Published in Journal of optimization theory and applications
In this paper, we study the competition of healthcare institutions for medical supplies in emergencies caused by natural disasters. In particular, we develop a two-stage procurement planning model in a random environment. We consider a pre-event policy, in which each healthcare institution seeks to minimize the purchasing cost of medical items and ...
Published in Journal of optimization theory and applications
This article deals with an economic production quantity (EPQ) model with deterioration under the effect of environmental pollution in fuzzy environment. First of all, we develop a pollution generation (PG) model with the help of existing initial pollution status of the environment, and then we use it as an essential constraint in the proposed EPQ m...
Published in Journal of optimization theory and applications
In this paper, we study derivatives of powers of Euclidean norm. We prove their Hölder continuity and establish explicit expressions for the corresponding constants. We show that these constants are optimal for odd derivatives and at most two times suboptimal for the even ones. In the particular case of integer powers, when the Hölder continuity tr...
We present a new theoretical analysis of local superlinear convergence of classical quasi-Newton methods from the convex Broyden class. As a result, we obtain a significant improvement in the currently known estimates of the convergence rates for these methods. In particular, we show that the corresponding rate of the Broyden-Fletcher-Goldfarb-Shan...
In this paper, we study the iteration complexity of cubic regularization of Newton method for solving composite minimization problems with uniformly convex objective. We introduce the notion of second-order condition number of a certain degree and justify the linear rate of convergence in a nondegenerate case for the method with an adaptive estimat...
Published in Journal of optimization theory and applications
In this paper, we study robust necessary optimality conditions for a nondifferentiable complex fractional programming with uncertain data. A robust counterpart of uncertain complex fractional programming is introduced in the worst-case scenario. The concept of robust optimal solution of the uncertain complex fractional programming is introduced by ...
Published in Journal of Optimization Theory and Applications
The aim of this article is to understand how to apply partial or total containment to SIR epidemic model during a given finite time interval in order to minimize the epidemic final size, that is the cumulative number of cases infected during the complete course of an epidemic. The existence and uniqueness of an optimal strategy are proved for this ...
Published in Journal of Optimization Theory and Applications
Providing the optimal dosing strategy of a drug for an individual patient is an important task in pharmaceutical sciences and daily clinical application. We developed and validated an optimal dosing algorithm (OptiDose) that computes the optimal individualized dosing regimen for pharmacokinetic–pharmacodynamic models in substantially different scen...
Published in Journal of Optimization Theory and Applications
We study minimization of a structured objective function, being the sum of a smooth function and a composition of a weakly convex function with a linear operator. Applications include image reconstruction problems with regularizers that introduce less bias than the standard convex regularizers. We develop a variable smoothing algorithm, based on th...
Published in Journal of optimization theory and applications
We review and discuss results obtained through an application of tools of nonlinear optimal control to biomedical problems. We discuss various aspects of the modeling of the dynamics (such as growth and interaction terms), modeling of treatment (including pharmacometrics of the drugs), and give special attention to the choice of the objective funct...
