Rydén, Tobias Van Essen, Martijn Marin, Ida Svensson, Johanna Bernhardt, Peter
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The aims of this study were to decrease the 177Lu-SPECT acquisition time by reducing the number of projections and to circumvent image degradation by adding deep-learning-generated synthesized projections. Methods: We constructed a deep convolutional U-net-shaped neural network for generation of synthetic intermediate projections (CUSIPs). The numb...
Bragina, Olga von Witting, Emma Garousi, Javad Zelchan, Roman Sandström, Mattias Orlova, Anna Medvedeva, Anna Doroshenko, Artem Vorobyeva, Anzhelika Lindbo, Sarah
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Radionuclide molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression may help to stratify breast and gastroesophageal cancer patients for HER2-targeting therapies. Albumin-binding domain-derived affinity proteins (ADAPTs) are a new type of small (46-59 amino acids) protein useful as probes for molecular imaging. The aim...
Brechbiel, Martin W.
Published in
Journal of Nuclear Medicine
Werner, Rudolf A Derlin, Thorsten Rowe, Steven P Bundschuh, Lena Sheikh, Gabriel T Pomper, Martin G Schulz, Sebastian Higuchi, Takahiro Buck, Andreas K Bengel, Frank M
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Recently, a standardized framework system for interpreting somatostatin receptor (SSTR)-targeted PET/CT, termed the SSTR reporting and data system (RADS) 1.0, was introduced, providing reliable standards and criteria for SSTR-targeted imaging. We determined the interobserver reliability of SSTR-RADS for interpretation of 68Ga-DOTATOC PET/CT scans i...
Nicolay, Nils H Rühle, Alexander Wiedenmann, Nicole Niedermann, Gabriele Mix, Michael Weber, Wolfgang A Baltas, Dimos Werner, Martin Kayser, Gian Grosu, Anca-L
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Tumor hypoxia in head-and-neck squamous cell carcinoma (HNSCC) leads to an immunosuppressive microenvironment and reduces the response to radiotherapy. In this prospective imaging trial, we investigated potential interactions between functional hypoxia imaging and infiltrating lymphocyte levels as a potential predictor for treatment response in HNS...
Haseltine, Katherine N. Chukir, Tariq Smith, Pinar J. Jacob, Justin T. Bilezikian, John P. Farooki, Azeez
Published in
Journal of Nuclear Medicine
Bone mineral density (BMD) measurement by dual-energy x-ray absorptiometry (DXA) is an internationally accepted standard-of-care screening tool used to assess fragility-fracture risk. Society guidelines have recommended which populations may benefit from DXA screening and the use of the fracture risk assessment tool (FRAX) to guide decisions regard...
Lee, Sang-Gyu Kalidindi, Teja Muralidhar Lou, Hanzhi Gangangari, Kishore Punzalan, Blesida Bitton, Ariana Lee, Casey J Vargas, Hebert A Park, Soobin Bodei, Lisa
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
With the successful development and increased use of targeted radionuclide therapy for treating cancer comes the increased risk of radiation injury to bone marrow-both direct suppression and stochastic effects, leading to neoplasia. Herein, we report a novel radioprotector drug, a liposomal formulation of γ-tocotrienol (GT3), or GT3-Nano for short,...
Viitanen, Riikka Moisio, Olli Lankinen, Petteri Li, Xiang-Guo Koivumäki, Mikko Suilamo, Sami Tolvanen, Tuula Taimen, Kirsi Mali, Markku Kohonen, Ia
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Sialic acid-binding immunoglubulinlike lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1. A 68Ga-labeled peptide of Siglec-9, 68Ga-DOTA-Siglec-9, holds promise as a novel PET tracer for imaging of inflammation. This first-in-humans study investigated the safety, tolerability, biodistribution, and radiation dosimetry of this radiopharma...
Naganawa, Mika Nabulsi, Nabeel Henry, Shannan Matuskey, David Lin, Shu-Fei Slieker, Lawrence Schwarz, Adam J Kant, Nancy Jesudason, Cynthia Ruley, Kevin
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
This was a first-in-human study of the PET radiotracer 11C-LSN3172176 for the muscarinic acetylcholine receptor subtype M1. The objectives of the study were to determine the appropriate kinetic model to quantify binding of the tracer to M1 receptors, and the reliability of the chosen quantification method. Methods: Six healthy subjects completed th...
Galldiks, Norbert Abdulla, Diana S Y Scheffler, Matthias Wolpert, Fabian Werner, Jan-Michael Hüllner, Martin Stoffels, Gabriele Schweinsberg, Viola Schlaak, Max Kreuzberg, Nicole
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
We investigated the value of O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) PET for treatment monitoring of immune checkpoint inhibition (ICI) or targeted therapy (TT) alone or in combination with radiotherapy in patients with brain metastasis (BM) since contrast-enhanced MRI often remains inconclusive. Methods: We retrospectively identified 40 patient...
