Miaskowski, Christine Topp, Kimberly Conley, Yvette P. Paul, Steven M. Melisko, Michelle Schumacher, Mark Chesney, Margaret Abrams, Gary Levine, Jon D. Kober, Kord M.
...
Published in
Journal of Neuroimmunology
• Paclitaxel-induced peripheral neuropathy (PIPN) is associated with Paclitaxel treatment • Differential gene expression was associated with PIPN in breast cancer survivors. • Perturbations of neuroinflammatory-related pathways were identified between survivors. • Transcriptome profile was similar to other pre-clinical and clinical studies.
Savage, Sharon A. Irani, Sarosh R. Leite, M. Isabel Zeman, Adam Z.
Published in
Journal of Neuroimmunology
• Transient epileptic amnesia (TEA) is a recently defined syndrome of late life epilepsy. • Its main manifestation is recurrent amnesia, often on awakening. • NMDA receptor encephalitis (NMDARE) has a widening phenotype. • We describe a case of NMDARE presenting as TEA. • TEA is sometime caused by an autoimmune process.
Maddison, Paul Titulaer, Maarten J. Verschuuren, Jan J. Gozzard, Paul Lang, Bethan Irani, Sarosh R. Sabater, Lidia Graus, Francesc Murray, Andrea Chapman, Caroline J.
...
Published in
Journal of Neuroimmunology
• SOX2 antibodies only seen in small-cell lung cancer (SCLC), not other tumours • 61% of patients with Lambert-Eaton syndrome and SCLC have SOX2 antibodies. • Patients with paraneoplastic disorders only have SOX2 antibodies if SCLC is present.
Debnath, Monojit Nagappa, Madhu Subbanna, Manjula Sundaravadivel, Pandarisamy Talukdar, Pinku Mani Shivakumar, Venkataram Wahatule, Rahul Debprasad Dutta Binukumar, B. Sinha, Sanjib
...
Published in
Journal of Neuroimmunology
The etiopathogenesis of Guillain Barré Syndrome (GBS) is inadequately understood. The role of immuno-inflammatory Th17 pathway was examined in GBS patients by genetic, gene expression and biochemical studies. Genotyping of G197A single nucleotide polymorphism within IL17 gene was carried out by PCR-RFLP method in 220 GBS patients. Quantification of...
Detrick, Barbara Gangaputra, Sapna Palsgrove, Doreen N. Heaney, Christopher D. Hooks, John J. Nida Sen, H.
Published in
Journal of Neuroimmunology
• IL-6 and CXCL9 are both elevated in AIR patient sera. • The presence and concentration of IL-6 and CXCL9 correlate with AIR patient disease severity. • These cytokines may play a prominent role in the initiation and development of inflammation and autoimmunity. • The data provides evidence for activated inflammatory processes in AIR.
Ganesan, Priya Chandwani, Manisha N. Creisher, Patrick S. Bohn, Larissa O'Donnell, Lauren A.
Published in
Journal of Neuroimmunology
• The role of the anti-viral cytokine interferon-gamma (IFNγ) is investigated during a neonatal viral infection in CNS neurons. • IFNγ did not prevent mortality in neonates, but it slowed disease progression. • IFNγ reduced infiltration of neutrophils, macrophages, and T cells in the neonatal CNS. • Both adult and neonatal mice expressed Th1-like c...
Bonnan, Mickael Barroso, Bruno Demasles, Stéphanie Krim, Elsa Marasescu, Raluca Miquel, Marie
Published in
Journal of neuroimmunology
HIV infects the central nervous system (CNS) during primary infection and persists in resident macrophages. CNS infection initiates a strong local immune response that fails to control the virus but is responsible for by-stander lesions involved in neurocognitive disorders. Although highly active anti-retroviral therapy now offers an almost complet...
Disano, Krista Phares, Timothy Bergmann, Cornelia
Published in
Journal of Neuroimmunology
Gehan A. Mostafa Dalia F. El-Sherif Laila Y. Al-Ayadhi
Published in
Journal of Neuroimmunology
de Andrés, Clara Tejera-Alhambra, Marta Alonso, Bárbara Valor, Lara Teijeiro, Roseta Ramos-Medina, Rocío Mateos, Dolores Faure, Florence Sánchez-Ramón, Silvia
Published in
Journal of Neuroimmunology
•A new subset of perforin-producing regulatory B cells enriched at CNS during MS relapse is described.•To our knowledge, this is the first report demonstrating perforin expression by B cells.•Our data may add on cell contact mechanisms of immune suppression by BReg during MS relapse.
