High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis
International audience
Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stre...
...Published in Journal of Translational Medicine
BackgroundIt has been established that children with Autism Spectrum Disorders (ASD) are affected by oxidative stress, the origin of which is still under investigation. In the present work, we evaluated inflammatory and pro-oxidant soluble signature in non-syndromic ASD and age-matched typically developing (TD) control children.MethodsWe analyzed l...
Tissue diagnosis during colorectal cancer surgery using optical sensing: an in vivo study
...Published in Journal of Translational Medicine
BackgroundIn colorectal cancer surgery there is a delicate balance between complete removal of the tumor and sparing as much healthy tissue as possible. Especially in rectal cancer, intraoperative tissue recognition could be of great benefit in preventing positive resection margins and sparing as much healthy tissue as possible. To better guide the...
90-gene signature assay for tissue origin diagnosis of brain metastases
...Published in Journal of Translational Medicine
BackgroundBrain metastases (BM) are the most common intracranial tumors. 2–14% of BM patients present with unknown primary site despite intensive evaluations. This study aims to evaluate the performance of a 90-gene expression signature in determining the primary sites for BM samples.MethodsThe sequence-based gene expression profiles of 708 primary...
CircRNA expression profiles in human dental pulp stromal cells undergoing oxidative stress
Published in Journal of Translational Medicine
BackgroundOxidative stress has a determinantal effect on human dental pulp stromal cells (hDPSCs), including affecting their longevity and functionality. Circular RNAs (circRNAs) play an essential role in stromal cell behavior; however, the exact mechanism in which circRNAs functions within hDPSCs were undergoing oxidative stress remains unclear. T...
Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory ...
...Published in Journal of Translational Medicine
BackgroundLiquid biopsy based on cell-free DNA circulating in plasma has shown solid results as a non-invasive biomarker. In the present study we evaluated the utility of circulating free DNA (cfDNA) and the sub-type tumor DNA (ctDNA) in hepatocellular cancer (HCC) patients to assess therapy response and clinical outcome.MethodsA cohort of 13 patie...
Predictive model for acute respiratory distress syndrome events in ICU patients in China using machine learning algorith...
...Published in Journal of Translational Medicine
BackgroundTo develop a machine learning model for predicting acute respiratory distress syndrome (ARDS) events through commonly available parameters, including baseline characteristics and clinical and laboratory parameters.MethodsA secondary analysis of a multi-centre prospective observational cohort study from five hospitals in Beijing, China, wa...
Pathogenicity of new BEST1 variants identified in Italian patients with best vitelliform macular dystrophy assessed by c...
...Published in Journal of Translational Medicine
BackgroundBest vitelliform macular dystrophy (BVMD) is an autosomal dominant macular degeneration. The typical central yellowish yolk-like lesion usually appears in childhood and gradually worsens. Most cases are caused by variants in the BEST1 gene which encodes bestrophin-1, an integral membrane protein found primarily in the retinal pigment epit...
Serial plasma DNA levels as predictors of outcome in patients with acute traumatic cervical spinal cord injury
Published in Journal of Translational Medicine
BackgroundAcute traumatic cervical spinal cord injury (SCI) is a leading cause of disability in adolescents and young adults worldwide. Evidence from previous studies suggests that circulating cell-free DNA is associated with severity following acute injury. The present study determined whether plasma DNA levels in acute cervical SCI are predictive...
Milk-derived exosomes (MDEs) have a different biological effect on normal fetal colon epithelial cells compared to colon...
Published in Journal of Translational Medicine
BackgroundBreastfeeding is the ideal source of infant nutrition. Human milk consists not only of nutrients but also biologically active components. Among these latter compounds, exosomes contain proteins, lipids, mRNAs and miRNAs.MethodsTo elucidate the biological effects of milk-derived exosomes (MDEs) on normal colonic epithelial cells compared t...
