Trimpin, Sarah Inutan, Ellen D. Karki, Santosh Elia, Efstathios A. Zhang, Wen-Jing Weidner, Steffen M. Marshall, Darrell D. Hoang, Khoa Lee, Chuping Davis, Eric T. J.
...
Published in
Journal of The American Society for Mass Spectrometry
Exceptional ion mobility spectrometry mass spectrometry (IMS-MS) developments by von Helden, Jarrold, and Clemmer provided technology that gives a view of chemical/biological compositions previously not achievable. The ionization method of choice used with IMS-MS has been electrospray ionization (ESI). In this special issue contribution, we focus o...
Chen, Xi Raab, Shannon A. Poe, Timothy Clemmer, David E. Larriba-Andaluz, Carlos
Published in
Journal of The American Society for Mass Spectrometry
The strong synergy arising from coupling two orthogonal analytical techniques such as ion mobility and mass spectrometry can be used to separate complex mixtures and determine structural information of analytes in the gas phase. A tandem study is performed using two systems with different gases and pressures to ascertain gas-phase conformations of ...
Nie, Ben Henion, Jack Ryona, Imelda
Published in
Journal of The American Society for Mass Spectrometry
The focus of this critical insight article is a brief overview of analytical challenges the cannabis industry faces and how analytical chemists have new opportunities to demonstrate the merits of employing mass spectrometry for the chemical analysis of cannabis and its products. The current range of cannabis products extends from recreational use t...
Draper, Benjamin E. Jarrold, Martin F.
Published in
Journal of The American Society for Mass Spectrometry
Charge detection mass spectrometry (CDMS) is an important tool for measuring mass distributions for high mass samples and heterogeneous mixtures. In CDMS, single ions are trapped and their m/z and charge are measured simultaneously. As a single particle technique, the average signal must be optimized to maximize the number of single ion trapping ev...
Reinecke, Tobias Davis, Austen L. Clowers, Brian H.
Published in
Journal of The American Society for Mass Spectrometry
In a standard single averaged, drift tube ion mobility spectrometry (IMS) experiment, typically less than 1% of the ions are utilized, with the rest of the ions neutralizing on a closed ion gate or ion optic element. Though some efforts at lower pressures (e.g., 4 Torr) have been made to address this issue by concentrating ions prior to release int...
Conant, Christopher R. Fuller, Daniel R. El-Baba, Tarick J. Zhang, Zhichao Russell, David H. Clemmer, David E.
Published in
Journal of The American Society for Mass Spectrometry
We report ion mobility spectrometry and mass spectrometry studies of the non-enzymatic step-by-step degradation of substance P (subP), an 11-residue neuropeptide, with the sequence Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-Phe8-Gly9-Leu10-Met11-NH2, in ethanol. At elevated solution temperatures (55 to 75 °C), several reactions are observed, including a pr...
Conant, Christopher R. Fuller, Daniel R. Zhang, Zhichao Woodall, Daniel W. Russell, David H. Clemmer, David E.
Published in
Journal of The American Society for Mass Spectrometry
The work presented below is related to our companion paper in this issue, entitled: Substance P in solution: trans-to-cis configurational changes of penultimate prolines initiate non-enzymatic peptide bond cleavages. Two-dimensional ion mobility spectrometry (IMS-IMS) and mass spectrometry techniques are used to investigate structural transitions f...
Majuta, Sandra N. Li, Chong Jayasundara, Kinkini Kiani Karanji, Ahmad Attanayake, Kushani Ranganathan, Nandhini Li, Peng Valentine, Stephen J.
Published in
Journal of The American Society for Mass Spectrometry
Rapid, solution-phase hydrogen/deuterium exchange (HDX) coupled with mass spectrometry (MS) is demonstrated as a means for distinguishing small-molecule metabolites. HDX is achieved using capillary vibrating sharp-edge spray ionization (cVSSI) to allow sufficient time for reagent mixing and exchange in micrometer-sized droplets. Different compounds...
Ujma, Jakub Ropartz, David Giles, Kevin Richardson, Keith Langridge, David Wildgoose, Jason Green, Martin Pringle, Steven
Published in
Journal of The American Society for Mass Spectrometry
There is increasing biopharmaceutical interest in oligosaccharides and glycosylation. A key requirement for these sample types is the ability to characterize the chain length, branching, type of monomers, and importantly stereochemistry and anomeric configuration. Herein, we showcase the multi-function capability of a cyclic ion mobility (cIM) sepa...
Bowers, Michael T. Russell, David H. Bierbaum, Veronica M.
Published in
Journal of The American Society for Mass Spectrometry
