Jammes, Yves Adjriou, Nabil Kipson, Nathalie Criado, Christine Charpin, Caroline Rebaudet, Stanislas Stavris, Chloé Guieu, Régis Fenouillet, Emmanuel Retornaz, Frédérique
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Published in
Journal of Translational Medicine
BackgroundIn myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect the membrane excitability of resting muscles.MethodsSe...
Wu, Yuantao Zhang, Hongqi Tang, Mingxing Guo, Chaofeng Deng, Ang Li, Jiong Wang, Yunjia Xiao, Lige Yang, Guanteng
Published in
Journal of Translational Medicine
BackgroundThe etiology of congenital scoliosis (CS) is complex and uncertain. Abnormal DNA methylation affects the growth and development of spinal development. In this study, we investigated the role of DNA methylation in CS.MethodsThe target region DNA methylation level in the peripheral blood of patients with CS was analyzed. Through in-depth an...
Jiang, Zhenming Zhang, Yuxi Chen, Xi Wang, Yan Wu, Pingeng Wu, Chengzhang Chen, Dong
Published in
Journal of Translational Medicine
BackgroundAs a nucleolar protein associated with ribosome biogenesis, pescadillo homolog 1 (PES1) has been reported to participate in the development of many cancers. However, its role in prostate cancer is not clearly defined. Therefore, the aim of this study is to explore the effects and the specific mechanism of PES1 in prostate cancer.MethodsA ...
Hauge, Anette Rofstad, Einar K.
Published in
Journal of Translational Medicine
Most tumors develop abnormal fibrotic regions consisting of fibroblasts, immune cells, and a dense extracellular matrix (ECM) immersed in a viscous interstitial fluid, and an abundant fibrotic tumor microenvironment (TME) is associated with poor outcome of treatment. It has been hypothesized that the treatment of cancer may be improved by intervent...
Liu, Jingyuan Liu, Yao Xiang, Pan Pu, Lin Xiong, Haofeng Li, Chuansheng Zhang, Ming Tan, Jianbo Xu, Yanli Song, Rui
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Published in
Journal of Translational Medicine
BackgroundPatients with critical illness due to infection with the 2019 coronavirus disease (COVID-19) show rapid disease progression to acute respiratory failure. The study aimed to screen the most useful predictive factor for critical illness caused by COVID-19.MethodsThe study prospectively involved 61 patients with COVID-19 infection as a deriv...
Sugase, Takahito Lam, Bao Q. Danielson, Meggie Terai, Mizue Aplin, Andrew E. Gutkind, J. Silvio Sato, Takami
Published in
Journal of Translational Medicine
BackgroundPatients with metastatic uveal melanoma (MUM) in the liver usually die within 1 year. The development of new treatments for MUM has been limited by the lack of diverse MUM cell lines and appropriate animal models. We previously reported that orthotopic xenograft mouse models established by direct injection of MUM cells into the liver were...
Orlandi, Chiara Canovari, Benedetta Bozzano, Federica Marras, Francesco Pasquini, Zeno Barchiesi, Francesco De Maria, Andrea Magnani, Mauro Casabianca, Anna
Published in
Journal of Translational Medicine
BackgroundThe persistence of HIV-1 in reservoir cells is one of the major obstacles to eradicating the virus in infected individuals receiving combination antiretroviral therapy (ART). HIV-1 persists in infected cells as a stable integrated genome and more labile unintegrated DNA (uDNA), which includes linear, 1-LTR and 2-LTR circular DNA. 2-LTR ci...
Moradian, Negar Ochs, Hans D. Sedikies, Constantine Hamblin, Michael R. Camargo, Carlos A. Jr. Martinez, J. Alfredo Biamonte, Jacob D. Abdollahi, Mohammad Torres, Pedro J. Nieto, Juan J.
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Published in
Journal of Translational Medicine
The COVID-19 pandemic has become the leading societal concern. The pandemic has shown that the public health concern is not only a medical problem, but also affects society as a whole; so, it has also become the leading scientific concern. We discuss in this treatise the importance of bringing the world’s scientists together to find effective solut...
Rogers, Christopher J. Harman, Robert J. Bunnell, Bruce A. Schreiber, Martin A. Xiang, Charlie Wang, Fu-Sheng Santidrian, Antonio F. Minev, Boris R.
Published in
Journal of Translational Medicine
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per day. Less than 100 days later, the World Health Organization declared that the rapidly spreading viral outbreak had become a global pandemic. Coronavirus disease 2019 (COVID-19)...
Wisgrill, Lukas Lamm, Christian Hell, Lena Thaler, Johannes Berger, Angelika Weiss, Rene Weber, Viktoria Rinoesl, Harald Hiesmayr, Michael J. Spittler, Andreas
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Published in
Journal of Translational Medicine
BackgroundExtracorporeal circulation during major cardiac surgery triggers a systemic inflammatory response affecting the clinical course and outcome. Recently, extracellular vesicle (EV) research has shed light onto a novel cellular communication network during inflammation. Hemoadsorption (HA) systems have shown divergent results in modulating th...
