Sun, Yangyang Yu, Lei Liu, Chengxi Ye, Shanting Chen, Wei Li, Dechang Huang, Weiren
Published in
Journal of Translational Medicine
Background COVID-19 has spread rapidly around the world, affecting a large percentage of the population. When lifting certain mandatory measures for an economic restart, robust surveillance must be established and implemented, with nucleic acid detection for SARS-CoV-2 as an essential component. Methods We tried to develop a one-tube detection plat...
Moin, Abu Saleh Md Nandakumar, Manjula Sathyapalan, Thozhukat Atkin, Stephen L Butler, Alexandra E
Published in
Journal of translational medicine
Zhang, Xinxin Qin, Yating Wan, Xiaoning Liu, Hao Lv, Chao Ruan, Weibin He, Lin Lu, Li Guo, Xiaomei
Published in
Journal of Translational Medicine
BackgroundAtherosclerosis is a chronic vascular disease posing a great threat to public health. We investigated whether rosuvastatin (RVS) enhanced autophagic activities to inhibit lipid accumulation and polarization conversion of macrophages and then attenuate atherosclerotic lesions.MethodsAll male Apolipoprotein E-deficient (ApoE−/−) mice were f...
Watson, Chris J. Gallagher, Joe Wilkinson, Mark Russell-Hallinan, Adam Tea, Isaac James, Stephanie O’Reilly, James O’Connell, Eoin Zhou, Shuaiwei Ledwidge, Mark
...
Published in
Journal of Translational Medicine
BackgroundThe purpose of this study was to investigate the utility of BNP, hsTroponin-I, interleukin-6, sST2, and galectin-3 in predicting the future development of new onset heart failure with preserved ejection fraction (HFpEF) in asymptomatic patients at-risk for HF.MethodsThis is a retrospective analysis of the longitudinal STOP-HF study of thi...
Benedetti, Francesca Curreli, Sabrina Gallo, Robert C. Zella, Davide
Published in
Journal of Translational Medicine
BackgroundStudies of molecular mechanisms underlying tumor cell signaling highlighted a critical role for kinases in carcinogenesis and cancer progression. To this regard, protein kinases regulates a number of critical cellular pathways by adding phosphate groups to specific substrates. For this reason, their involvement in the complex interactions...
Zhong, Qihang Lu, Minzhen Yuan, Wanqiong Cui, Yueyi Ouyang, Hanqiang Fan, Yong Wang, Zhaohui Wu, Congying Qiao, Jie Hang, Jing
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Published in
Journal of Translational Medicine
BackgroundCopy number variation (CNV) suggests genetic changes in malignant tumors. Abnormal expressions of long non-coding RNAs (lncRNAs) resulted from genomic and epigenetic abnormalities play a driving role in tumorigenesis of cervical cancer. However, the role of lncRNAs-related CNV in cervical cancer remained largely unclear.MethodsThe data of...
Gou, Xin Wu, Jing Huang, Mingqing Weng, Yuting Yang, Tongxin Chen, Tao Li, Guiqing Fang, Kewei
Published in
Journal of Translational Medicine
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12967-021-02719-3
Benna, Clara Rajendran, Senthilkumar Spiro, Giovanna Menin, Chiara Dall’Olmo, Luigi Rossi, Carlo Riccardo Mocellin, Simone
Published in
Journal of Translational Medicine
BackgroundMelanoma is the deadliest of skin cancers and has an increasing annual incidence worldwide. It is a multi-factorial disease most likely arising from both genetic predisposition and environmental exposure to ultraviolet light. Genetic variability of the components of the biological circadian clock is recognized to be a risk factor for diff...
Schöning, Verena Liakoni, Evangelia Baumgartner, Christine Exadaktylos, Aristomenis K. Hautz, Wolf E. Atkinson, Andrew Hammann, Felix
Published in
Journal of Translational Medicine
BackgroundClinical risk scores and machine learning models based on routine laboratory values could assist in automated early identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients at risk for severe clinical outcomes. They can guide patient triage, inform allocation of health care resources, and contribute to the i...
Ilan, Yaron
Published in
Journal of Translational Medicine
The vast majority of good science and excellent ideas do not translate into products. Many good products that have the potential to assist in diagnosis and therapy do not mature into everyday care. This often becomes a source of frustration for innovators, academic institutions, companies both small and large, and investors. The “innovation paradox...