Liu, Dong Chen, Zhifu Yuan, Yue Jing, Haiming Zou, Jintao Zhang, Xiaoli Zeng, Xi Zhang, Weijun Zou, Quanming Zhang, Jinyong
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Published in
Journal of Immunology Research
Innate immune effectors constitute the first line of host defense against pathogens. However, the roles of these effectors are not clearly defined during Klebsiella pneumoniae ( K. pneumoniae ) respiratory infection. In the current study, we established an acute pneumonia model of K. pneumoniae respiratory infection in mice and confirmed that the i...
Zhou, Wei Shen, Qin Wang, Hui Yang, Jie Zhang, Chen Deng, Zijing Wu, Keyan Zhou, Yang Zeng, Jing Zhang, Yu
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Published in
Journal of Immunology Research
The purpose of this study was to investigate the effect of knockdown of the yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) on the migration and invasion of the rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) and to preliminarily elucidate the mechanisms between YAP/TAZ and autophagy in the migra...
Zhang, Tian-Ping Li, Rui Huang, Qian Pan, Han-Feng Ye, Dong-Qing Li, Xiao-Mei
Published in
Journal of Immunology Research
Objective Recent studies have focused on the special roles of NADPH-oxidase in multiple autoimmune diseases. Nevertheless, the association of genetic variation in NADPH-oxidase genes with rheumatoid arthritis (RA) was not extensively studied in a Chinese population. We performed this study to examine the association of NCF2 , NCF4 , and CYBA gene p...
Lu, Yan Wang, Yajun Zhang, Zhen Huang, Jingliang Yao, Meicun Huang, Guobin Ge, Yuanyuan Zhang, Peichun Huang, Huaxin Wang, Yong
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Published in
Journal of immunology research
This new decade has started with a global pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), precipitating a worldwide health crisis and economic downturn. Scientists and clinicians have been racing against time to find therapies for COVID-19. Repurposing approved drugs, developing vaccines and employing pa...
Ding, Shaoxue Liang, Xiaowei Zhang, Tian Fu, Rong
Published in
Journal of Immunology Research
Severe aplastic anemia (SAA) is a rare disease characterized by severe pancytopenia and bone marrow failure. Most patients with AA respond to immunosuppressive therapy (IST), usually as antithymocyte globulin (ATG) and cyclosporine (CsA), but some relapse on CsA withdrawal or require long-term administration of CsA to maintain blood counts. Recent ...
Figueiredo, Barbara Castro-Pimentel Pinheiro, Carina Silva Marinho, Fabio Vitarelli Guerrero, Nestor Adrian
Published in
Journal of Immunology Research
Tian, Feng Lu, Qiang Lei, Jie Ni, Yunfeng Xie, Nianlin Zhong, Daixing Yang, Guang Si, Shaokui Jiang, Tao
Published in
Journal of Immunology Research
In this study, the effects of single immunoglobin IL-1 receptor-related protein (SIGIRR) on tumor necrosis factor- (TNF-) receptor-associated factor 6 (TRAF6) ubiquitination in acute lung injury (ALI) were evaluated in both alveolar epithelial cells and alveolar macrophage cells in vitro. Our results found that SIGIRR negatively regulated TRAF6 ubi...
Chen, Yanhong Chen, Yongqiang Zu, Beibei Liu, Jia Sun, Li Ding, Chen Wang, Duping Cheng, Xing Yang, DeLiang Niu, Guoping
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Published in
Journal of Immunology Research
Objective To evaluate the plasma levels of lnc-DC in primary Sjögren's syndrome (pSS) patients and investigate the potential associations between lnc-DC and disease activity. Methods In this study, we recruited 358 enrollments, including 127 pSS patients without immune thrombocytopenia (ITP), 22 pSS patients with ITP, 50 systemic lupus erythematosu...
Yuan, Yuan Wu, Wei Sun, Shanshan Zhang, Yi Chen, Zhi
Published in
Journal of Immunology Research
Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is often upregulated in the presence of sepsis and infectious diseases. In sepsis, PCSK9 degraded the low-density lipoprotein cholesterol (LDL) receptors (LDL-R) of the hepatocytes and th...
Xiao, Li He, Yumin Peng, Fan Yang, Jianlin Yuan, Chengfu
Published in
Journal of Immunology Research
Increasing evidence has demonstrated that hypoxia was an aggressive feature in endometrial cancer (EC), which is significantly associated with the tumor grade, lymph node metastasis, and tumor resistance to chemotherapy. However, the relationship between hypoxia and the immune microenvironment in EC is not very clear. Exosomes are small membrane ve...
