Izawa, Kazushi Martin, Emmanuel Soudais, Claire Bruneau, Julie Boutboul, David Rodriguez, Rémy Lenoir, Christelle Hislop, Andrew D. Besson, Caroline Touzot, Fabien
...
Published in
Journal of Experimental Medicine
Epstein-Barr virus (EBV) infection in humans is a major trigger of malignant and nonmalignant B cell proliferations. CD27 is a co-stimulatory molecule of T cells, and inherited CD27 deficiency is characterized by high susceptibility to EBV infection, though the underlying pathological mechanisms have not yet been identified. In this study, we repor...
Zhang, Shu Pondarre, Corinne Pennarun, Gaelle Labussiere-Wallet, Helene Vera, Gabriella France, Benoit Chansel, Marie Rouvet, Isabelle Revy, Patrick Lopez, Bernard
...
Published in
The Journal of experimental medicine
Inherited bone marrow failure syndromes are human conditions in which one or several cell lineages of the hemopoietic system are affected. They are present at birth or may develop progressively. They are sometimes accompanied by other developmental anomalies. Three main molecular causes have been recognized to result in bone marrow failure syndrome...
Lim, Ai Ing Menegatti, Silvia Bustamante, Jacinta Le Bourhis, Lionel Matthieu Allez Rogge, Lars Jean-Laurent Casanova Yssel, Hans Di Santo, James P.
Published in
Journal of Experimental Medicine
Group 2 innate lymphoid cells (ILC2) include IL-5- and IL-13-producing CRTh2(+)CD127(+)cells that are implicated in early protective immunity at mucosal surfaces. Whereas functional plasticity has been demonstrated for both human and mouse ILC3 subsets that can reversibly give rise to IFN-γ-producing ILC1, plasticity of human or mouse ILC2 has not ...
Ramírez-Alejo, Noé Kilic, Sara Sebnem El Baghdadi, Jamila Nonoyama, Shigeaki Mahdaviani, Seyed Alireza Ailal, Fatima Bousfiha, Aziz Mansouri, Davood Nievas, Elma Ma, Cindy S.
...
Published in
Journal of Experimental Medicine
Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1) with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES), including atopic dermatitis, high serum IgE levels, and staphylococcal abscesses. We identified seven other TYK2-deficient patients from five families and four differen...
Bourgeois, Elvire A Subramaniam, Sumithra Cheng, Tan-Yun De Jong, Annemieke Layre, Emilie Ly, Dalam Salimi, Maryam Legaspi, Annaliza Modlin, Robert L Salio, Mariolina
...
Published in
The Journal of experimental medicine
Venoms frequently co-opt host immune responses, so study of their mode of action can provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a model system, we investigated whether venoms contain CD1-presented antigens. Here, we show that venoms activate human T cells via CD1a proteins. Whereas CD1 proteins typically...
Cursio, Raffaele Colosetti, Pascal Patrice Codogno Cuervo, Ana Maria Shen, Han-Ming
Published in
Journal of Experimental Medicine
Mirsoian, Annie Bouchlaka, Myriam N Sckisel, Gail D Chen, Mingyi Pai, Chien-Chun Steven Maverakis, Emanuel Spencer, Richard G Fishbein, Kenneth W Siddiqui, Sana Monjazeb, Arta M
...
Published in
The Journal of experimental medicine
Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm. We found that aging was accompanied by increases in visceral fat similar to that seen in young obese (ob/ob or diet-induced obese [DIO]) ...
Descatoire, Marc Jean-Claude Weill Irtan, Sabine Sabine Sarnacki Feuillard, Jean Storck, Sébastien Guiochon-Mantel, Anne Bouligand, Jérôme Morali, Alain Cohen, Joseph
...
Published in
Journal of Experimental Medicine
Mouse splenic marginal zone precursors (MZPs) differentiate into marginal zone B (MZB) cells under a signaling pathway involving Notch2 and its ligand, delta-like 1 ligand (Dll1). We report the identification of an MZP subset in the spleen of young children. These MZPs differentiate into MZ-like B cells in vitro in the presence of OP9 cells express...
Krogsgaard, Michelle
Published in
Trends in Immunology
T cell development requires recognition of self-peptides in the thymus. Two recent studies by Allen and colleagues shed new light into the connection between self-recognition during positive selection and recognition of foreign antigen in the periphery.
Enervald, Elin Du, Likun Visnes, Torkild Björkman, Andrea Lindgren, Emma Wincent, Josephine Borck, Guntram Colleaux, Laurence Cormier-Daire, Valerie van Gent, Dik C
...
Published in
The Journal of experimental medicine
DNA double strand breaks (DSBs) are mainly repaired via homologous recombination (HR) or nonhomologous end joining (NHEJ). These breaks pose severe threats to genome integrity but can also be necessary intermediates of normal cellular processes such as immunoglobulin class switch recombination (CSR). During CSR, DSBs are produced in the G1 phase of...
