Wang, Jian Xiang, Bo Deng, Ji-xian Lin, Hung-yu Freed, Darren H. Arora, Rakesh C. Tian, Gang-hong
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
Adipose-derived stem cells (ASCs) induce therapeutic angiogenesis due to pro-angiogenic cytokines secretion. Superparamagnetic iron oxide (SPIO) nanoparticles are critical for magnetic resonance (MR) tracking of implanted cells. Hypoxia is a powerful stimulus for angiogenic activity of ASCs. In this study, we investigated whether therapeutic potenc...
Fang, Mao-sheng Li, Xing Qian, Hong Zeng, Kuan Ye, Meng Zhou, Yong-jie Li, Hui Wang, Xiao-chuan Li, Yi
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
This study was to determine the protective effect of ω-3 polyunsaturated fatty acids (ω-3PUFAs) on MK-801-induced cognitive impairment in schizophrenia (SZ) rats and the underlying mechanism. A rat model of schizophrenia was induced by MK-801. The cognitive function of rats was assessed using a Morris water maze. The number of hippocampal neurons w...
Zhao, Yue Hou, Ling Gao, Hong-jie Zhan, Di Zhang, Cai Luo, Xiao-ping
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
The effect of obesity on idiopathic central precocious puberty (ICPP) girls is still under discussion. The relationship between body mass index (BMI) and sexual hormone levels of gonadotropin-releasing hormone (GnRH) stimulation test in ICPP girls is controversial and the underlying mechanism is unclear. This study aims to further explore the indep...
Zhang, Hu Zhang, Hui Li, Hui Zhang, Heng Zheng, Dan Sun, Chen-ming Wu, Jie
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
Endoscopic therapy (ET) is most common method for preventing variceal bleeding in cirrhosis, but the outcomes are not perfect. Recently, transjugular intrahepatic portosystemic shunt (TIPS) is introduced into clinical practice. However, the beneficial effects of TIPS compared to ET on cirrhotic patients is unknown. The aim of this study was to eval...
Nie, Li Zhao, Ya-nan Luo, Hong-yan Hu, Xin-wu Zhang, Liang-pin Liang, Hua-min
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
This study aimed to examine the functional role of microRNA-20 (miR-20) and its potential target, Kir6.1, in ischemic myocardiocytes. The expression of miR-20 was detected by real-time PCR. Myocardiocytes were stained with terminal deoxynucleotidyl transferase dUTP nick end labeling (TU-NEL) reagent for apoptosis evaluation. Western blotting was us...
Lin, Rong Han, Chao-qun Wang, Wei-jun Liu, Jun Qian, Wei Ding, Zhen Hou, Xiao-hua
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
Survival after pancreatic cancer surgery is extremely unfavorable even after curative resection. Prognostic factors have been explored but remain largely undefined. The present study was to identify the role of clinical and laboratory variables in the prognostic significance of resectable pancreatic adenocarcinoma. A total of 96 patients who underw...
Pan, Yan-feng Su, Tong Chen, Li-dan Qin, Tao
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
The differential expression of genes in HepG2 cells caused by UC001kfo RNAi was investigated using RNA-seq. HepG2 cells were infected by Lenti-shUC001kfo lentivirus particles. The expression of UC001kfo mRNA in the HepG2-shUC001kfo cell line was detected by real-time PCR. RNA-seq technology was used to identify the difference in the expression of g...
Liu, Hong-mei Liu, Yi-tong Zhang, Jing Ma, Li-jun
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
The anti-inflammatory and antibacterial mechanisms of bone marrow mesenchymal stem cells (MSCs) ameliorating lung injury in chronic obstructive pulmonary disease (COPD) mice induced by cigarette smoke and Haemophilus Parainfluenza (HPi) were studied. The experiment was divided into four groups in vivo: control group, COPD group, COPD+HPi group, and...
Cao, Hai-yan Wang, Yu Hong, Liu Han, Wei He, Lin Song, Ben-cai Hu, Yun-fei Peng, Yuan Wang, Bin Wang, Jing
...
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
Accurate prenatal diagnosis of complex congenital cardiovascular anomalies, vascular ones in particular, is still challenging. A fetal cardiovascular cast model can provide a copy of the cardiac chambers and great vessels with normal or pathological structures. This study was aimed to demonstrate three-dimensional anatomy of complex congenital card...
Li, Hong Wang, Hua Peng, Cheng Zheng, Xin Liu, Jia Weng, Zhi-hong Yang, Dong-liang
Published in
Journal of Huazhong University of Science and Technology [Medical Sciences]
This study aims to explore the efficacy of interferon-α (IFN-α) combined with either entecavir (ETV) or adefovir (ADV) therapy versus IFN-α mono-therapy for chronic hepatitis B (CHB) patients, and to identify the factors associated with treatment outcomes. Totally, 159 CHB patients receiving interferon-based treatment for 48 weeks were enrolled in ...
