Published in Journal of Neuro-Oncology
IntroductionLabel-free Raman-based imaging techniques create the possibility of bringing chemical and histologic data into the operation room. Relying on the intrinsic biochemical properties of tissues to generate image contrast and optical tissue sectioning, Raman-based imaging methods can be used to detect microscopic tumor infiltration and diagn...
Published in Journal of Neuro-Oncology
IntroductionConvection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system (CNS) that bypasses the blood-brain barrier (BBB) and permits the delivery of high-dose therapeutics to large volumes of interest while limiting associated systemic toxicities. Since its inception, CED has undergone considerable...
Published in Journal of Neuro-Oncology
IntroductionThe use of intraoperative imaging has been a critical tool in the neurosurgeon’s armamentarium and is of particular benefit during tumor surgery. This article summarizes the history of its development, implementation, clinical experience and future directions.MethodsWe reviewed the literature focusing on the development and clinical exp...
Published in Journal of Neuro-Oncology
IntroductionEvidence-based medicine guidelines are increasingly published and sanctioned by organized neurosurgery. However, implementation, interpretation, and use of clinical guidelines may vary substantially on a regional, national and international basis. Survey research can help bridge the gap by providing a snapshot of neurosurgeon attitudes,...
Published in Journal of Neuro-Oncology
The American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Joint Section on Tumors was formed in December of 1984 as the first professional organization devoted to the study and treatment of brain tumors. One year earlier, the Journal of Neuro-Oncology had been established and went on to be sponsored by the Joi...
Published in Journal of Neuro-Oncology
IntroductionMeningioma is the most common primary brain tumor. Most meningiomas are benign; however, a subset of these tumors can be aggressive, presenting with early or multiple tumor recurrences that are refractory to neurosurgical resection and radiotherapy. There is no standard systemic therapy for these patients, and post-surgical management o...
Published in Journal of Neuro-Oncology
IntroductionEvidence-based, clinical practice guidelines in the management of central nervous system tumors (CNS) continue to be developed and updated through the work of the Joint Section on Tumors of the Congress of Neurological Surgeons (CNS) and the American Association of Neurological Surgeons (AANS).MethodsThe guidelines are created using the...
Published in Journal of Neuro-Oncology
IntroductionSince the early use of the endoscopic view for treating simple intrasellar pituitary adenomas, the skull base surgery has experienced an unprecedented revolution elevating the treatment of skull base lesions to the next level in proficiency and excellence of care.MethodsWe have reviewed the preclinical and clinical evidence supporting t...
Published in Journal of Neuro-Oncology
PurposeThe goal of this article is to review the outcomes of insular glioma surgery and discuss strategies to minimize postoperative morbidity.MethodsThe authors reviewed the published literature on low- and high-grade insular gliomas with a focus on glioma biology, insular anatomy, and surgical technique.ResultsMaximal safe resection of insular gl...
Published in Journal of Neuro-Oncology
IntroductionDespite recent advances in treatment for a number of cancers with immune checkpoint blockade (ICB), immunotherapy has had limited efficacy in glioblastoma (GBM). The recent multi-centered CheckMate 143 trial in first time recurrent GBM and the Checkmate 498 trial in newly diagnosed unmethylated GBM showed that antibodies against program...
