Jin, Yutong Diffee, Gary M. Colman, Ricki J. Anderson, Rozalyn M. Ge, Ying
Published in
Journal of The American Society for Mass Spectrometry
Sarcomeric proteins, including myofilament and Z-disk proteins, play critical roles in regulating muscle contractile properties. A variety of isoforms and post-translational modifications (PTMs) of sarcomeric proteins have been shown to be associated with modulation of muscle functions and the occurrence of muscle diseases. Non-human primates (NHPs...
Schneck, Nicole A. Ivleva, Vera B. Rosales-Zavala, Erwin Wang, Xiangchun Gollapudi, Deepika Cooper, Jonathan W. Lei, Q. Paula
Published in
Journal of The American Society for Mass Spectrometry
A hemagglutinin stabilized stem nanoparticle (HA-SS-np) that is designed to provide broad protection against influenza is being developed as a potential vaccine. During an early formulation screening study, reducing gel (rCGE) analysis indicated product degradation in a few candidate buffers at the first-week accelerated stability point, whereas no...
Cox, Richard M. Armentrout, P. B.
Published in
Journal of The American Society for Mass Spectrometry
The reaction of atomic thorium cations with deuterated water as a function of kinetic energy from thermal to 10 eV was studied using guided ion beam tandem mass spectrometry. At thermal energies, both ThO+ + D2 and DThO+ + D are formed in barrierless exothermic processes and reproduce results in the literature obtained using ion cyclotron resonance...
Jiang, Kang Gachumi, George Poudel, Asmita Shurmer, Bryn Bashi, Zafer El-Aneed, Anas
Published in
Journal of The American Society for Mass Spectrometry
Phytosterols and tocopherols are essential for plant biochemistry, and they possess beneficial health effects for humans. Evaluating the tandem mass spectrometric (MS/MS) behavior of phytosterols and tocopherols is needed for the development of a qualitative and quantitative method for these biologically active plant metabolites. Herein, the MS/MS ...
Cleary, Jessica L. Luu, Gordon T. Pierce, Emily C. Dutton, Rachel J. Sanchez, Laura M.
Published in
Journal of The American Society for Mass Spectrometry
Multispecies microbiome systems are known to be closely linked to human, animal, and plant life processes. The growing field of metabolomics presents the opportunity to detect changes in overall metabolomic profiles of microbial species interactions. These metabolomic changes provide insight into function of metabolites as they correlate to differe...
Boukid, Fatma Prandi, Barbara Faccini, Andrea Sforza, Stefano
Published in
Journal of The American Society for Mass Spectrometry
Resistance of gluten to gastrointestinal digestion is involved in immune-mediated adverse reactions to wheat, since several peptides produced by the incomplete digestion are able to trigger, in predisposed individuals, the immune response responsible, for instance, of celiac disease (CD) and other adverse reactions. Even if several peptides have be...
Bridge, Candice Marić, Mark
Published in
Journal of The American Society for Mass Spectrometry
The analysis of lubricant evidence is a recent development in sexual assault investigations and in the absence of any biological evidence may assist in linking an assailant to the victim or crime scene. An ambient ionization technique, high-resolution direct analysis in real-time mass spectrometry (HR-DART-MS), was employed to characterize a sample...
Lubeckyj, Rachele A. Basharat, Abdul Rehman Shen, Xiaojing Liu, Xiaowen Sun, Liangliang
Published in
Journal of The American Society for Mass Spectrometry
Capillary zone electrophoresis-electrospray ionization-tandem mass spectrometry (CZE-ESI-MS/MS) has attracted attention recently for top-down proteomics because it can achieve highly efficient separation and very sensitive detection of proteins. However, separation window and sample loading volume of CZE need to be boosted for a better proteome cov...
Devereaux, Zachary J. He, C. C. Zhu, Y. Roy, H. A. Cunningham, N. A. Hamlow, L. A. Berden, G. Oomens, J. Rodgers, M. T.
Published in
Journal of The American Society for Mass Spectrometry
The 2′-substituent is the primary distinguishing feature between DNA and RNA nucleosides. Modifications to this critical position, both naturally occurring and synthetic, can produce biologically valuable nucleoside analogues. The unique properties of fluorine make it particularly interesting and medically useful as a synthetic nucleoside modificat...
Valadbeigi, Younes Ilbeigi, Vahideh Michalczuk, Bartosz Sabo, Martin Matejcik, Stefan
Published in
Journal of The American Society for Mass Spectrometry
Protonation, hydration, and cluster formation of ammonia, formaldehyde, formic acid, acetone, butanone, 2-ocatanone, 2-nonanone, acetophenone, ethanol, pyridine, and its derivatives were studied by IMS-TOFMS technique equipped with a corona discharge ion source. It was found that tendency of the protonated molecules, MH+, to participate in hydratio...
