Brissot, Eolia Labopin, Myriam Moiseev, Ian Cornelissen, J. J. Meijer, Ellen Van Gorkom, Gwendolyn Rovira, Montserrat Ciceri, Fabio Griskevicius, Laimonas Blaise, Didier
...
Published in
Journal of Hematology & Oncology
BackgroundGraft-versus-host disease (GVHD) remains a major contributor to mortality and morbidity after allogeneic stem-cell transplantation (allo-HSCT). The updated recommendations suggest that rabbit antithymocyte globulin or anti-T-lymphocyte globulin (ATG) should be used for GVHD prophylaxis in patients undergoing matched-unrelated donor (MUD) ...
Kong, Yanguo Kong, Xiangyi He, Cheng Liu, Changsong Wang, Liting Su, Lijuan Gao, Jun Guo, Qi Cheng, Ran
Published in
Journal of Hematology & Oncology
Due to acromegaly’s insidious onset and slow progression, its diagnosis is usually delayed, thus causing severe complications and treatment difficulty. A convenient screening method is imperative. Based on our previous work, we herein developed a new automatic diagnosis and severity-classification model for acromegaly using facial photographs by de...
Huang, Ruihao Li, Xiaoping He, Yundi Zhu, Wen Gao, Lei Liu, Yao Gao, Li Wen, Qin Zhong, Jiang F. Zhang, Cheng
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Published in
Journal of Hematology & Oncology
Chimeric antigen receptor T (CAR-T) cell therapy is regarded as an effective solution for relapsed or refractory tumors, particularly for hematological malignancies. Although the initially approved anti-CD19 CAR-T therapy has produced impressive outcomes, setbacks such as high relapse rates and resistance were experienced, driving the need to disco...
Zhang, Shu Liu, Yuming Chen, Jing Shu, Hong Shen, Siyun Li, Yin Lu, Xinyuan Cao, Xinyi Dong, Liangqing Shi, Jieyi
...
Published in
Journal of Hematology & Oncology
BackgroundAlpha-fetoprotein (AFP) is a widely used biomarker for hepatocellular carcinoma (HCC) early detection. However, low sensitivity and false negativity of AFP raise the requirement of more effective early diagnostic approaches for HCC.MethodsWe employed a three-phase strategy to identify serum autoantibody (AAb) signature for HCC early diagn...
Huang, Xing Zhang, Xiaozhen Li, Enliang Zhang, Gang Wang, Xun Tang, Tianyu Bai, Xueli Liang, Tingbo
Published in
Journal of Hematology & Oncology
VISTA (V-domain immunoglobulin suppressor of T cell activation) is a well-established immune regulatory receptor. However, pre-clinical investigations indicated more complicated influences of VISTA on cancer immunity than previously recognized. Here, we review the current knowledge on the therapeutic phenotypes and molecular mechanisms that underli...
Hemminki, Otto dos Santos, João Manuel Hemminki, Akseli
Published in
Journal of Hematology & Oncology
In this review, we discuss the use of oncolytic viruses in cancer immunotherapy treatments in general, with a particular focus on adenoviruses. These serve as a model to elucidate how versatile viruses are, and how they can be used to complement other cancer therapies to gain optimal patient benefits. Historical reports from over a hundred years su...
Burgos, Leire Puig, Noemi Cedena, Maria-Teresa Mateos, María-Victoria Lahuerta, Juan José Paiva, Bruno San-Miguel, Jesús F.
Published in
Journal of Hematology & Oncology
The landscape of multiple myeloma (MM) has changed considerably in the past two decades regarding new treatments, insight into disease biology and innovation in the techniques available to assess measurable residual disease (MRD) as the most accurate method to evaluate treatment efficacy. The sensitivity and standardization achieved by these techni...
Jiang, Minlin Chen, Peixin Wang, Lei Li, Wei Chen, Bin Liu, Yu Wang, Hao Zhao, Sha Ye, Lingyun He, Yayi
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Published in
Journal of Hematology & Oncology
Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therapy study with great results achieved in pre-clinical work. Recent progress in the mechanical understanding of STING pathway in IFN production ...
Xiao, Xinhua Liu, Ping Li, Donghe Xia, Zhizhou Wang, Peihong Zhang, Xiuli Liu, Mingzhu Liao, Lujian Jiao, Bo Ren, Ruibao
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Published in
Journal of Hematology & Oncology
BackgroundThe Philadelphia chromosome (Ph), which leads to the creation and expression of the fusion gene product BCR-ABL, underlines the pathogenesis of chronic myelogenous leukemia (CML) and a fraction of adult and pediatric acute B-lymphoblastic leukemia (B-ALL). The BCR-ABL tyrosine kinase inhibitors (TKIs) have shown a remarkable clinical acti...
Wang, Wen-Tao Chen, Tian-Qi Zeng, Zhan-Cheng Pan, Qi Huang, Wei Han, Cai Fang, Ke Sun, Lin-Yu Yang, Qian-Qian Wang, Dan
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Published in
Journal of Hematology & Oncology
BackgroundMixed-lineage leukemia (MLL) gene rearrangements trigger aberrant epigenetic modification and gene expression in hematopoietic stem and progenitor cells, which generates one of the most aggressive subtypes of leukemia with an apex self-renewal. It remains a challenge to directly inhibit rearranged MLL itself because of its multiple fusion...
