Serious, Severe, Sepsis
Published in Journal of Innate Immunity
Group 2 Innate Lymphoid Cells in Human Respiratory Disorders
Published in Journal of Innate Immunity
Recent studies using animal models have generated profound insight into the functions of various subsets of innate lymphoid cells (ILCs). The group 2 ILC subset (ILC2) has been implicated in tissue homeostasis, defense responses against parasites, tissue repair, and immunopathology associated with type-2 immunity. In addition, progress has also bee...
The Role of Toll-Like Receptors in the Production of Cytokines by Human Lung Macrophages
Published in Journal of Innate Immunity
Background: The Toll-like receptor (TLR) family is involved in the recognition of and response to microbial infections. These receptors are expressed in leukocytes. TLR stimulation induces the production of proinflammatory cytokines and chemokines. Given that human lung macrophages (LMs) constitute the first line of defense against inhaled pathogen...
Innate Immunity of the Lung
Published in Journal of Innate Immunity
Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases
Published in Journal of Innate Immunity
Lung innate immunity is the first line of defence against inhaled allergens, pathogens and environmental pollutants. Cellular metabolism plays a key role in innate immunity. Catabolic pathways, including glycolysis and fatty acid oxidation (FAO), are interconnected with biosynthetic and redox pathways. Innate immune cell activation and differentiat...
Innate Immune Evasion by Human Respiratory RNA Viruses
Published in Journal of Innate Immunity
The impact of respiratory virus infections on the health of children and adults can be very significant. Yet, in contrast to most other childhood infections as well as other viral and bacterial diseases, prophylactic vaccines or effective antiviral treatments against viral respiratory infections are either still not available, or provide only limit...
Tackling the Pros and Cons of Inflammation
Published in Journal of Innate Immunity
Long Noncoding RNA Linc00632 Inhibits Interleukin-13-Induced Inflammatory Cytokine and Mucus Production in Nasal Epithel...
Published in Journal of Innate Immunity
Allergic rhinitis (AR) is an allergic disease characterized as (immunoglobulin E)-mediated type I hypersensitivity disorder. The interleukin-13 (IL-13) signaling pathway has been implicated in the pathogenesis of AR. In the present study, we investigated the regulatory role and mechanism of long noncoding RNA Linc00632 in IL-13-induced inflammatory...
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Inv...
Published in Journal of Innate Immunity
Streptococcus pneumoniae and Neisseria meningitidis are pathogens that frequently colonize the nasopharynx in an asymptomatic manner but are also a cause of invasive bacterial infections mainly in young children. The complement system plays a crucial role in humoral immunity, complementing the ability of antibodies to clear microbes, thereby protec...
The Estrogen-Induced miR-19 Downregulates Secretory Leucoprotease Inhibitor Expression in Monocytes
Published in Journal of Innate Immunity
Compared to females, males are more susceptible to acute viral and other respiratory tract infections that display greater severity and higher mortality. In contrast, females tend to fare worse with chronic inflammatory diseases. Circulating 17β-estradiol (E2) is a female-specific factor that may influence the progression of human lung diseases. He...
