Higginbotham, Jennifer M O'Shea, Clodagh C
Published in
Journal of virology
SUMO is a key posttranslational modification that modulates the function, localization, and assembly of protein complexes. In the ever-escalating host-pathogen arms race, viruses have evolved strategies to subvert sumoylation. Adenovirus is a small DNA tumor virus that is a global human pathogen and key biomedical agent in basic research and therap...
Albornoz, Amelina Carletti, Tea Corazza, Gianmarco Marcello, Alessandro
Published in
Journal of Virology
This study (i) extends previous work that showed TIA-1/TIAR recruitment at sites of flavivirus replication, (ii) demonstrates that TIAR behaves like TIA-1 as an inhibitor of viral replication using an RNA interference (RNAi) approach in human cells that contradicts the previous hypothesis based on mouse embryonic fibroblast (MEF) knockouts only, (i...
Muhire, Brejnev Muhizi Golden, Michael Murrell, Ben Lefeuvre, Pierre Lett, Jean-Michel Gray, Alistair Poon, Art Y F Ngandu, Nobubelo Kwanele Semegni, Yves Tanov, Emil Pavlov
...
Published in
Journal of Virology
Single-stranded DNA (ssDNA) viruses have genomes that are potentially capable of forming complex secondary structures through Watson-Crick base pairing between their constituent nucleotides. A few of the structural elements formed by such base pairings are, in fact, known to have important functions during the replication of many ssDNA viruses. Unk...
M. Abdel-Mohsen X. Deng T. Liegler J. C. Guatelli M. S. Salama H. E.-d. A. Ghanem A. Rauch B. Ledergerber S. G. Deeks H. F. Gunthard
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Published in
Journal of Virology
DuBois, Rebecca M Freiden, Pamela Marvin, Shauna Reddivari, Muralidhar Heath, Richard J White, Stephen W Schultz-Cherry, Stacey
Published in
Journal of virology
Astroviruses are small, nonenveloped, single-stranded RNA viruses that cause diarrhea in a wide variety of mammals and birds. On the surface of the viral capsid are globular spikes that are thought to be involved in attachment to host cells. To understand the basis of species specificity, we investigated the structure of an avian astrovirus capsid ...
Alam, S Munir Liao, Hua-Xin Tomaras, Georgia D Bonsignori, Mattia Tsao, Chun-Yen Hwang, Kwan-Ki Chen, Haiyan Lloyd, Krissey E Bowman, Cindy Sutherland, Laura
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Published in
Journal of virology
An immune correlates analysis of the RV144 HIV-1 vaccine trial revealed that antibody responses to the gp120 V1/V2 region correlated inversely with infection risk. The RV144 protein immunogens (A244-rp120 and MN-rgp120) were modified by an N-terminal 11-amino-acid deletion (Δ11) and addition of a herpes simplex virus (HSV) gD protein-derived tag (g...
Furió, Victoria Garijo, Raquel Durán, María Moya, Andrés Bell, John C Sanjuán, Rafael
Published in
Journal of virology
Given the parasitic nature of viruses, it is sometimes assumed that rates of viral replication and dissemination within hosts (within-host fitness) correlate with virulence. However, there is currently little empirical evidence supporting this principle. To test this, we quantified the fitness and virulence of 21 single- or double-nucleotide mutant...
Held, Kathrin Junker, Andreas Dornmair, Klaus Meinl, Edgar Sinicina, Inga Brandt, Thomas Theil, Diethilde Derfuss, Tobias
Published in
Journal of Virology
Herpes simplex type 1 (HSV-1) is a neurotropic virus which establishes lifelong latency in human trigeminal ganglia (TG). Currently, two nonexclusive control mechanisms of HSV-1 latency are discussed: antiviral CD8(+) T cells and viral microRNAs (miRNAs) encoded by the latency associated transcript (LAT). We investigate here to what extent these me...
O'Rourke, Sara M Schweighardt, Becky Phung, Pham Fonseca, Dora P A J Terry, Karianne Wrin, Terri Sinangil, Faruk Berman, Phillip W
Published in
Journal of virology
Understanding the determinants of neutralization sensitivity and resistance is important for the development of an effective human immunodeficiency virus type 1 (HIV-1) vaccine. In these studies, we have made use of the swarm of closely related envelope protein variants (quasispecies) from an extremely neutralization-resistant clinical isolate in o...
Guardado-Calvo, Pablo Muñoz, Eva M Antonio L Llamas-Saiz Fox, Gavin C Kahn, Richard Curiel, David T Glasgow, Joel N van Raaij, Mark J
Published in
Journal of Virology
Adenovirus isolate NADC-1, a strain of porcine adenovirus type 4, has a fiber containing an N-terminal virus attachment region, shaft and head domains, and a C-terminal galectin domain connected to the head by an RGD-containing sequence. The crystal structure of the head domain is similar to previously solved adenovirus fiber head domains, but spec...
