake owing to its ability to inhibit GLUT1 and GLUT3, which are overexpressed in neoplastic cells. However, the molecular mec...
