Olson, Jeffrey J. Ryken, Timothy C.
Published in
Journal of Neuro-Oncology
PurposeThis is an update of the evidence-based guideline for management of newly diagnosed glioblastomas sponsored by the American Association of Neurological Surgeons (AANS) and Congress of Neurological Surgeons (CNS) initially published in 2008. The objective is to update evidence-based management of newly diagnosed glioblastomas over all commonl...
Ziu, Mateo Kim, Betty Y. S. Jiang, Wen Ryken, Timothy Olson, Jeffrey J.
Published in
Journal of Neuro-Oncology
Target populationThese recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.Question 1In adult patients (aged 65 and under) with newly diagnosed glioblastoma, is the addition of radiation therapy (RT) more beneficial than management without RT in improving survival?RecommendationsLevel I: Radiation therapy (RT) is rec...
Redjal, Navid Nahed, Brian V. Dietrich, Jorg Kalkanis, Steven N. Olson, Jeffrey J.
Published in
Journal of Neuro-Oncology
QuestionWhat is the role of temozolomide in the management of adult patients (aged 65 and under) with newly diagnosed glioblastoma?Target populationThese recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.RecommendationLevel I: Concurrent and post-irradiation Temozolomide (TMZ) in combination with radiotherapy and p...
Velázquez Vega, José E. Brat, Daniel J. Ryken, Timothy C. Olson, Jeffrey J.
Published in
Journal of Neuro-Oncology
Target PopulationThese recommendations apply to adult patients with newly diagnosed or suspected glioblastoma (GBM)QuestionFor adult patients with newly diagnosed GBM does testing for Isocitrate Dehydrogenase 1 or 2 (IDH1/2) mutations afford benefit beyond standard histopathology in providing accurate classification and outcome prognostication?Leve...
Domino, Joseph S. Ormond, D. Ryan Germano, Isabelle M. Sami, Mairaj Ryken, Timothy C. Olson, Jeffrey J.
Published in
Journal of Neuro-Oncology
Target populationThese recommendations apply to adults with newly diagnosed or suspected glioblastoma.QuestionWhat is the effect of extent of surgical resection on patient outcome in the initial management of adult patients with suspected newly diagnosed glioblastoma?RecommendationLevel II: Maximal cytoreductive surgery is recommended in adult pati...
Lundy, Paige Domino, Joseph Ryken, Timothy Fouke, Sarah McCracken, David J. Ormond, D. Ryan Olson, Jeffrey J.
Published in
Journal of Neuro-Oncology
Target populationThese recommendations apply to adults with a newly diagnosed lesion with a suspected or histopathologically proven glioblastoma (GBM).QuestionWhat are the optimal imaging techniques to be used in the management of a suspected glioblastoma (GBM), specifically: which imaging sequences are critical for most accurately identifying or d...
Farrell, Christopher Shi, Wenyin Bodman, Alexa Olson, Jeffrey J.
Published in
Journal of Neuro-Oncology
Target populationThese recommendations apply to adult patients with newly diagnosed or suspected glioblastoma.ImagingQuestion What imaging modalities are in development that may be able to provide improvements in diagnosis, and therapeutic guidance for individuals with newly diagnosed glioblastoma?RecommendationLevel III: It is suggested that techn...
Selt, Florian van Tilburg, Cornelis M. Bison, Brigitte Sievers, Philipp Harting, Inga Ecker, Jonas Pajtler, Kristian W. Sahm, Felix Bahr, Annabelle Simon, Michèle
...
Published in
Journal of Neuro-Oncology
Introduction A hallmark of pediatric low-grade glioma (pLGG) is aberrant signaling of the mitogen activated protein kinase (MAPK) pathway. Hence, inhibition of MAPK signaling using small molecule inhibitors such as MEK inhibitors (MEKi) may be a promising strategy. Methods In this multi-center retrospective centrally reviewed study, we analyzed 18 ...
Schneider, Matthias Ilic, Inja Potthoff, Anna-Laura Hamed, Motaz Schäfer, Niklas Velten, Markus Güresir, Erdem Herrlinger, Ulrich Borger, Valeri Vatter, Hartmut
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Published in
Journal of Neuro-Oncology
Introduction Supra-total resection in terms of anterior temporal lobectomy (ATL) has gained growing attention with regard to superior long-term disease control for temporal-located glioblastoma. However, aggressive onco-surgical approaches—geared beyond conventional gross total resections (GTR)—may be associated with peri- and postoperative unfavor...
Schneider, Matthias Potthoff, Anna-Laura Scharnböck, Elisa Heimann, Muriel Schäfer, Niklas Weller, Johannes Schaub, Christina Jacobs, Andreas H Güresir, Erdem Herrlinger, Ulrich
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Published in
Journal of neuro-oncology
Increasing age is a known negative prognostic factor for glioblastoma. However, a multifactorial approach is necessary to achieve optimal neuro-oncological treatment. It remains unclear to what extent frailty, comorbidity burden, and obesity might exert influence on survival in geriatric glioblastoma patients. We have therefore reviewed our institu...
