Bhartiya, Pradeep Jaiswal, Apurva Negi, Manorma Kaushik, Neha Ha Choi, Eun Kumar Kaushik, Nagendra
Published in
Journal of advanced research
Melanoma is a rare but highly malignant form of skin cancer. Although recent targeted and immune-based therapies have improved survival rates by 10-15%, effective melanoma treatment remains challenging. Therefore, novel, combinatorial therapy options such as non-thermal atmospheric pressure plasma (NTP) are being investigated to inhibit and prevent...
Li, Jingyang Zhang, Di Wang, Shaohui Yu, Peng Sun, Jiayi Zhang, Yi Meng, Xianli Li, Juan Xiang, Li
Published in
Journal of advanced research
Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been shown to promote apoptosis in non-small cell lung cancer cells. However, previous studies have not determined if baicalein exerts proapoptotic effects by modulating the metabolic pathways. To investigate if baicalein induces apoptosis in lung cancer cells by modulating the...
Tan, Wuping Wang, Yijun Cheng, Siyi Liu, Zhihao Xie, Mengjie Song, Lingpeng Qiu, Qinfang Wang, Xiaofei Li, Zeyan Liu, Tianyuan
...
Published in
Journal of advanced research
Obesity and imbalance in lipid homeostasis contribute greatly to heart failure with preserved ejection fraction (HFpEF), the dominant form of heart failure. Few effective therapies exist to control metabolic alterations and lipid homeostasis. We aimed to investigate the cardioprotective roles of AdipoRon, the adiponectin receptor agonist, in regula...
Zhilan, Tu Zengyu, Zhang Pengpeng, Jin Hualan, Yang Chao, Li Yan, Xi Zimin, Guo Shuangxing, Hou Weiwei, Li
Published in
Journal of advanced research
Salidroside (SAL), extracted from Rhodiola rosea, has been widely used in coronary heart disease and myocardial ischemia for decades. Previous studies have demonstrated that SAL could reduce arteriosclerosis, and thus combat ischemic brain damage. However, the in-depth function of the salidroside in Cerebral Small Vascular Disease (CSVD) has not be...
Wu, Junchao Li, Lisha Zhang, Tingrui Lu, Jiaye Tai, Zongguang Zhu, Quangang Chen, Zhongjian
Published in
Journal of advanced research
The promotion of epidermal barrier dysfunction is attributed to abnormalities in the lipid-microbiome positive feedback loop which significantly influences the imbalance of the epithelial immune microenvironment (EIME) in atopic dermatitis (AD). This imbalance encompasses impaired lamellar membrane integrity, heightened exposure to epidermal pathog...
Xiao, Yue Feng, Yingxuan Zhao, Jianxin Chen, Wei Lu, Wenwei
Published in
Journal of advanced research
Population aging has become a primary global public health issue, and the prevention of age-associated diseases and prolonging healthy life expectancies are of particular importance. Gut microbiota has emerged as a novel target in various host physiological disorders including aging. Comprehensive understanding on changes of gut microbiota during a...
Yang, Xin Sun, Jianqiang Jin, Bingyu Lu, Yuer Cheng, Jinyan Jiang, Jiaju Zhao, Qi Shuai, Jianwei
Published in
Journal of advanced research
With the escalating menace of organic compounds in environmental pollution imperiling the survival of aquatic organisms, the investigation of organic compound toxicity across diverse aquatic species assumes paramount significance for environmental protection. Understanding how different species respond to these compounds helps assess the potential ...
Zhang, Tingting Zhu, Mengmeng Ma, Jialing Liu, Zhenghong Zhang, Zhidan Chen, Meijie Zhao, Yaping Li, Huaxin Wang, Shengnan Wei, Xiaoning
...
Published in
Journal of advanced research
Vascular calcification, a devastating vascular complication accompanying atherosclerotic cardiovascular disease and chronic kidney disease, increases the incidence of adverse cardiovascular events and compromises the efficacy of vascular interventions. However, effective therapeutic drugs and treatments to delay or prevent vascular calcification ar...
Liu, Qianqian Jiang, Kexin Duan, Shipeng Zhao, Na Shen, Yanmei Zhu, Lirong Zhang, Ke-Qin Yang, Jinkui
Published in
Journal of advanced research
Arthrobotrys oligospora has been utilized as a model strain to study the interaction between fungi and nematodes owing to its ability to capture nematodes by developing specialized traps. A previous study showed that high-osmolarity glycerol (Hog1) signaling regulates the osmoregulation and nematocidal activity of A. oligospora. However, the functi...
Liu, Tiantian Chen, Xu Sun, Qianbin Li, Junjun Wang, Qiyan Wei, Peng Wang, Wei Li, Chun Wang, Yong
Published in
Journal of advanced research
Valerenic acid (VA) is a unique and biologically active component in Valeriana officinalis L., which has been reported to have a regulatory effect on the cardiovascular system. However, its therapeutic effects on pathological myocardial hypertrophy (PMH) and the underlying mechanisms are undefined. Our study aims to elucidate how VA improves PMH, a...