Mané, Camille Delmas, Clément Porterie, Jean Jourdan, Géraldine Verwaerde, Patrick Marcheix, Bertrand Concordet, Didier Georges, Bernard Ruiz, Stéphanie Gandia, Peggy
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Published in
Journal of Translational Medicine
BackgroundExtracorporeal membrane oxygenation (ECMO) is increasingly used in intensive care units and can modify drug pharmacokinetics and lead to under-exposure associated with treatment failure. Ceftolozane/tazobactam is an antibiotic combination used for complicated infections in critically ill patients. Launched in 2015, sparse data are availab...
Jammes, Yves Adjriou, Nabil Kipson, Nathalie Criado, Christine Charpin, Caroline Rebaudet, Stanislas Stavris, Chloé Guieu, Régis Fenouillet, Emmanuel Retornaz, Frédérique
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Published in
Journal of Translational Medicine
BackgroundIn myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect the membrane excitability of resting muscles.MethodsSe...
Eldin, Patrick Péron, Sophie Galashevskaya, Anastasia Denis-Lagache, Nicolas Cogné, Michel Slupphaug, Geir Briant, Laurence
Published in
Journal of Translational Medicine
BackgroundHIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cellular E3 ubiquitin ligases (such as DCAF1-Cul4A E3 ligase complex) to target many host proteins and interfere with their functions....
Sweetman, Eiren Kleffmann, Torsten Edgar, Christina de Lange, Michel Vallings, Rosamund Tate, Warren
Published in
Journal of Translational Medicine
Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious and complex physical illness that affects all body systems with a multiplicity of symptoms, but key hallmarks of the disease are pervasive fatigue and ‘post-exertional malaise’, exacerbation after physical and/or mental activity of the intrinsic fatigue and other sy...
Caccuri, Francesca Zani, Alberto Messali, Serena Giovanetti, Marta Bugatti, Antonella Campisi, Giovanni Filippini, Federica Scaltriti, Erika Ciccozzi, Massimo Fiorentini, Simona
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Published in
Journal of Translational Medicine
Background Since the first outbreak of SARS-CoV-2, the clinical characteristics of the Coronavirus Disease 2019 (COVID-19) have been progressively changed. Data reporting a viral intra-host and inter-host evolution favouring the appearance of mild SARS-CoV-2 strains are since being accumulating. To better understand the evolution of SARS-CoV-2 path...
Canham, Maurice A. Campbell, John D. M. Mountford, Joanne C.
Published in
Journal of Translational Medicine
More than seven months into the coronavirus disease -19 (COVID-19) pandemic, infection from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 21.2 million cases and resulted in over 760,000 deaths worldwide so far. As a result, COVID-19 has changed all our lives as we battle to curtail the spread of the infection in t...
Feng, Zengyu Shi, Minmin Li, Kexian Ma, Yang Jiang, Lingxi Chen, Hao Peng, Chenghong
Published in
Journal of Translational Medicine
Background Cancer stem cells (CSCs) are crucial to the malignant behaviour and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). In recent years, CSC biology has been widely studied, but practical prognostic signatures based on CSC-related genes have not been established or reported in PDAC. Methods A signature was developed and validated ...
Salajegheh Tazerji, Sina Magalhães Duarte, Phelipe Rahimi, Parastoo Shahabinejad, Fatemeh Dhakal, Santosh Singh Malik, Yashpal Shehata, Awad A. Lama, Juan Klein, Jörn Safdar, Muhammad
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Published in
Journal of Translational Medicine
COVID-19 caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan (Hubei province, China) during late 2019. It has spread across the globe affecting nearly 21 million people with a toll of 0.75 million deaths and restricting the movement of most of the world population during the past 6 months. COVID-19 bec...
Liu, Lidong Zhang, Zhiwei Zhang, Guoxiang Wang, Ting Ma, Yingchun Guo, Wei
Published in
Journal of Translational Medicine
Background Epithelial ovarian cancer (EOC) is the most lethal disease among female genital malignant tumors. Peptidylarginine deiminase type II(PADI II) has been shown to enhance a variety of cancers carcinogenesis, including ovarian cancer. The purpose of this study was to investigate the biological role of PADI2 in ovarian cancer (OC) and the rel...
Lamo-Espinosa, José María Blanco, Juan F. Sánchez, Mikel Moreno, Victoria Granero-Moltó, Froilán Sánchez-Guijo, Fermín Crespo-Cullel, Íñigo Mora, Gonzalo San Vicente, Diego Delgado Pompei-Fernández, Orlando
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Published in
Journal of Translational Medicine
Background Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants must be determined. Here, we evaluated the clinical effects of a dose of 100 × 106 bone marrow mesenchymal stromal cells (BM-MSCs) ...
