Masi, Marco Di Lecce, Roberta Marsico, Giulia Linaldeddu, Benedetto Teodoro Maddau, Lucia Superchi, Stefano Evidente, Antonio
Published in
Journal of Natural Products
Two new bioactive trisubstituted furanones, named pinofuranoxins A and B ( 1 and 2 ), were isolated from Diplodia sapinea , a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and absolute configurations were assigned by NOESY experiments and compu...
Jacobsson, Erik Peigneur, Steve Andersson, Håkan S. Laborde, Quentin Strand, Malin Tytgat, Jan Göransson, Ulf
Published in
Journal of Natural Products
Peptide toxins find use in medicine, biotechnology, and agriculture. They are exploited as pharmaceutical tools, particularly for the investigation of ion channels. Here, we report the synthesis and activity of a novel family of peptide toxins: the cystine-knotted α nemertides. Following the prototypic α-1 and -2 ( 1 and 2 ), six more nemertides we...
Li, Xia Gao, Jie Li, Miaomiao Cui, Hao Jiang, Wei Tu, Zong-cai Yuan, Tao
Published in
Journal of Natural Products
The ongoing COVID-19 global pandemic caused by SARS-CoV-2 inspires the development of effective inhibitors to block the SARS-CoV-2 spike–ACE2 interaction. A chemical investigation on the fruiting bodies of Phellinus pini led to the isolation of five aromatic cadinane sesquiterpenoids including four new ones, named piniterpenoids A–D ( 1 – 4 ), as w...
Muratspahić, Edin Tomašević, Nataša Nasrollahi-Shirazi, Shahrooz Gattringer, Jasmin Emser, Fabiola Susanna Freissmuth, Michael Gruber, Christian W.
Published in
Journal of Natural Products
Cyclotides are plant-derived disulfide-rich peptides comprising a cyclic cystine knot, which confers remarkable stability against thermal, proteolytic, and chemical degradation. They represent an emerging class of G protein-coupled receptor (GPCR) ligands. In this study, utilizing a screening approach of plant extracts and pharmacological analysis ...
Ekanayake, Dulamini I. Perlatti, Bruno Swenson, Dale C. Põldmaa, Kadri Bills, Gerald F. Gloer, James B.
Published in
Journal of Natural Products
The genus Sphaerostilbella comprises fungi that colonize basidiomata of wood-inhabiting fungi, including important forest pathogens. Studies of fermentation cultures of an isolate (TFC201724) collected on the foothills of Himalayas, and closely related to S. broomeana isolates from Europe, led to the identification of a new cyclic octapeptide along...
Tóth, Gábor Herke, Ibolya Gáti, Tamás Vágvölgyi, Máté Berkecz, Róbert Parfenova, Lyudmila V. Ueno, Minori Yokoi, Taiyo Nakagawa, Yoshiaki Hunyadi, Attila
...
Published in
Journal of Natural Products
Ecdysteroids act as molting hormones in insects and as nonhormonal anabolic agents and adaptogens in mammals. A wide range of ecdysteroid-containing herbal extracts are available worldwide as food supplements. The aim of this work was to study such an extract as a possible industrial source of new bioactive ecdysteroids. A large-scale chromatograph...
Vega-Granados, Karina Medina-O’Donnell, Marta Rivas, Francisco Reyes-Zurita, Fernando J. Martinez, Antonio Alvarez de Cienfuegos, Luis Lupiañez, Jose A. Parra, Andres
Published in
Journal of Natural Products
A set of 12 maslinic acid–coumarin conjugates was synthesized, with 9 being maslinic acid–diamine–coumarin conjugates at the C-28 carboxylic acid group of triterpene acid and the other three being maslinic acid–coumarin conjugates at C-2/C-3 and/or C-28 of the triterpene skeleton. The cytotoxic effects of these 12 triterpene conjugates were evaluat...
Sa-ngiamsuntorn, Khanit Suksatu, Ampa Pewkliang, Yongyut Thongsri, Piyanoot Kanjanasirirat, Phongthon Manopwisedjaroen, Suwimon Charoensutthivarakul, Sitthivut Wongtrakoongate, Patompon Pitiporn, Supaporn Chaopreecha, Jarinya
...
Published in
Journal of Natural Products
The coronaviruses disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2) has become a major health problem, affecting more than 50 million people with over one million deaths globally. Effective antivirals are still lacking. Here, we optimized a high-content imaging platform and the plaque assay for viral output study using the legitima...
van Zadelhoff, Annemiek de Bruijn, Wouter J. C. Fang, Zhongxiang Gaquerel, Emmanuel Ishihara, Atsushi Werck-Reichhart, Danièle Zhang, Pangzhen Zhou, Guangxiong Franssen, Maurice C. R. Vincken, Jean-Paul
...
Published in
Journal of Natural Products
Phenylalkenoic acid amides, often referred to as phenol amides or hydroxycinnamic acid amides, are bioactive phytochemicals, whose bioactivity can be enhanced by coupling to form dimers or oligomers. Phenylalkenoic acid amides consist of a (hydroxy)cinnamic acid derivative (i.e., the phenylalkenoic acid subunit) linked to an amine-containing compou...
Liu, Miaomiao Han, Jianying Feng, Yunjiang Guymer, Gordon Forster, Paul I. Quinn, Ronald J.
Published in
Journal of Natural Products
Four new alkaloids, ( R )-nomimantharine trifluoroacetate ( 2 ), 12-demethylphaeantharine trifluoroacetate ( 3 ), nominanthranal trifluoroacetate ( 4 ), and the enolic form of 1-hydroxy-6,7-dimethoxy-2-methylisoquinoline trifluoroacetate ( 5 ), together with the known dimeric alkaloid phaeantharine trifluoroacetate ( 1 ), have been isolated from th...
