Chiu, Ting-Fang Yu, Tung-Min Chiu, Chih-Wei Lee, Brian K. Lan, Tsuo-Hung Li, Chi-Yuan Lin, Mei-Chen Kao, Chia-Hung
Published in
Journal of Translational Medicine
BackgroundPolycystic kidney disease (PKD) is a common renal disorder affecting approximately 1 in 1000 live births. Tuberculosis (TB) is an infectious disease worldwide. This study investigated the risk of TB infection in patients with PKD.MethodsA nationwide population-based cohort study was performed using Taiwan’s National Health Insurance Resea...
Farrokhi, Mehrdad Manavi, Seyedeh Parisa Taheri, Fatemeh
Published in
Journal of Translational Medicine
Liu, Chang Yang, Zhe Li, Rong Wu, Yanju Chi, Ming Gao, Shuting Sun, Xun Meng, Xin Wang, Biao
Published in
Journal of Translational Medicine
N6-methyl-adenosine (m6A) is one of the most common internal modifications on RNA molecules present in mammalian cells. Deregulation of m6A modification has been recently implicated in many types of human diseases. Therefore, m6A modification has become a research hotspot for its potential therapeutic applications in the treatment of various diseas...
Park, Ilkyu Jung, Jaeeun Lee, Sugi Park, Kunhyang Ryu, Jea-Woon Son, Mi-Young Cho, Hyun-Soo Kim, Dae-Soo
Published in
Journal of Translational Medicine
BackgroundInflammatory bowel disease (IBD) is a chronic and idiopathic inflammatory disorder of the gastrointestinal tract and comprises ulcerative colitis (UC) and Crohn’s disease (CD). Crohn’s disease can affect any part of the gastrointestinal tract, but mainly the terminal ileum and colon. In the present study, we aimed to characterize terminal...
Pan, Boju Kang, Yuxin Jin, Yan Yang, Lin Zheng, Yushuang Cui, Lei Sun, Jian Feng, Jun Li, Yuan Guo, Lingchuan
...
Published in
Journal of Translational Medicine
IntroductionProgrammed cell death ligand-1 (PD-L1) expression is a promising biomarker for identifying treatment related to non-small cell lung cancer (NSCLC). Automated image analysis served as an aided PD-L1 scoring tool for pathologists to reduce inter- and intrareader variability. We developed a novel automated tumor proportion scoring (TPS) al...
Kim, So-Young Cho, Eun A. Bae, Sang Mun Kim, Sang-Yeob Park, Do Hyun
Published in
Journal of Translational Medicine
Hartl, Dominik de Luca, Valeria Kostikova, Anna Laramie, Jason Kennedy, Scott Ferrero, Enrico Siegel, Richard Fink, Martin Ahmed, Sohail Millholland, John
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Published in
Journal of Translational Medicine
In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of how drugs are discovered, developed and marketed. Critical to this transformation is the adoption of new tec...
Rachiglio, Anna Maria De Sabato, Luca Roma, Cristin Cennamo, Michele Fiorenza, Mariano Terracciano, Daniela Pasquale, Raffaella Bergantino, Francesca Cavalcanti, Ernesta Botti, Gerardo
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Published in
Journal of Translational Medicine
BackgroundSince the first complete genome sequencing of SARS-CoV-2 in December 2019, more than 550,000 genomes have been submitted into the GISAID database. Sequencing of the SARS-CoV-2 genome might allow identification of variants with increased contagiousness, different clinical patterns and/or different response to vaccines. A highly automated n...
Li, Meina Lian, Bin Xu, Xiaoxiong Zhao, Pan Tang, Bihan Hu, Chaoqun Liu, Xiang Yu, Wenya Zhang, Lulu
Published in
Journal of Translational Medicine
BackgroundThis study aimed to explore the collaborative relationship in translational medical research from the perspective of clinicians in China. The findings are expected to help practitioners optimize and experience the greatest advantages of collaboration.MethodsWe conducted a national internet-based survey from July 29 to October 12, 2020. Of...
Steffen, Julius Schlichtiger, Jenny Brunner, Stefan Huber, Bruno C.
Published in
Journal of Translational Medicine
To investigate the COVID-19 pandemic related alteration of health promoting behaviour during lockdown among medical students compared to other students. In this cross-sectional study, we enrolled 1940 Bavarian students. Participants were asked to complete an online questionnaire 3 weeks after lockdown implementation, evaluating their lifestyle beha...
