Robins, H Ian Zhang, Peixin Gilbert, Mark R Chakravarti, Arnab de Groot, John F Grimm, Sean A Wang, Fen Lieberman, Frank S Krauze, Andra Trotti, Andy M
...
Published in
Journal of neuro-oncology
This study tested the hypothesis that ABT-888 (velparib), a poly (ADP-ribose) polymerase (PARP) inhibitor, can modulate temozolomide (TMZ) resistance in recurrent TMZ refractory glioblastoma patients. The combination regimen (TMZ/ABT-888) was tested using two randomized schedules (5 vs. 21 days), with 6-month progression free survival (PFS6) as the...
Farid, Nikdokht Almeida-Freitas, Daniela B White, Nathan S McDonald, Carrie R Kuperman, Joshua M Almutairi, Abdulrahman A Muller, Karra A VandenBerg, Scott R Kesari, Santosh Dale, Anders M
...
Published in
Journal of neuro-oncology
A subset of patients with high-grade glioma and brain metastases who are treated with bevacizumab develop regions of marked and persistent restricted diffusion that do not reflect recurrent tumor. Here, we quantify the degree of restricted diffusion and the relative cerebral blood volume (rCBV) within these regions of bevacizumab-related imaging ab...
Grewal, Jai Saria, Marlon Garzo Kesari, Santosh
Published in
Journal of neuro-oncology
Leptomeningeal metastasis is a devastating complication of the central nervous system in patients with late-stage solid or hematological cancers. Leptomeningeal metastasis results from the multifocal seeding of the leptomeninges by malignant cancer cells. Although central nervous system metastasis usually presents in patients with widely disseminat...
Rajendran, Ganeshkumar Shanmuganandam, Karthik Bendre, Ameya Muzumdar, Dattatraya Mujumdar, Dattatreya Goel, Abhay Shiras, Anjali
Published in
Journal of Neuro-Oncology
The role of epigenetics and significance of aberrant gene regulation in etiology of cancer is a well-established phenomenon. The hallmark of cancer epigenetics is aberrant DNA methylation consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes (TSGs) by DNA methyltransferases (DNMTs). In mammals, DNA methylation...
Driggers, Lara Zhang, Jian-Gang Newcomb, Elizabeth W Ge, Lisheng Hoa, Neil Jadus, Martin R
Published in
Journal of neuro-oncology
Adults diagnosed with Glioblastoma multiforme (GBM) are frequently faced with a 7% chance of surviving 2 years compared with pediatric patients with GBM who have a 26% survival rate. Our recent screen of possible glioma-associated antigen precursor protein (TAPP) profiles displayed from different types of pediatric brain tumors showed that pediatri...
Hirschberg, Henry Zhang, Michelle J Gach, H Michael Uzal, Francisco A Peng, Qian Sun, Chung-Ho Chighvinadze, David Madsen, Steen J
Published in
Journal of neuro-oncology
Cells infiltrating into normal brain from malignant brain tumors are protected by the blood brain barrier (BBB) which prevents the delivery and limits the effects of anti-tumor agents. We have evaluated the ability of photochemical internalization (PCI) to limit the effects of an agent known to broadly open the BBB to a target region of the brain. ...
Crawford, John R Zaninovic, Alejandra Santi, Mariarita Rushing, Elisabeth J Olsen, Cara H Keating, Robert F Vezina, Gilbert Kadom, Nadja Packer, Roger J
Published in
Journal of neuro-oncology
To determine the relationship between clinical presentation, radiographic features, pathology, and treatment on overall survival of newly diagnosed pediatric primary spinal cord tumors (PSCT). Retrospective analysis of all previously healthy children with newly diagnosed PSCT at a single institution from 1995 to present was performed. Twenty-five p...
Grahn, Amy Y Bankiewicz, Krystof S Dugich-Djordjevic, Millicent Bringas, John R Hadaczek, Piotr Johnson, Greg A Eastman, Simon Luz, Matthias
Published in
Journal of neuro-oncology
Convection-enhanced delivery (CED) of highly stable PEGylated liposomes encapsulating chemotherapeutic drugs has previously been effective against malignant glioma xenografts. We have developed a novel, convectable non-PEGylated liposomal formulation that can be used to encapsulate both the topoisomerase I inhibitor topotecan (topoCED) and paramagn...
Galldiks, N Ullrich, R Schroeter, M Fink, G R Kracht, L W
Published in
Journal of neuro-oncology
MET-PET seems to be useful for monitoring patient-tailored, experimental glioma therapy regimens, especially when patients are treated with a multi-step therapeutic regimen. Monitoring and guidance of those experimental therapy regimens by MET-PET in a larger patient group are needed to confirm its clinical value.
Bian, Liu-Guan Tirakotai, Wuttipong Sun, Qing-Fang Zhao, Wei-Guo Shen, Jian-Kang Luo, Qi-Zhong
Published in
Journal of Neuro-Oncology
The molecular genetic changes in sporadic vestibular schwannomas from Chinese patients were similar to the previous reports. We demonstrate the relationship between tumor behaviors and genetic alteration (including LOH and mutation of NF2 gene). We propose that inactivation of S/M, may be an important step in tumorigenesis of sporadic vestibular sc...
