Published in Journal of Natural Products
Two new biflavanones ( 1 and 2 ), three new bichalconoids ( 3 – 5 ), and 11 known flavonoid analogues ( 6 – 16 ) were isolated from the stem bark extract (CH3OH–CH2Cl2, 7:3, v/v) of Ochna holstii . The structures of the isolated metabolites were elucidated by NMR spectroscopic and mass spectrometric analyses. The crude extract and the isolated meta...
Published in Journal of Natural Products
Despite an excellent track record, microbial drug discovery suffers from high rates of rediscovery. Better workflows for the rapid investigation of complex extracts are needed to increase throughput and to allow early prioritization of samples. In addition, systematic characterization of poorly explored strains is seldomly performed. Here, we repor...
Published in Journal of Natural Products
Lactylates are an important group of molecules in the food and cosmetic industries. A series of natural halogenated 1-lactylates, chlorosphaerolactylates ( 1 – 4 ), were recently reported from Sphaerospermopsis sp. LEGE 00249. Here, we identify the cly biosynthetic gene cluster, containing all the necessary functionalities for the biosynthesis of t...
Published in Journal of natural products
Cyclotides are plant-derived peptides found within five families of flowering plants (Violaceae, Rubiaceae, Fabaceae, Solanaceae, and Poaceae) that have a cyclic backbone and six conserved cysteine residues linked by disulfide bonds. Their presence within the Violaceae species seems ubiquitous, yet not all members of other families produce these ma...
Published in Journal of Natural Products
Three families of RNA viruses, the Coronaviridae , Flaviviridae , and Filoviridae , collectively have great potential to cause epidemic disease in human populations. The current SARS-CoV-2 ( Coronaviridae ) responsible for the COVID-19 pandemic underscores the lack of effective medications currently available to treat these classes of viral pathoge...
Published in Journal of Natural Products
Lythrum salicaria herb (LSH) was applied in diarrhea therapy since ancient times. Despite empirically referenced therapeutic effects, the bioactivity mechanisms and chemical constituents responsible for pharmacological activity remain not fully resolved. Taking into consideration the historical use of LSH in treatment of diarrhea in humans and farm...
Published in Journal of natural products
Herein we report the asymmetric syntheses of a number of oxygenated terpenoids that are of importance in the chemical ecology of bark beetles. These are pinocamphones, isopinocamphones, pinocarvones, and 4-thujanols (= sabinene hydrates). The camphones were synthesized from isopinocampheol, the pinocarvones from β-pinene, and the thujanols from sab...
Published in Journal of natural products
Plant peptide protease inhibitors are important molecules in seed storage metabolism and to fight insect pests. Commonly they contain multiple disulfide bonds and are exceptionally stable molecules. In this study, a novel peptide protease inhibitor from beetroot (Beta vulgaris) termed bevuTI-I was isolated, and its primary structure was determined ...
Published in Journal of Natural Products
Phenanthrenes have become the subject of intensive research during the past decades because of their structural diversity and wide range of pharmacological activities. Earlier studies demonstrated that semisynthetic derivatization of these natural compounds could result in more active agents, and oxidative transformations are particularly promising...
Published in Journal of Natural Products
When threatened, the harvestman Egaenus convexus (Opiliones: Phalangiidae) ejects a secretion against offenders. The secretion originates from large prosomal scent glands and is mainly composed of two isomers of 4-hydroxy-5-octyl-4,5-dihydro-3 H -furan-2-one ( 1 ), a β-hydroxy-γ-lactone. The compounds were characterized by GC-MS of their microreact...
