Fu, Shengyang Zhao, Shu Chen, Huili Yang, Weitao Xia, Xiaohuan Xu, Xiaonan Liang, Zhanping Feng, Xuanran Wang, Zhuo Ai, Pu
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Published in
Journal of Nanobiotechnology
Traumatic brain injury (TBI) is a cause of disability and death worldwide, but there are currently no specific treatments for this condition. Release of excess reactive oxygen species (ROS) in the injured brain leads to a series of pathological changes; thus, eliminating ROS could be a potential therapeutic strategy. Herein, we synthesized insulin-...
Wang, Fengling Xie, Dandan Lai, Wenjing Zhou, Min Wang, Jie Xu, Rufu Huang, Jingbing Zhang, Rong Li, Guobing
Published in
Journal of Nanobiotechnology
Deep tumor cells (cells in the center of solid tumors) play a crucial role in drug tolerance, metastasis, recurrence and microenvironment immune suppression. However, their deep location endows them with an untouched abdomen and makes them refractory to current treatments. Herein, we exploited the characteristic of higher autophagy in deep tumor ce...
Zou, Qin Zhang, Mei Yuan, Rong Wang, Yifei Gong, Zhengyin Shi, Rui Li, Yujing Fei, Kaixin Luo, Chenggang Xiong, Ying
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Published in
Journal of Nanobiotechnology
Skin thickness is closely related to the appearance of human skin, such as sagging and wrinkling, which primarily depends on the level of collagen I synthesized by dermal fibroblasts (DFs). Small extracellular vesicles (SEVs), especially those derived from human DFs (HDFs), are crucial orchestrators in shaping physiological and pathological develop...
Xu, Xiao Mao, Huafen Wu, Yunchao Liu, Suwan Liu, Jingjin Li, Qianzhe Yang, Mengyu Zhu, Jinqian Zou, Shengqiang Du, Fengyi
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Published in
Journal of Nanobiotechnology
Background Phototherapy-triggered immunogenic cell death (ICD) rarely elicits a robust antitumour immune response, partially due to low antigen exposure and inefficient antigen presentation. To address these issues, we developed novel methylene blue-loaded ovalbumin/polypyrrole nanoparticles ([email protected]/PPY NPs) via oxidative polymerization and π–π sta...
Lee, Zui-Harng Lee, Meng-Feng Chen, Jung-Huang Tsou, Min-Hsuan Wu, Zhi-Yuan Lee, Cheng-Zhang Huang, Yu-Ya Lin, Showe-Mei Lin, Hsiu-Mei
Published in
Journal of Nanobiotechnology
In this study, we used the nanoparticle delivery system to reduce the side effect of conventional cancer treatment- radiation therapy and chemotherapy. We used rice husk silicon source mesoporous silica nanoparticle doped in Eu3+ and Gd3+ as the carrier in the delivery system and to enable fluorescence and MRI dual-imaging functions for follow-up t...
Huang, Xing Xu, Liusheng Qian, Hui Wang, Xinghuan Tao, Zhimin
Published in
Journal of Nanobiotechnology
The biosynthesis of polymalic acid (PMLA) and its biotechnical high-grade production from microorganisms compared with the chemical synthesis of PMLA The physicochemical and biological characteristics of PMLA and its derivatives How PMLA’s general chemical characteristics can be used to generate various macromolecular compounds for pharmaceutical d...
Bergstrand, Jan Miao, Xinyan Srambickal, Chinmaya Venugopal Auer, Gert Widengren, Jerker
Published in
Journal of Nanobiotechnology
Background Increasing evidence suggests that platelets play a central role in cancer progression, with altered storage and selective release from platelets of specific tumor-promoting proteins as a major mechanism. Fluorescence-based super-resolution microscopy (SRM) can resolve nanoscale spatial distribution patterns of such proteins, and how they...
Gao, Shaoying Chen, Tao Wang, Zhen Ji, Ping Xu, Lin Cui, Wenguo Wang, Ying
Published in
Journal of Nanobiotechnology
Diabetic wound is the leading cause of non-traumatic amputations in which oxidative stress and chronic inflammation are main factors affecting wound healing. Although mesenchymal stem cells (MSCs) as living materials can promote skin regeneration, they are still vulnerable to oxidative stress which limits their clinical applications. Herein, we hav...
Bo, Yunyao Yang, Lijun Liu, Baiting Tian, Guiping Li, Chenxi Zhang, Lin Yan, Yuan
Published in
Journal of Nanobiotechnology
Background The use of keratinocytes derived from induced pluripotent stem cells (iPSCs-KCs) may represent a novel cell therapy strategy for burn treatment. There is growing evidence that extracellular vesicles, including exosomes, are primary mediators of the benefits of stem cell therapy. Herein, we thus explored the effects of exosomes produced b...
Chen, Lei Zhang, Jinghui Xu, Lihua Zhu, Luchao Jing, Jinpeng Feng, Yushuo Wang, Zongzhang Liu, Peifei Sun, Wenjing Liu, Xiangmei
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Published in
Journal of Nanobiotechnology
Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. However, the secondary excitation of these high-Z elements-doped nanosensitizers still imply intrinsic defects of low efficiency. Herein, we design...