Gao, Yingzhen Shen, Liuyi Dong, Tianyue Yang, Xin Cui, Heyang Guo, Yanlin Ma, Yanchun Kong, Pengzhou Cheng, Xiaolong Zhang, Ling
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Published in
Journal of Translational Medicine
Background Aberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in eukaryotes. Although N-glycoproteomics has made contributions to the discovery of biomarkers in a variety of cancers, less is known about the abnormal glycosylation signatures in esophageal squamous cell car...
Pan, Yuliang Zhu, Yuxing Zhang, Jun Jin, Long Cao, Peiguo
Published in
Journal of Translational Medicine
Background Colorectal cancer (CRC) is a common malignant tumor with a high risk of metastasis. Long non-coding RNAs (lncRNAs) have been reported to be implicated in cancer progression via regulating its nearby gene. Herein, we investigated the function of GATA binding protein 2 (GATA2) and lncRNA GATA2 antisense RNA 1 (GATA2-AS1) in CRC and the mec...
Bei, Roberto Benvenuto, Monica Focaccetti, Chiara Fazi, Sara Moretti, Marta Nardozi, Daniela Angiolini, Valentina Ciuffa, Sara Cifaldi, Loredana Carrano, Raffaele
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Published in
Journal of Translational Medicine
Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM. Thus, molecules involved in these signaling pathways could be used for targeted therapy approaches. The aim of this study was to evaluate the effects of inhibitors of H...
Bouchard-Mercier, Annie de Toro-Martín, Juan Nadeau, Mélanie Lescelleur, Odette Lebel, Stéfane Richard, Denis Biertho, Laurent Tchernof, André Vohl, Marie-Claude
Published in
Journal of Translational Medicine
Background Bariatric surgery is an effective therapy for individuals with severe obesity to achieve sustainable weight loss and to reduce comorbidities. Examining the molecular signature of subcutaneous adipose tissue (SAT) following different types of bariatric surgery may help in gaining further insight into their distinct metabolic impact. Resul...
Jin, Guohua Zhang, Jianguang Cao, Tingting Chen, Bang Tian, Yu Shi, Yang
Published in
Journal of Translational Medicine
Background Gastric cancer (GC), as one of the most common malignancies across the globe, is the fourth leading cause of cancer-related deaths. Though a large body of research has been conducted to develop the therapeutic methods of GC, the survival rate of advanced patients is still poor. We aimed to dig into the potential regulatory mechanism of G...
Mayne, G. C. Woods, C. M. Dharmawardana, N. Wang, T. Krishnan, S. Hodge, J. C. Foreman, A. Boase, S. Carney, A. S. Sigston, E. A. W.
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Published in
Journal of Translational Medicine
Zhang, Chunlong Zhao, Jiaxin Mi, Wanqi Zhang, Yuxi Zhong, Xiaoling Tan, Guiyuan Li, Feng Li, Xia Xu, Yanjun Zhang, Yunpeng
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Published in
Journal of Translational Medicine
Glioma is the most common malignant tumors in the brain. Previous studies have revealed that, as the innate immune cells in nervous system, microglia cells were involved in glioma pathology. And, the resident microglia displayed its specific biological roles which distinguished with peripheral macrophages. In this study, an integrated analysis was ...
Jia, Yu He, Tiantian Wu, Di Tong, Jiabing Zhu, Jie Li, Zegeng Dong, Jingcheng
Published in
Journal of Translational Medicine
Background Chronic obstructive pulmonary disease (COPD), a prevalent, progressive respiratory disease, has become the third leading cause of death globally. Increasing evidence suggests that intestinal and pulmonary microbiota dysbiosis is associated with COPD. Researchers have shown that T helper (Th) 17/regulatory T (Treg) imbalance is involved i...
Lin, Hao Chen, Xiaonan Pan, Jianan Ke, Jiahan Zhang, Alian Liu, Yangyang Wang, Changqian Chang, Alex Chia Yu Gu, Jun
Published in
Journal of Translational Medicine
Background Adipose tissue homeostasis is at the heart of many metabolic syndromes such as diabetes. Previously it has been demonstrated that adipose tissues from diabetic patients are senescent but whether this contributes to diabetic cardiomyopathy (DCM) remains to be elucidated. Methods The streptozotocin (STZ) type 1 diabetic mice were establish...
Lin, Hongbing Chen, Huishan Zhao, Xuetao Ding, Tong Wang, Yawei Chen, Zhen Tian, Yue Zhang, Peipei Shen, Yuqin
Published in
Journal of Translational Medicine
Periodontitis is an inflammatory disease initiated by dysbiosis of the local microbial community. Periodontitis can result in destruction of tooth-supporting tissue; however, overactivation of the host immune response is the main reason for alveolar bone loss. Periodontal tissue cells, immune cells, and even further activated osteoclasts and neutro...
