Nomoto, Hidetoshi Yamamoto, Kei Yamada, Gen Suzuki, Michiyo Kinoshita, Noriko Takasaki, Jin Moriya, Ataru Maeda, Kenji Kimura, Motoi Ohmagari, Norio
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Published in
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
The automated quantitative antigen test (QAT), which detects severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is suitable for mass screening. However, its diagnostic capability differentiated by time from onset and potential contribution to infectivity assessment have not been fully investigated. A retrospective, observational study us...
Miyamoto, Kyohei Koizumi, Yusuke Tamura, Shinobu Nakashima, Tsuyoshi Kobai, Kaori Tanaka, Rikako Shibata, Mami Shima, Nozomu Nemoto, Shigeki Fukumoto, Nobu
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Published in
Journal of Infection and Chemotherapy
Multisystem inflammatory syndrome in adults (MIS-A) is a rare and emerging syndrome after coronavirus disease 2019 (COVID-19). To the best of our knowledge, Japanese cases of MIS-A are rarely reported. Here, we describe a case of MIS-A in a 44-year-old Japanese woman presenting with multiorgan dysfunction (i.e., cardiovascular and mucocutaneous inv...
Itoh, Kazuhiro Sakamaki, Ippei Hirota, Tomoya Iwasaki, Hiromichi
Published in
Journal of Infection and Chemotherapy
The aim of this study was to investigate the efficacy and safety of minocycline (MIN) and favipiravir combination therapy in patients with coronavirus disease 2019 (COVID-19) admitted to our hospital in Fukui Prefecture, Japan, in March and April of 2020. In this retrospective study, a favipiravir monotherapy group (Control group, n = 9) was compar...
Asai, Nobuhiro Nakamura, Akiko Sakanashi, Daisuke Koita, Isao Ohashi, Wataru Kawamoto, Yuzuka Miyazaki, Narimi Ohno, Tomoko Yamada, Atsuko Chida, Sumie
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Published in
Journal of Infection and Chemotherapy
Introduction The pandemic of a novel coronavirus disease 2019 (COVID-19) caused by a severe acute respiratory coronavirus 2 (SARS-CoV-2) infection has been problematic worldwide. A new SARS-CoV-2 diagnostic test (SmartAmp) was licensed in Japan in July 2021. This method, which enables us to diagnose COVID-19 as well as a gene mutation on the virus,...
Yoshifuji, Ayumi Ishioka, Kota Masuzawa, Yuya Suda, Shuntaro Murata, Saori Uwamino, Yoshifumi Fujino, Motoko Miyahara, Hiromi Hasegawa, Naoki Ryuzaki, Munekazu
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Published in
Journal of Infection and Chemotherapy
A 60-year-old man presented with dyspnea four days after the second dose of the coronavirus disease (COVID-19) vaccine. Imaging revealed extensive ground-glass opacification. Blood tests were notable for elevated KL-6 levels. Bronchoalveolar lavage fluid analysis showed increased lymphocyte-dominant inflammatory cells and decreased CD4/CD8 ratio. T...
Saita, Mizue Yan, Yan Ito, Kanami Sasano, Hiroshi Seyama, Kuniaki Naito, Toshio
Published in
Journal of Infection and Chemotherapy
As the first authorized COVID-19 vaccine in Japan, the BNT162b2 mRNA COVID-19 vaccine is utilized for mass vaccination. Although efficacy has been proved, real-world evidence on reactogenicity in Japanese personnel is needed to prepare the public. Healthcare workers in a large academic hospital in Japan received two doses of the Pfizer-BioNTech vac...
Nomura, Toshihito Kitagawa, Hiroki Omori, Keitaro Shigemoto, Norifumi Kakimoto, Masaki Nazmul, Tanuza Shime, Nobuaki Sakaguchi, Takemasa Ohge, Hiroki
Published in
Journal of Infection and Chemotherapy
Background Approximately 5% of patients with coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 develop severe COVID-19. Severe COVID-19 requires respiratory management with mechanical ventilation and an extended period of treatment. Prolonged infectious virus shedding is a concern in severe COVID-19 cases, but...
Mohan, Anant Tiwari, Pawan Suri, Tejas Menon Mittal, Saurabh Patel, Ankit Jain, Avinash Velpandian, Thirumurthy Das, Ujjalkumar Subhash Boppana, Tarun Krishna Pandey, Ravindra Mohan
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Published in
Journal of Infection and Chemotherapy
Introduction Ivermectin is an antiparasitic drug which has in-vitro efficacy in reducing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viral load. Hence, Ivermectin is under investigation as a repurposed agent for treating COVID-19. Methods In this pilot, double blind, randomized controlled trial, hospitalized patients with mild-to-m...
Zóka, András Bekő, Gabriella
Published in
Journal of Infection and Chemotherapy
Goto, Norihiko Wada, Yosuke Ikuyama, Yuichi Akahane, Jumpei Kosaka, Makoto Ushiki, Atsuhito Kitaguchi, Yoshiaki Yasuo, Masanori Yamamoto, Hiroshi Matsuo, Akemi
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Published in
Journal of Infection and Chemotherapy
Introduction Risk factors for seriously ill coronavirus disease 19 (COVID-19) patients have been reported in several studies. However, to date, few studies have reported simple risk assessment tools for distinguishing patients becoming severely ill after initial diagnosis. Hence, this study aimed to develop a simple clinical risk nomogram predictin...
