Zhang, Wenfeng Chen, Ziwei Qiao, Shuaihua Chen, Siyuan Zheng, Hongyan Wei, Xuan Li, Qiaoling Xu, Biao Huang, Wei
Published in
Journal of Nanobiotechnology
BackgroundDilated cardiomyopathy (DCM) is one of the common causes of heart failure. Myocardial injury triggers an inflammatory response and recruits immune cells into the heart. High expression of Krüppel-like factor 2 (KLF2) in endothelial cells (ECs) potentially exerts an anti-inflammatory effect. However, the role of extracellular vesicles (EVs...
Joseph, John Bruno, Vito Domenico Sulaiman, Nadiah Ward, Alexander Johnson, Thomas W. Baby, Helna Mary Nair, Shantikumar V. Menon, Deepthy George, Sarah Jane Ascione, Raimondo
...
Published in
Journal of Nanobiotechnology
Globally, millions of patients are affected by myocardial infarction or lower limb gangrene/amputation due to atherosclerosis. Available surgical treatment based on vein and synthetic grafts provides sub-optimal benefits. We engineered a highly flexible and mechanically robust nanotextile-based vascular graft (NanoGraft) by interweaving nanofibrous...
Campos-Silva, Carmen Cáceres-Martell, Yaiza Sánchez-Herrero, Estela Sandúa, Amaia Beneitez-Martínez, Alexandra González, Álvaro Provencio, Mariano Romero, Atocha Jara-Acevedo, Ricardo Yáñez-Mó, María
...
Published in
Journal of Nanobiotechnology
BackgroundExtracellular vesicles (EVs), released by most cell types, provide an excellent source of biomarkers in biological fluids. However, in order to perform validation studies and screenings of patient samples, it is still necessary to develop general techniques permitting rapid handling of small amounts of biological samples from large number...
Liu, Haikun Pietersz, Geoffrey Peter, Karlheinz Wang, Xiaowei
Published in
Journal of Nanobiotechnology
Atherosclerosis and atherothrombosis, the major contributors to cardiovascular diseases (CVDs), represent the leading cause of death worldwide. Current pharmacological therapies have been associated with side effects or are insufficient at halting atherosclerotic progression effectively. Pioneering work harnessing the passive diffusion or endocytos...
Mohammadi, Somayeh Salimi, Abdollah Hoseinkhani, Zohreh Ghasemi, Foad Mansouri, Kamran
Published in
Journal of Nanobiotechnology
BackgroundMicroRNAs have short sequences of 20 ~ 25-nucleotides which are similar among family members and play crucial regulatory roles in numerous biological processes, such as in cell development, metabolism, proliferation, differentiation, and apoptosis.ResultsWe reported a strategy for the construction of a dual-emission fluorescent sensor usi...
Kulkarni, Tanmay Mukhopadhyay, Debabrata Bhattacharya, Santanu
Published in
Journal of Nanobiotechnology
BackgroundEfficacy of targeted drug delivery using nanoparticles relies on several factors including the uptake mechanisms such as phagocytosis, macropinocytosis, micropinocytosis and receptor mediated endocytosis. These mechanisms have been studied with respect to the alteration in signaling mechanisms, cellular morphology, and linear nanomechanic...
Tong, Ting Deng, Shuangfei Zhang, Xiaotong Fang, Liurong Liang, Jiangong Xiao, Shaobo
Published in
Journal of Nanobiotechnology
BackgroundThe infection and spread of porcine reproductive and respiratory syndrome virus (PRRSV) pose a serious threat to the global pig industry, and inhibiting the viral infection process is a promising treatment strategy. Nanomaterials can interact with viruses and have attracted much attention due to their large specific surface area and uniqu...
Wang, Wei Xiong, Yinze Zhao, Renliang Li, Xiang Jia, Weitao
Published in
Journal of Nanobiotechnology
BackgroundFemoral stem of titanium alloy has been widely used for hip arthroplasty with considerable efficacy; however, the application of this implant in patients with osteoporosis is limited due to excessive bone resorption. Macrophages participate in the regulation of inflammatory response and have been a topic of increasing research interest in...
Wang, Yandong Gao, Fucheng Li, Xiaofeng Niu, Guiming Yang, Yufei Li, Hui Jiang, Yanyan
Published in
Journal of Nanobiotechnology
Chemodynamic therapy (CDT) based on Fenton or Fenton-like reactions is an emerging cancer treatment that can both effectively fight cancer and reduce side effects on normal cells and tissues, and it has made important progress in cancer treatment. The catalytic efficiency of Fenton nanocatalysts(F-NCs) directly determines the anticancer effect of C...
Zhuang, Shangwen Xiang, Huijing Chen, Yixin Wang, Lulu Chen, Yu Zhang, Jun
Published in
Journal of Nanobiotechnology
The engineered nanoformulation that can be activated by intracellular tumor microenvironment, including acidic pH, overexpressed H2O2, and high concentration of glutathione (GSH), features high efficacy to eradicate tumor cells with the intrinsic specificity and therapeutic biosafety. However, the relatively slow reaction rate of traditional Fe2+-m...
