Zuo, Xueliang Chen, Zhiqiang Gao, Wen Zhang, Yao Wang, Jinguo Wang, Junfeng Cao, Ming Cai, Juan Wu, Jindao Wang, Xuehao
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Published in
Journal of Hematology & Oncology
BackgroundLong non-coding RNAs (lncRNAs) possess significant regulatory functions in multiple biological and pathological processes, especially in cancer. Dysregulated lncRNAs in hepatocellular carcinoma (HCC) and their therapeutic applications remain unclear.MethodsDifferentially expressed lncRNA profile in HCC was constructed using TCGA data. LIN...
Yoshida, Go J.
Published in
Journal of Hematology & Oncology
Patient-derived tumor xenografts (PDXs), in which tumor fragments surgically dissected from cancer patients are directly transplanted into immunodeficient mice, have emerged as a useful model for translational research aimed at facilitating precision medicine. PDX susceptibility to anti-cancer drugs is closely correlated with clinical data in patie...
Yang, Lu-Yu Luo, Qin Lu, Lu Zhu, Wen-Wei Sun, Hao-Ting Wei, Ran Lin, Zhi-Fei Wang, Xiang-Yu Wang, Chao-Qun Lu, Ming
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Published in
Journal of Hematology & Oncology
BackgroundThe propensity of the activated neutrophils to form extracellular traps (NETs) is demonstrated in multiple inflammatory conditions. In this study, we investigated the roles of NETs in metastasis of hepatocellular carcinoma (HCC) and further explored the underlying mechanism of how NETs affect metastasis as well as the therapeutic value.Me...
Abbasi, Ahmed Peeke, Stephen Shah, Nishi Mustafa, Jennat Khatun, Fariha Lombardo, Amanda Abreu, Michelly Elkind, Richard Fehn, Karen de Castro, Alyssa
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Published in
Journal of Hematology & Oncology
Axicabtagene ciloleucel (Axi-cel) is a CD-19 Chimeric Antigen Receptor T cell therapy approved for the treatment of relapsed/refractory diffuse large B cell lymphoma. We treated ten patients with DLBCL post-FDA approval in an inner-city tertiary center in the Bronx. Eight patients (80%) had received ≥ 3 lines of therapy, six patients had received p...
Zhu, Qian Zhong, Ai-Lin Hu, Hao Zhao, Jing-Jing Weng, De-Sheng Tang, Yan Pan, Qiu-Zhong Zhou, Zi-Qi Song, Meng-Jia Yang, Jie-Ying
...
Published in
Journal of Hematology & Oncology
BackgroundClinically, the median survival in patients with metastatic renal cell carcinoma (RCC) was only 6–12 months and a 5-year survival rate of less than 20%. Therefore, an in-depth study of the molecular mechanisms involved in RCC is of great significance for improving the survival of patients with advanced RCC. Acylglycerol kinase (AGK) is a ...
Tsimberidou, Apostolia-Maria Hong, David S. Wheler, Jennifer J. Falchook, Gerald S. Janku, Filip Naing, Aung Fu, Siqing Piha-Paul, Sarina Cartwright, Carrie Broaddus, Russell R.
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Published in
Journal of Hematology & Oncology
BackgroundIn 2007, we initiated IMPACT, a precision medicine program for patients referred for participation in early-phase clinical trials. We assessed the correlation of factors, including genomically matched therapy, with overall survival (OS).Patients and methodsWe performed molecular profiling (Clinical Laboratory Improvement Amendments) (gene...
Zhao, Kai Zhou, Yuxin Qiao, Chen Ni, Ting Li, Zhiyu Wang, Xiaotang Guo, Qinglong Lu, Na Wei, Libin
Published in
Journal of Hematology & Oncology
The original article [1] contains several errors.
Ogawa, Kosuke Lin, Qiushi Li, Le Bai, Xuewei Chen, Xuesong Chen, Hua Kong, Rui Wang, Yongwei Zhu, Hong He, Fuliang
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Published in
Journal of Hematology & Oncology
BackgroundSignaling pathways critical for embryonic development re-emerge in adult pancreas during tumorigenesis. Aspartate β-hydroxylase (ASPH) drives embryonic cell motility/invasion in pancreatic development/differentiation. We explored if dysregulated ASPH is critically involved in pancreatic cancer pathogenesis.MethodsTo demonstrate if/how ASP...
Fan, Han Demirci, Utkan Chen, Pu
Published in
Journal of Hematology & Oncology
Cancer heterogeneity is regarded as the main reason for the failure of conventional cancer therapy. The ability to reconstruct intra- and interpatient heterogeneity in cancer models is crucial for understanding cancer biology as well as for developing personalized anti-cancer therapy. Cancer organoids represent an emerging approach for creating pat...
Fleischer, Lauren C. Spencer, H. Trent Raikar, Sunil S.
Published in
Journal of Hematology & Oncology
Chimeric antigen receptor (CAR) T cell therapy has been successful in treating B cell malignancies in clinical trials; however, fewer studies have evaluated CAR T cell therapy for the treatment of T cell malignancies. There are many challenges in translating this therapy for T cell disease, including fratricide, T cell aplasia, and product contamin...
