Published in Neuropsychobiology
Background: The results of studies examining the response to experimental pain during the menstrual cycle are conflicting because of differences in the definitions of the menstrual period, outcome measures and types of experimental pain stimulation. So far, there have been only a few studies correlating experimental pain with the levels of gonadal ...
Published in Journal of Molecular Biology
The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a major outbreak of respiratory disease centered on Hubei province, China. It is now a global pandemic and is a major public health concern. Taxonomically, SARS-CoV-2 was shown to be a Betacoronavirus (lineage B) closely related to SARS-CoV and SARS-related bat coronaviru...
Published in Journal of Molecular Biology
• mAb397 from an RTS,S trial binds NANP repeats of malaria circumsporozoite protein. • Protective mAb397 is encoded by the VH3-15 gene that is rare for NANP antibodies. • Anti-NANP mAbs bind type I β-turns in three modes using germline-encoded Trp residues. • The Trp of mAb397 interacts with Asn instead of Pro in the NPNA type I β-turn. • Diversity...
Published in Journal of Molecular Biology
• While the DNA Double Strand break (DSB)-induced chromatin landscape starts to be deciphered, our knowledge of the chromatin conformation around DSB is still very poor. • The initial chromosome conformation may contribute to γH2AX spreading and hence to the activation of the DNA Damage Response. • Chromosome architecture likely changes in cis to a...
Published in Journal of Molecular Biology
• Amyloid proteins α-synuclein and tauK18 can be ubiquitinated by UBE2W. • N-terminal ubiquitin modification on amyloid proteins delays aggregation. • Proteasomes can remove N-terminal ubiquitin-modified oligomers. • Proteasomes remove oligomers primarily by enabling their dissociation.
Published in Journal of Molecular Biology
Published in Journal of molecular biology
The endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and signal transduction. It is subject to complex, dynamic sculpting of morphology and composition. Degradation of ER content has an important role to play here. Indeed, a major emerging player in ER turnover is ER-phagy, the degradation of ER fragments by selective au...
Published in Journal of molecular biology
Autophagy, self-eating, is a pivotal catabolic mechanism that ensures homeostasis and survival of the cell in the face of stressors as different as starvation, infection, or protein misfolding. The importance of the research in this field was recognized by the general public after the Nobel Prize for Physiology or Medicine was awarded in 2016 to Yo...
Published in Journal of Molecular Biology
• Selective autophagy mediates cellular homeostasis by delivering harmful material into lysosomes for degradation. • The activity of the ULK1/Atg1 kinase complex is required to initiate the formation of autophagosomes, which capture the cargo material. • In selective autophagy receptors act upstream of the autophagy machinery by recruiting the Atg1...
Published in Journal of Molecular Biology
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