Malpetti, Maura Kaalund, Sanne S Tsvetanov, Kamen A Rittman, Timothy Briggs, Mayen Allinson, Kieren S J Passamonti, Luca Holland, Negin Jones, P Simon Fryer, Tim D
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by neuroglial tau pathology. A new staging system for PSP pathology postmortem has been described and validated. We used a data-driven approach to test whether postmortem pathologic staging in PSP can be reproduced in vivo with 18F-flortaucipir PET. Methods: Forty-tw...
Crompton, Joseph G Armstrong, Wesley R Eckardt, Mark A Seyedroudbari, Ameen Tap, William D Dry, Sarah M Abt, Evan R Calais, Jeremie Herrmann, Ken Czernin, Johannes
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The purpose of this study was to evaluate 18F-FLT PET/CT as an early prognostic imaging biomarker of long-term overall survival and disease-specific survival (DSS) in soft-tissue sarcoma (STS) patients treated with neoadjuvant therapy (NAT) and surgical resection. Methods: This was a 10-y follow-up of a previous single-center, single-arm prospectiv...
Vonk, Jasper de Wit, Jaron G Voskuil, Floris J Tang, Yang Hang Hooghiemstra, Wouter T R Linssen, Matthijs D van den Broek, Evert Doff, Jan J de Visscher, Sebastiaan A H J Schepman, Kees-Pieter
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
In most oral cancer patients, surgical treatment includes resection of the primary tumor combined with excision of lymph nodes (LNs), either for staging or for treatment. All LNs harvested during surgery require tissue processing and subsequent microscopic histopathologic assessment to determine the nodal stage. In this study, we investigated the u...
Eriksson, Olof Velikyan, Irina Haack, Torsten Bossart, Martin Laitinen, Iina Larsen, Philip J Berglund, Jan Erik Antoni, Gunnar Johansson, Lars Pierrou, Stefan
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The glucagonlike peptide-1 receptor (GLP1R) is a gut hormone receptor, intricately linked to regulation of blood glucose homeostasis via several mechanisms. It is an established and emergent drug target in metabolic disease. The PET radioligand 68Ga-DO3A-VS-exendin4 (68Ga-exendin4) has the potential to enable longitudinal studies of GLP1R in the hu...
Tamborino, Giulia Perrot, Yann De Saint-Hubert, Marijke Struelens, Lara Nonnekens, Julie Jong, Marion De Konijnenberg, Mark W Villagrasa, Carmen
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The aim of this study was to build a simulation framework to evaluate the number of DNA double-strand breaks (DSBs) induced by in vitro targeted radionuclide therapy (TRT). This work represents the first step toward exploring underlying biologic mechanisms and the influence of physical and chemical parameters to enable a better response prediction ...
Seifert, Robert Sandach, Patrick Kersting, David Fendler, Wolfgang P Hadaschik, Boris Herrmann, Ken Sunderland, John J Pollard, Janet H
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Molecular tumor volume (MTV) is a parameter of interest in prostate cancer for assessing total disease burden on prostate-specific membrane antigen (PSMA) PET. Although software segmentation tools can delineate whole-body MTV, a necessary step toward meaningful monitoring of total tumor burden and treatment response through PET is establishing the ...
Farwell, Michael D Gamache, Raymond F Babazada, Hasan Hellmann, Matthew D Harding, James J Korn, Ron Mascioni, Alessandro Le, William Wilson, Ian Gordon, Michael S
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
There is a need for in vivo diagnostic imaging probes that can noninvasively measure tumor-infiltrating CD8+ leukocytes. Such imaging probes could be used to predict early response to cancer immunotherapy, help select effective single or combination immunotherapies, and facilitate the development of new immunotherapies or immunotherapy combinations...
Selvaraj, Senthil Margulies, Kenneth B Dugyala, Supritha Schubert, Erin Tierney, Ann Arany, Zoltan Pryma, Daniel A Shah, Svati H Rame, J Eduardo Kelly, Daniel P
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The ketogenic diet (KD) is the standard of care to achieve myocardial glucose suppression (MGS) for assessing inflammation using 18F-FDG PET. However, failure to suppress physiologic glucose uptake remains a significant diagnostic barrier. Although extending the duration of KD may be effective, exogenously delivered ketones may provide a convenient...
Ferdinandus, Justin Costa, Pedro Fragoso Kessler, Lukas Weber, Manuel Hirmas, Nader Kostbade, Karina Bauer, Sebastian Schuler, Martin Ahrens, Marit Schildhaus, Hans-Ulrich
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Fibroblast activation protein (FAP) is overexpressed in several solid tumors and therefore represents an attractive target for radiotheranostic applications. Recent investigations demonstrated rapid and high uptake of small-molecule inhibitors of FAP (68Ga-FAPI-46) for PET imaging. Here, we report our initial experience of the feasibility and safet...
Bag, Asim K Wing, Melissa N Sabin, Noah D Hwang, Scott N Armstrong, Gregory T Han, Yuanyuan Li, Yimei Snyder, Scott E Robinson, Giles W Qaddoumi, Ibrahim
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Differentiating tumor recurrence or progression from pseudoprogression during surveillance of pediatric high-grade gliomas (PHGGs) using MRI, the primary imaging modality for evaluation of brain tumors, can be challenging. The aim of this study was to evaluate whether 11C-methionine PET, a molecular imaging technique that detects functionally activ...
