Published in Journal of Experimental Pharmacology
Introduction Leishmaniasis is a group of diseases caused by protozoan parasites, which remains a burden for developing countries. The lack of a vaccine as well as the emergence of resistance toward the recommended drugs pose a challenge for the control of the disease. This urges the demand for new antileishmanial agents to prevent and treat this di...
Published in Journal of Experimental Pharmacology
The coronavirus infectious disease-2019 (COVID-19) has overwhelmed like a shock wave in a completely unprepared world. Despite coronavirus infections were involved in previous epidemic outbreaks, no antiviral agent was developed for specific treatment. As a consequence, since the beginning of this pandemic, both repositioned and experimental drugs ...
Published in Journal of Experimental Pharmacology
Background A current challenge in malaria control and elimination is the progressive resistance to most antimalarial drugs which necessitates the discovery of new options. Hence, the current study was initiated to investigate the antimalarial activity of the stem bark of Fagaropsis angolensis in mice. Methods The test material was extracted using 8...
Published in Journal of Experimental Pharmacology
Treatment-resistance is a frequent condition for obsessive-compulsive disorder (OCD). Over the past decades, a lot of effort has been made to address this issue, and several augmentation strategies of serotonergic drugs have been investigated. Antidopaminergic drugs are considered the first choice as augmentation strategy for treatment-resistant OC...
Published in Journal of Experimental Pharmacology
Background The demand for traditional herbal medicine is increasing and about 85% of the world population use herbal medicines for the prevention and treatment of diseases. More than 62.5% of the forest areas in Ethiopia are found in the southwest region, which have been used as a source of traditional medicine to treat different human and livestoc...
Published in Journal of Experimental Pharmacology
Purpose Although the onset mechanism of Alzheimer’s disease, which co-occurs with aging, has been extensively studied, no effective methods that improve the decline in memory and learning abilities following aging have been developed. Tranexamic acid provided promising results for ameliorating photo-aging and extending the natural lifespan. However...
Published in Journal of Experimental Pharmacology
The standard therapy for primary biliary cholangitis (PBC) is ursodeoxycholic acid (UDCA) which has shown to improve hepatic biochemistry, delay histological progression and improve transplant-free survival. Approximately 30–40% of patients do not respond or are intolerant to UDCA. Obeticholic acid, a farnesoid X receptor (FXR) agonist is the only ...
Published in Journal of Experimental Pharmacology
Background In Ethiopian folk medicine Podocarpus falcactus is used to treat stomachache, cancer, diabetes, and difficulty of urination. However, its diuretic activity has not been proven scientifically. Objective To determine the diuretic activity and phytochemical contents of the aqueous extract of the shoot apexes of Podocarpus falcactus . Method...
Published in Journal of Experimental Pharmacology
Background Although investigations on different pharmacological activities of the experimental plant, Ficus sur have been conducted, its folklore use for diuresis has not yet been validated. The current study, therefore, focused on the diuretic activity of aqueous and 80% methanol extracts of F. sur Forssk. leaves in rats. Methods Rats were randoml...
Published in Journal of Experimental Pharmacology
Carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII are overexpressed in many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation cascade, being present in limited amounts in normal tissues. These enzymes together with many others are involved in the pH regulation and metabolism of hypoxic cancer cells, and were val...
