Jaques, Christian Liebling, Michael
Published in
Journal of biomedical optics
Despite recent developments in microscopy, temporal aliasing can arise when imaging dynamic samples. Modern sampling frameworks, such as generalized sampling, mitigate aliasing but require measurement of temporally overlapping and potentially negative-valued inner products. Conventional cameras cannot collect these directly as they operate sequenti...
Gareau, Daniel S Browning, James Correa Da Rosa, Joel Suarez-Farinas, Mayte Lish, Samantha Zong, Amanda M Firester, Benjamin Vrattos, Charles Renert-Yuval, Yael Gamboa, Mauricio
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Published in
Journal of biomedical optics
Melanoma is a deadly cancer that physicians struggle to diagnose early because they lack the knowledge to differentiate benign from malignant lesions. Deep machine learning approaches to image analysis offer promise but lack the transparency to be widely adopted as stand-alone diagnostics. We aimed to create a transparent machine learning technolog...
Zhai, Xiaomin Vyas, Sunil Yeh, J Andrew Luo, Yuan
Published in
Journal of biomedical optics
Two-photon (2P) fluorescence imaging can provide background-free high-contrast images from the scattering tissues. However, obtaining a multiplane image is not straightforward. We present a two-photon volume holographic imaging (2P-VHI) system for multiplane imaging. Our goal was to design and implement a 2P-VHI system that can provide the high-con...
Rickard, Ashlyn G Zhuang, Meng DeRosa, Christopher A Zhang, Xiaojie Dewhirst, Mark W Fraser, Cassandra L Palmer, Gregory M
Published in
Journal of biomedical optics
Decreasing the oxygen consumption rate (OCR) of tumor cells is a powerful method for ameliorating tumor hypoxia. However, quantifying the change in OCR is challenging in complex experimental systems. We present a method for quantifying the OCR of two tumor cell lines using oxygen-sensitive dual-emissive boron nanoparticles (BNPs). We hypothesize th...
Sadeghipour, Negar Rangnekar, Aakanksha Folaron, Margaret Strawbridge, Rendall Samkoe, Kimberley Davis, Scott Tichauer, Kenneth
Published in
Journal of biomedical optics
Fluorescence guidance in cancer surgery (FGS) using molecular-targeted contrast agents is accelerating, yet the influence of individual patients' physiology on the optimal time to perform surgery post-agent-injection is not fully understood. Develop a mathematical framework and analytical expressions to estimate patient-specific time-to-maximum con...
Pal, Rahul Villarreal, Paula Yu, Xiaoying Qiu, Suimin Vargas, Gracie
Published in
Journal of biomedical optics
Early detection of epithelial cancers and precancers/neoplasia in the presence of benign lesions is challenging due to the lack of robust in vivo imaging and biopsy guidance techniques. Label-free nonlinear optical microscopy (NLOM) has shown promise for optical biopsy through the detection of cellular and extracellular signatures of neoplasia. Alt...
Martincek, Ivan Banovcin, Peter Goraus, Matej Duricek, Martin
Published in
Journal of biomedical optics
Endoscopes represent electro-optical devices that are used to visualize internal body cavities. The specialized endoscopic procedure of the upper gastrointestinal tract from the esophagus down to the duodenum is called an esophagogastroduodenoscopy. We bring our newly developed capsule endoscopy device as a promising alternative diagnostic method f...
Geng, Qiang Fu, Zhiqiang Chen, Shih-Chi
Published in
Journal of biomedical optics
High-speed 3D imaging methods have been playing crucial roles in many biological discoveries. We present a hybrid light-field imaging system and image processing algorithm that can visualize high-speed biological events. The hybrid light-field imaging system uses the selective plane optical illumination, which simultaneously records a high-resoluti...
Li, Zhe Hu, Bihe Li, Guang Fox, Sharon Jalal, Shadia Turek, John Brown, J Quincy Nolte, David
Published in
Journal of biomedical optics
Tumor heterogeneity poses a challenge for the chemotherapeutic treatment of cancer. Tissue dynamics spectroscopy captures dynamic contrast and can capture the response of living tissue to applied therapeutics, but the current analysis averages over the complicated spatial response of living biopsy samples. To develop tissue dynamics spectroscopic i...
Gonzalez, Eduardo A Bell, Muyinatu A Lediju
Published in
Journal of biomedical optics
Photoacoustic-based visual servoing is a promising technique for surgical tool tip tracking and automated visualization of photoacoustic targets during interventional procedures. However, one outstanding challenge has been the reliability of obtaining segmentations using low-energy light sources that operate within existing laser safety limits. We ...
