Liu, Yingman Huang, Wenkai Dai, Ke Liu, Ni Wang, Jiaqi Lu, Xiaoying Ma, Jiaojiao Zhang, Manman Xu, Mengqi Long, Xu
...
Published in
Journal of Oral Microbiology
Background Periodontitis is a chronic multifactorial inflammatory disease. Porphyromonas gingivalis is a primary periopathogen in the initiation and development of periodontal disease. Evidence has shown that P. gingivalis is associated with systemic diseases, including IBD and fatty liver disease. Inflammatory response is a key feature of diseases...
Cho, Eunji Hwang, Ji-Yeon Park, Jae Sung Oh, Daehyun Oh, Dong-Chan Park, Hyeung-Geun Shin, Jongheon Oh, Ki-Bong
Published in
Journal of Oral Microbiology
Background Streptococcus mutans , an important Gram-positive pathogen in dental caries, uses sortase A (SrtA) to anchor surface proteins to the bacterial cell wall, thereby promoting biofilm formation and attachment to the tooth surface. Design Based on activity-guided separation, inhibitors of S. mutans SrtA were isolated from Juniperus chinensis ...
Vieira Lima, Camilla Pedrosa Grisi, Daniela Corrêa Guimarães, Maria Do Carmo Machado Salles, Loise Pedrosa Kruly, Paula de Castro Do, Thuy Dos Anjos Borges, Luiz Gustavo Dame-Teixeira, Naile
Published in
Journal of Oral Microbiology
Objectives This study aimed to investigate oral microbial signatures associated with hyperglycaemia, by correlating the oral microbiome with three glycaemic markers. Potential association between clinical parameters and oral bacterial taxa that could be modulating the hyperglycaemic microbiome was also explored. Methods Twenty-three individuals dia...
Qin, Han Li, Guangyue Xu, Xiaohui Zhang, Chuangwei Zhong, Wenjie Xu, Shihan Yin, Yuanyuan Song, Jinlin
Published in
Journal of Oral Microbiology
Periodontitis is among most common human inflammatory diseases and characterized by destruction of tooth-supporting tissues that will eventually lead to tooth loss. Diabetes mellitus (DM) is a group of metabolic disorders characterized by chronic hyperglycemia which results from defects in insulin secretion and/or insulin resistance. Numerous studi...
Pan, Ting Liu, Feng-Shou Lin, Huancai Zhou, Yan
Published in
Journal of Oral Microbiology
Objective Biofilm formation under cariogenic conditions contributes to dental caries development, in which Streptococcus mutans ( S. mutans ) is regarded as the major cariogenic bacteria. Here, we synthesized a series of imidazolium salts. Their properties of antimicrobial and anti-biofilm were investigated. Methods The microdilution method crystal...
Baraniya, Divyashri Chitrala, Kumaraswamy Naidu Al-Hebshi, Nezar Noor
Published in
Journal of Oral Microbiology
Background We have recently demonstrated that health-associated oral bacteria Streptococcus mitis , Neisseria flavescens , and Haemophilus parainfluenzae induce cytotoxicity in oral squamous cell carcinoma (OSCC) cell lines and downregulate CD36, a cancer-assocaited gene. Aim To explore the effect of these three species on global transcriptome of O...
Lau, Hui-Ching Shen, Yujie Huang, Huiying Yuan, Xiaohui Ji, Mengyou Gong, Hongli Hsueh, Chi-Yao Zhou, Liang
Published in
Journal of oral microbiology
To clarify the absolute abundance of microbial communities on hypopharyngeal squamous cell carcinoma and their correlation to those in the oropharynx. Clinical data, swabs, and tissue samples from 27 HPSCC patients were collected in this study and divided into three sampling groups: 19 oropharyngeal mucosa (OPM), 27 hypopharyngeal carcinomas tissue...
Widyarman, Armelia Sari Udawatte, Nadeeka S Roeslan, Moehamad Orliando Rizal, Muhammad Ihsan Richi, Mario Kusnoto, Joko Seneviratne, Chaminda Jayampath
Published in
Journal of oral microbiology
This prospective clinical study aim was to analyze the effect of the probiotic Lactobacillus reuteri Prodentis lozenges on salivary microbiome of subjects wearing fixed orthodontic appliances. Saliva samples were collected prior to consumption and 14th-day post probiotic lozenges consumption (n=40, age 18-23). Oral hygiene index-score (OHI-S) and p...
Zhang, Lingjun Shen, Yan Qiu, Lili Yu, Fangzheng Hu, Xiangyu Wang, Min Sun, Yan Pan, Yihuai Zhang, Keke
Published in
Journal of oral microbiology
SCH-79797 was recently shown to be a broad-spectrum antibacterial agent with a dual-bactericidal mechanism. However, its anti-biofilm effect remains unknown. To investigate the effect of SCH-79797 on the biofilm formation of the cariogenic Streptococcus mutans. Crystal violet staining, colony forming units count and MTT assays (for cell metabolic a...
Sekundo, Caroline Langowski, Eva Wolff, Diana Boutin, Sébastien Frese, Cornelia
Published in
Journal of oral microbiology
To investigate associations between oral health-related conditions and the oral microbiome in a representative study sample of centenarians. Clinical and microbial parameters from 54 centenarians were assessed in the Heidelberg Dental Centenarian Study. Plaque and salivary samples were collected, and the microbiota was characterized by 16S rRNA gen...
