Balachandran, Yadu Caldwell, Sarah Aulakh, Gurpreet Kaur Singh, Baljit
Published in
Journal of Innate Immunity
Toll-like receptors are innate immune receptors that play a critical role in pathogen-associated molecular pattern recognition. TLR10 was recently identified and very limited data are available on its expression, mechanisms that regulate its expression, and its role in primary immune cells. To study the expression pattern of TLR10 in primary immune...
Zhu, Wenliang Huang, Xiaopei Qiu, Shi Feng, Lingxiao Wu, Yue Shao, Huanzhang
Published in
Journal of Innate Immunity
This study intends to investigate the effects of miR-142-5p encapsulated by serum-derived extracellular vesicles (EVs) on septic acute lung injury (ALI) following remote ischemic preconditioning (RIPC) through a PTEN-involved mechanism. ALI was induced in rats by lipopolysaccharide (LPS) injection, 24 h before which RIPC was performed via the left ...
Renieris, Georgios Karakike, Eleni Gkavogianni, Theologia Droggiti, Dionysia-Eirini Stylianakis, Emmanouil Andriopoulou, Theano Spanou, Victoria-Marina Kafousopoulos, Dionyssios Netea, Mihai G. Eugen-Olsen, Jesper
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Published in
Journal of Innate Immunity
Acute respiratory distress syndrome (ARDS) in COVID-19 has been associated with catastrophic inflammation. We present measurements in humans and a new animal model implicating a role in danger-associated molecular patterns. Calprotectin (S100A8/A9) and high-mobility group box 1 (HMGB1) were measured in patients without/with ARDS, and admission calp...
Ahmed, Shabbir Sajjadian, Seyedeh Minoo Kim, Yonggyun
Published in
Journal of Innate Immunity
Several mosquitoes transmit human pathogens by blood feeding, with the gut being the main entrance for the pathogens. Thus, the gut epithelium defends the pathogens by eliciting potent immune responses. However, it was unclear how the mosquito gut discriminates pathogens among various microflora in the lumen. This study proposed a hypothesis that a...
Zheng, Xu Wang, Ke Pan, Lang Hao, Wenjing Xue, Yaoyao Bacsi, Attila Vlahopoulos, Spiros A. Radak, Zsolt Hazra, Tapas K. Brasier, Allan R.
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Published in
Journal of Innate Immunity
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these processes are not fully understood. We hypothesized that expressions of IIR genes are controlled by the ROS-gen...
Svensson, Maria C. Svensson, Maja Nodin, Björn Borg, David Hedner, Charlotta Hjalmarsson, Claes Leandersson, Karin Jirström, Karin
Published in
Journal of Innate Immunity
Tumor-associated macrophages (TAMs) have emerged as key players in tumor immunology but demonstrate a continuum of functional states being either tumor suppressive or promoting. Moreover, chemotherapeutic agents have been shown to alter the tumor microenvironment. Perioperative chemotherapy is a standard treatment option for resectable esophageal a...
Stange, Eva-Lena Rademacher, Franziska Drerup, Katharina Antonia Heinemann, Nina Möbus, Lena Gläser, Regine Harder, Jürgen
Published in
Journal of Innate Immunity
Staphylococcus aureus is an important pathogen causing various infections, including – as most frequently isolated bacterium – cutaneous infections. Keratinocytes as the first barrier cells of the skin respond to S. aureus by the release of defense molecules such as cytokines and antimicrobial peptides. Although several pattern recognition receptor...
Liu, Zhen-Mi Wang, Xi Li, Chen-Xi Liu, Xue-Yan Guo, Xiao-Jing Li, Yang Chen, You-Lian Ye, Hong-Xing Chen, Huai-Sheng
Published in
Journal of Innate Immunity
As a serious and elusive syndrome caused by infection, sepsis causes a high rate of mortality around the world. Our investigation aims at exploring the role and possible mechanism of specificity protein-1 (SP1) in the development of sepsis. A mouse model of sepsis was established by cecal ligation perforation, and a cellular model was stimulated by...
Lorenz, Georg Ribeiro, Andrea von Rauchhaupt, Ekatharina Würf, Vivian Schmaderer, Christoph Cohen, Clemens D. Vohra, Twinkle Anders, Hans-Joachim Lindenmeyer, Maja Lech, Maciej
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Published in
Journal of Innate Immunity
Growth and differentiation factor 15 (GDF15), a divergent member of the transforming growth factor-β superfamily, has been associated with acute and chronic inflammatory conditions including autoimmune disease, i.e., type I diabetes and rheumatoid arthritis. Still, its role in systemic autoimmune disease remains elusive. Thus, we studied GDF15-defi...
Nirujogi, Teja Srinivas Kotha, Sainath R. Chung, Sangwoon Reader, Brenda F. Yenigalla, Anita Zhang, Liwen Shapiro, John P. Wisler, Jon Christman, John W. Maddipati, Krishnarao
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Published in
Journal of Innate Immunity
Emerging data support the pivotal role of extracellular vesicles (EVs) in normal cellular physiology and disease conditions. However, despite their abundance, there is much less information about the lipid mediators carried in EVs, especially in the context of acute lung injury (ALI). Our data demonstrate that C57BL/6 mice subjected to intranasal E...