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Published in Journal of Intensive Care
Comment on Early versus delayed mobilization for in-hospital mortality and health-related quality of life among critical...
Published in Journal of Intensive Care
Critical comment on the review by Okada et al. on the effect of early versus delayed mobilization because of their definition of early mobilization as mobilization within a week of ICU admission in contrast to current evidence.
Thoracic fluid content: a novel parameter for predicting failed weaning from mechanical ventilation
Published in Journal of Intensive Care
BackgroundWeaning of patients from the mechanical ventilation remains one of the critical decisions in intensive care unit. This study aimed to evaluate the accuracy of thoracic fluid content (TFC) as a predictor of weaning outcome.MethodsAn observational cohort study included 64 critically ill surgical patients who were eligible for extubation. Be...
Variables predicting weaning outcome in prolonged mechanically ventilated tracheotomized patients: a retrospective study...
Published in Journal of Intensive Care
BackgroundSeveral studies have assessed predictors of weaning and extubation outcome in short-term mechanically ventilated patients, but there are only few studies on predictors of weaning from prolonged mechanical ventilation.MethodsRetrospective, single-center, observational study at a specialized national weaning center in Germany. Patients’ med...
A question is “what are the optimal targets for anticoagulant therapies?”
...Published in Journal of Intensive Care
A high mortality rate is found among septic patients with disseminated intravascular coagulation (DIC). Anticoagulants have been used for treating septic DIC especially in Japanese clinical settings; however, their effectiveness is quite controversial across studies. According to several randomized controlled trials and meta-analyses, antithrombin ...
Should we treat sepsis-induced DIC with anticoagulants?
Published in Journal of Intensive Care
BackgroundDisseminated intravascular coagulation (DIC) is a common complication in sepsis because of crosstalk between the immune system and the coagulation system. Several anticoagulant agents have been tested in an attempt to improve the survival of patients with sepsis and sepsis-induced DIC. Here, we discuss the rationale against using anticoag...
Validity of an under-mattress sensor for objective sleep measurement in critically ill patients: a prospective observati...
Published in Journal of Intensive Care
BackgroundConsidering the adverse effects of sleep disturbance in critical care settings, accurate assessment could aid therapy; however, methodological inadequacies mean that no viable option is currently available. Research in healthy population has recently shown that a non-wearable sleep measurement device placed under the mattress of the bed c...
Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis
Published in Journal of Intensive Care
BackgroundOur recent meta-analysis indicated that vitamin C may shorten the length of ICU stay and the duration of mechanical ventilation. Here we analyze modification of the vitamin C effect on ventilation time, by the control group ventilation time (which we used as a proxy for severity of disease in the patients of each trial).MethodsWe searched...
Hemodynamic effects of intravenous paracetamol in critically ill children with septic shock on inotropic support
Published in Journal of Intensive Care
BackgroundTreatment with intravenous paracetamol may impair hemodynamics in critically ill adults. Few data are available in children. The aim of this study was to investigate the frequency, extent, and risk factors of hypotension following intravenous paracetamol administration in children with septic shock on inotropic support.MethodsWe retrospec...
Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance
Published in Journal of Intensive Care
Along with the recent spread of multidrug-resistant bacteria, outbreaks of extended-spectrum β-lactamase (ESBL) and carbapenemase-producing bacteria present a serious challenge to clinicians. β-lactam antibiotics are the most frequently used antibacterial agents and ESBLs, and carbapenemases confer resistance not only to carbapenem antibiotics but ...
