Li, Dongxiao Ding, Xiangming Xie, Meng Tian, Dean Xia, Limin
Published in
Journal of Gastroenterology
The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a global challenge since December 2019. Although most patients with COVID-19 exhibit mild clinical manifestations, in approximately 5% of these patients, the disease eventually progresses to severe lung injury or eve...
Kudo, Masatoshi Tsuchiya, Kaoru Kato, Naoya Hagihara, Atsushi Numata, Kazushi Aikata, Hiroshi Inaba, Yoshitaka Kondo, Shunsuke Motomura, Kenta Furuse, Junji
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Published in
Journal of Gastroenterology
Background To evaluate the efficacy and safety of cabozantinib in Japanese patients with advanced hepatocellular carcinoma (HCC) who had progressed following one or two lines of systemic therapy including sorafenib. An exploratory evaluation in sorafenib-naïve patients was performed. Methods In this open-label, single-arm, phase 2 trial, patients r...
Ochi, Hironori Hiraoka, Atsushi Hirooka, Masashi Koizumi, Yohei Amano, Michiko Azemoto, Nobuaki Watanabe, Takao Yoshida, Osamu Tokumoto, Yoshio Mashiba, Toshie
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Published in
Journal of Gastroenterology
Background The effects of direct-acting antivirals (DAAs) on survival and recurrence rates after curative hepatocellular carcinoma (HCC) treatment in patients with hepatitis C virus (HCV) infection remain controversial. Methods This retrospective, multicenter study involved Child–Pugh class A patients within the Milan criteria who had a first diagn...
Enomoto, Hirayuki Ueno, Yoshiyuki Hiasa, Yoichi Nishikawa, Hiroki Hige, Shuhei Takikawa, Yasuhiro Taniai, Makiko Ishikawa, Toru Yasui, Kohichiroh Takaki, Akinobu
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Published in
Journal of Gastroenterology
Background We recently reported the real-world changes in the etiologies of liver cirrhosis (LC) based on nationwide survey data and assessed the etiologies of LC with hepatocellular carcinoma (HCC). Methods Fifty-five participants from 68 institutions provided data on 23,637 patients with HCC-complicated LC. The changing trends in etiologies were ...
Jiang, Lu Stärkel, Peter Fan, Jian-Gao Fouts, Derrick Eugene Bacher, Petra Schnabl, Bernd
Published in
Journal of Gastroenterology
The human gut microbiome (bacteria, fungi, viruses, and archaea) is a complex and diverse ecosystem. It plays an important role in human health, but is involved in several intestinal and extraintestinal diseases. Most research to date has focused on the role of bacteria, while studies focusing on fungi (also referred to as “mycobiome” or “fungome”)...
Kita, Toshihiro Ashizuka, Sinya Ohmiya, Naoki Yamamoto, Takayuki Kanai, Takanori Motoya, Satoshi Hirai, Fumihito Nakase, Hiroshi Moriyama, Tomohiko Nakamura, Masanao
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Published in
Journal of gastroenterology
Adrenomedullin (AM) is a bioactive peptide having many pleiotropic effects, including mucosal healing and immunomodulation. AM has shown beneficial effects in rodent models and in preliminary study for patients with ulcerative colitis (UC). We performed a clinical trial to investigate the efficacy and safety of AM in patients with UC. This was a mu...
Zhang, Mengyu Yaman, Busra Roman, Sabine Savarino, Edoardo Gyawali, C. Prakash Gardner, Jerry D. Sifrim, Daniel
Published in
Journal of Gastroenterology
Background and aims The underlying physiology of post-reflux swallow-induced peristaltic wave (PSPW) is unclear. We aimed to: 1) calculate the probability of a random association between reflux and PSPW; 2) characterize factors that could underlie triggering of PSPW and 3) assess the chemical clearance effect of PSPW in healthy asymptomatic subject...
Yip, Terry Cheuk-Fung Lai, Jimmy Che-To Wong, Grace Lai-Hung
Published in
Journal of Gastroenterology
Reducing the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) is the key ultimate goal set in essentially all treatment guidelines. There has been solid evidence supporting the relationship between serum hepatitis B virus (HBV) DNA level and risk of HCC. Antiviral treatment with oral nucleos(t)ide analogues (NA...
Koterazawa, Yasufumi Koyanagi-Aoi, Michiyo Uehara, Keiichiro Kakeji, Yoshihiro Aoi, Takashi
Published in
Journal of Gastroenterology
Sawada, Akinari Itami, Hideaki Nakagawa, Kenichiro Hirano, Shinji Kitamura, Hiroyuki Nakata, Rieko Takashima, Shingo Abe, Yasuaki Saito, Masahiro Yazaki, Etsuro
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Published in
Journal of Gastroenterology
Background Supragastric belching (SGB) may play a role in the pathophysiology of proton pump inhibitors (PPIs)-refractoriness in gastroesophageal reflux disease (GERD). SGB may be present in up to 40% of reflux symptoms in PPI-refractory GERD. Most reports on SGB have come from Western countries, and little is known about the prevalence and relevan...