Pinto, Meri Emili F Chan, Lai Yue Koehbach, Johannes Devi, Seema Gründemann, Carsten Gruber, Christian W Gomes, Mario Bolzani, Vanderlan S Cilli, Eduardo Maffud Craik, David J
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Published in
Journal of natural products
Cyclotides are plant-derived peptides found within five families of flowering plants (Violaceae, Rubiaceae, Fabaceae, Solanaceae, and Poaceae) that have a cyclic backbone and six conserved cysteine residues linked by disulfide bonds. Their presence within the Violaceae species seems ubiquitous, yet not all members of other families produce these ma...
Christy, Mitchell P. Uekusa, Yoshinori Gerwick, Lena Gerwick, William H.
Published in
Journal of Natural Products
Three families of RNA viruses, the Coronaviridae , Flaviviridae , and Filoviridae , collectively have great potential to cause epidemic disease in human populations. The current SARS-CoV-2 ( Coronaviridae ) responsible for the COVID-19 pandemic underscores the lack of effective medications currently available to treat these classes of viral pathoge...
Granica, Sebastian Vahjen, Wilfried Zentek, Jürgen Melzig, Matthias F. Pawłowska, Karolina A. Piwowarski, Jakub P.
Published in
Journal of Natural Products
Lythrum salicaria herb (LSH) was applied in diarrhea therapy since ancient times. Despite empirically referenced therapeutic effects, the bioactivity mechanisms and chemical constituents responsible for pharmacological activity remain not fully resolved. Taking into consideration the historical use of LSH in treatment of diarrhea in humans and farm...
Ganji, Suresh Svensson, Fredric G Unelius, C Rikard
Published in
Journal of natural products
Herein we report the asymmetric syntheses of a number of oxygenated terpenoids that are of importance in the chemical ecology of bark beetles. These are pinocamphones, isopinocamphones, pinocarvones, and 4-thujanols (= sabinene hydrates). The camphones were synthesized from isopinocampheol, the pinocarvones from β-pinene, and the thujanols from sab...
Retzl, Bernhard Hellinger, Roland Muratspahić, Edin Pinto, Meri E F Bolzani, Vanderlan S Gruber, Christian W
Published in
Journal of natural products
Plant peptide protease inhibitors are important molecules in seed storage metabolism and to fight insect pests. Commonly they contain multiple disulfide bonds and are exceptionally stable molecules. In this study, a novel peptide protease inhibitor from beetroot (Beta vulgaris) termed bevuTI-I was isolated, and its primary structure was determined ...
Bús, Csaba Kulmány, Ágnes Kúsz, Norbert Gonda, Tímea Zupkó, István Mándi, Attila Kurtán, Tibor Tóth, Barbara Hohmann, Judit Hunyadi, Attila
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Published in
Journal of Natural Products
Phenanthrenes have become the subject of intensive research during the past decades because of their structural diversity and wide range of pharmacological activities. Earlier studies demonstrated that semisynthetic derivatization of these natural compounds could result in more active agents, and oxidative transformations are particularly promising...
Raspotnig, Günther Anderl, Felix Kunert, Olaf Schaider, Miriam Brückner, Adrian Schubert, Mario Dötterl, Stefan Fuchs, Roman Leis, Hans-Jörg
Published in
Journal of Natural Products
When threatened, the harvestman Egaenus convexus (Opiliones: Phalangiidae) ejects a secretion against offenders. The secretion originates from large prosomal scent glands and is mainly composed of two isomers of 4-hydroxy-5-octyl-4,5-dihydro-3 H -furan-2-one ( 1 ), a β-hydroxy-γ-lactone. The compounds were characterized by GC-MS of their microreact...
Stefkó, Dóra Kúsz, Norbert Barta, Anita Kele, Zoltán Bakacsy, László Szepesi, Ágnes Fazakas, Csilla Wilhelm, Imola Krizbai, István A. Hohmann, Judit
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Published in
Journal of Natural Products
Species in the Juncaceae accumulate different types of secondary metabolites, among them phenanthrenes and 9,10-dihydrophenanthrenes in substantial amounts. These compounds have chemotaxonomic significance and also possess interesting pharmacological activities. The present study has focused on the isolation, structure determination, and pharmacolo...
Zandi, Linda Makungu, Marco Munissi, Joan J. E. Duffy, Sandra Puttreddy, Rakesh von der Heiden, Daniel Rissanen, Kari Avery, Vicky M. Nyandoro, Stephen S. Erdélyi, Máté
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The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4-7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identi...
Atilaw, Yoseph Muiva-Mutisya, Lois Bogaerts, Jonathan Duffy, Sandra Valkonen, Arto Heydenreich, Matthias Avery, Vicky M. Rissanen, Kari Erdélyi, Máté Yenesew, Abiy
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Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic a...