de la Fuente-Herreruela, Diego Monnappa, Ajay K. Muñoz-Úbeda, Mónica Morallón-Piña, Aarón Enciso, Eduardo Sánchez, Luis Giusti, Fabrice Natale, Paolo López-Montero, Iván
Published in
Journal of Nanobiotechnology
BackgroundThe design of efficient drug delivery vectors requires versatile formulations able to simultaneously direct a multitude of molecular targets and to bypass the endosomal recycling pathway of cells. Liposomal-based vectors need the decoration of the lipid surface with specific peptides to fulfill the functional requirements. The unspecific ...
Córdoba-Jover, Bernat Arce-Cerezo, Altamira Ribera, Jordi Pauta, Montse Oró, Denise Casals, Gregori Fernández-Varo, Guillermo Casals, Eudald Puntes, Victor Jiménez, Wladimiro
...
Published in
Journal of Nanobiotechnology
Background and aimsCerium oxide nanoparticles are effective scavengers of reactive oxygen species and have been proposed as a treatment for oxidative stress-related diseases. Consequently, we aimed to investigate the effect of these nanoparticles on hepatic regeneration after liver injury by partial hepatectomy and acetaminophen overdose.MethodsAll...
Vogel, Viola
Published in
Journal of Nanobiotechnology
As we are approaching 20 years after the US National Nanotechnology Initiative has been announced, whereby most of that funding was spend to engineer, characterize and bring nanoparticles and nanosensors to the market, it is timely to assess the progress made. Beyond revolutionizing nonmedical applications, including construction materials and the ...
Zhang, Sipei Guo, Nan Wan, Guoyun Zhang, Tao Li, Chunyu Wang, Yongfei Wang, Yinsong Liu, Yuanyuan
Published in
Journal of Nanobiotechnology
BackgroundMultidrug resistance (MDR) generally leads to breast cancer treatment failure. The most common mechanism of MDR is the overexpression of ATP-binding cassette (ABC) efflux transporters such as P-glycoprotein (P-gp) that reduce the intracellular accumulation of various chemotherapeutic agents. Celecoxib (CXB), a selective COX-2 inhibitor, c...
Plaza-GA, Ismael Manzaneda-González, Vanesa Kisovec, Matic Almendro-Vedia, Víctor Muñoz-Úbeda, Mónica Anderluh, Gregor Guerrero-Martínez, Andrés Natale, Paolo López Montero, Iván
Published in
Journal of Nanobiotechnology
BackgroundA major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In nature, the bacterial pathogen Listeria monocytogenes has developed a strategy to secrete Listeriolysin O (LLO) toxin as a tool to ...
Yuan, Shen-Jun Xu, Yong-Hong Wang, Chao An, Hui-Chao Xu, Hua-Zhen Li, Ke Komatsu, Naoki Zhao, Li Chen, Xiao
Published in
Journal of Nanobiotechnology
BackgroundTriple negative breast cancer (TNBC) has the poorest prognosis of all breast cancer subtypes and is one of the most fatal diseases for women. Combining cytotoxic chemotherapy with immunotherapy has shown great promise for TNBC treatment. However, chemotherapy often leads to the development of chemoresistance and severe systemic toxicity c...
Villar-Alvarez, E. Cambón, A. Pardo, A. Arellano, L. Marcos, A. V. Pelaz, B. del Pino, P. Bouzas Mosquera, A. Mosquera, V. X. Almodlej, A.
...
Published in
Journal of Nanobiotechnology
BackgroundImproving the water solubility of hydrophobic drugs, increasing their accumulation in tumor tissue and allowing their simultaneous action by different pathways are essential issues for a successful chemotherapeutic activity in cancer treatment. Considering potential clinical application in the future, it will be promising to achieve such ...
Depciuch, J. Stec, M. Klebowski, B. Baran, J. Parlinska-Wojtan, M.
Published in
Journal of Nanobiotechnology
BackgroundNew nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosensitizers in PTT.ResultsLight microscopy images of two colon cancer cell lines (SW480, SW620) showed, that the laser irradiation com...
Wang, Yanshu Liu, Huanhuan Yao, Defan Li, Jinning Yang, Shuyan Zhang, Caiyuan Chen, Weibo Wang, Dengbin
Published in
Journal of Nanobiotechnology
PurposeTo develop a novel fluorine-18 (18F)-labeled arginine–glycine–aspartic acid (RGD)-coupled ultra-small iron oxide nanoparticle (USPIO) (hereafter, referred to as [email protected]) and conduct an in-depth investigation to monitor the anti-angiogenic therapeutic effects by using a novel dual-modality PET/MRI probe.MethodsThe RGD peptide and 18F we...
Zhang, Yongxin Fu, Hao Liu, De-E An, Jinxia Gao, Hui
Published in
Journal of Nanobiotechnology
BackgroundEfficient and highly controllable antibacterial effect, as well as good biocompatibility are required for antibacterial materials to overcome multi-drug resistance in bacteria. Herein, nano graphene oxide (NGO)-based near-infrared (NIR) photothermal antibacterial materials was schemed to complex with biocompatible bovine serum albumin (BS...
