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Immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in patients with primary brain tumors: a prospective cohort study

Published in Journal of Neuro-Oncology

Purpose Immunogenicity of Covid-19 vaccines may be negatively impacted by anti-cancer treatment. The management of primary brain tumors (PBTs) routinely includes temozolomide and steroids, which are immune-suppressive. We aimed to determine the rate of seropositivity in PBT patients following receipt of two doses of the BNT162b2 vaccine. Methods We...

Independently validated sex-specific nomograms for predicting survival in patients with newly diagnosed glioblastoma: NR...

Published in Journal of neuro-oncology

Glioblastoma (GBM) is the most common primary malignant brain tumor. Sex has been shown to be an important prognostic factor for GBM. The purpose of this study was to develop and independently validate sex-specific nomograms for estimation of individualized GBM survival probabilities using data from 2 independent NRG Oncology clinical trials. This ...

Reforming support systems of newly diagnosed brain cancer patients: a systematic review

Published in Journal of Neuro-Oncology

Purpose Despite the increasing incidence of currently incurable brain cancer, limited resources are placed in patients’ support systems, with reactive utilisation late in the disease course, when physical and psychological symptoms have peaked. Based on patient-derived data and emphasis on service improvement, this review investigated the structure...

Using chimeric antigen receptor T-cell therapy to fight glioblastoma multiforme: past, present and future developments

Published in Journal of Neuro-Oncology

Introduction Glioblastoma multiforme (GBM) constitutes one of the deadliest tumors to afflict humans, although it is still considered an orphan disease. Despite testing multiple new and innovative therapies in ongoing clinical trials, the median survival for this type of malignancy is less than two years after initial diagnosis, regardless of thera...

Correction to: Surgical strategies for older patients with glioblastoma

Published in Journal of Neuro-Oncology

Stereotactic radiosurgery for melanoma brain metastases: dose-size response relationship in the era of immunotherapy

Published in Journal of Neuro-Oncology

Purpose/Objective(s) To determine, for intact melanoma brain metastases (MBM) treated with single-fraction stereotactic radiosurgery (SRS), whether planning parameter peripheral dose per lesion diameter (PDLDm, Gy/mm) and lesion control (LC) differs with versus without immunotherapy (IO). Materials/Methods We performed a retrospective analysis of p...

Increased proliferation is associated with CNS invasion in meningiomas

Published in Journal of Neuro-Oncology

Introduction Meningiomas are the most common benign intracranial neoplasms. CNS invasion in meningiomas has been integrated into the 2016 WHO classification of CNS tumors as a stand-alone criterion for atypia. Since then, its prognostic impact has been debated based on contradictory results from retrospective analyses. The aim of the study was to e...

Afatinib and radiotherapy, with or without temozolomide, in patients with newly diagnosed glioblastoma: results of a pha...

Published in Journal of Neuro-Oncology

Background Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Amplification or overexpression of the epidermal growth factor receptor gene, part of the ErbB family, occur in approximately 40% and 60% of patients with GBM, respectively. We present data from a dose-finding study of the ErbB inhibitor afatinib in...

Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of targeted therapi...

Published in Journal of Neuro-Oncology

Abstract The following questions and recommendations are pertinent to the following: Target population These recommendations apply to adults with progressive GBM who have undergone standard primary treatment with surgery and/or chemoradiation. Question 1 In adults with progressive glioblastoma is the use of bevacizumab as monotherapy superior to st...

The centrally restricted diffusion sign on MRI for assessment of radiation necrosis in metastases treated with stereotac...

Published in Journal of Neuro-Oncology

Purpose Differentiation of radiation necrosis from tumor progression in brain metastases treated with stereotactic radiosurgery (SRS) is challenging. For this, we assessed the performance of the centrally restricted diffusion sign. Methods Patients with brain metastases treated with SRS who underwent a subsequent intervention (biopsy/resection) for...