Published in Journal of the Royal Society, Interface
Monotrichous bacteria on surfaces exhibit complex spinning movements. Such spinning motility is often a part of the surface detachment launch sequence of these cells. To understand the impact of spinning motility on bacterial surface interactions, we develop a hydrodynamic model of a surface-bound bacterium, which reproduces behaviours that we obse...
Published in Journal of The Royal Society Interface
The recognition process between a protein and a partner represents a significant theoretical challenge. In silico structure-based drug design carried out with nothing more than the three-dimensional structure of the protein has led to the introduction of many compounds into clinical trials and numerous drug approvals. Central to guiding the discove...
Published in Journal of the Royal Society, Interface
Lateral inhibition provides the basis for a self-organizing patterning system in which distinct cell states emerge from an otherwise uniform field of cells. The development of the microchaete bristle pattern on the notum of the fruitfly, Drosophila melanogaster, has long served as a popular model of this process. We recently showed that this bristl...
Published in Journal of the Royal Society, Interface
The power of electronic computation is due in part to the development of modular gate structures that can be coupled to carry out sophisticated logical operations and whose performance can be readily modelled. However, the equivalences between electronic and biochemical operations are far from obvious. In order to help cross between these disciplin...
Published in Journal of the Royal Society, Interface
Understanding the interaction between epidemiological and evolutionary dynamics for antigenically variable pathogens remains a challenge, particularly if analytical insight is wanted. In particular, while a variety of relatively complex simulation models have reproduced the evolutionary dynamics of influenza, simpler models have given less satisfyi...
Published in Journal of the Royal Society, Interface
Tissue formation is determined by uncountable biochemical signals between cells; in addition, physical parameters have been shown to exhibit significant effects on the level of the single cell. Beyond the cell, however, there is still no quantitative understanding of how geometry affects tissue growth, which is of much significance for bone healing...
