Izawa, Kazushi Martin, Emmanuel Soudais, Claire Bruneau, Julie Boutboul, David Rodriguez, Rémy Lenoir, Christelle Hislop, Andrew D Besson, Caroline Touzot, Fabien
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Published in
The Journal of experimental medicine
Epstein-Barr virus (EBV) infection in humans is a major trigger of malignant and nonmalignant B cell proliferations. CD27 is a co-stimulatory molecule of T cells, and inherited CD27 deficiency is characterized by high susceptibility to EBV infection, though the underlying pathological mechanisms have not yet been identified. In this study, we repor...
Bachy, Emmanuel Urb, Mirjam Chandra, Shilpi Robinot, Rémy Bricard, Gabriel De Bernard, Simon Traverse-Glehen, Alexandra Gazzo, Sophie Blond, Olivier Khurana, Archana
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Published in
Journal of Experimental Medicine
Peripheral T cell lymphomas (PTCLs) are a heterogeneous entity of neoplasms with poor prognosis, lack of effective therapies, and a largely unknown pathophysiology. Identifying the mechanism of lymphomagenesis and cell-of-origin from which PTCLs arise is crucial for the development of efficient treatment strategies. In addition to the well-describe...
Zhang, Shu Pondarre, Corinne Pennarun, Gaelle Labussiere-Wallet, Helene Vera, Gabriella France, Benoit Chansel, Marie Rouvet, Isabelle Revy, Patrick Lopez, Bernard
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Published in
The Journal of experimental medicine
Inherited bone marrow failure syndromes are human conditions in which one or several cell lineages of the hemopoietic system are affected. They are present at birth or may develop progressively. They are sometimes accompanied by other developmental anomalies. Three main molecular causes have been recognized to result in bone marrow failure syndrome...
Lim, Ai Ing Menegatti, Silvia Bustamante, Jacinta Le Bourhis, Lionel Matthieu Allez Rogge, Lars Jean-Laurent Casanova Yssel, Hans Di Santo, James P.
Published in
Journal of Experimental Medicine
Group 2 innate lymphoid cells (ILC2) include IL-5- and IL-13-producing CRTh2(+)CD127(+)cells that are implicated in early protective immunity at mucosal surfaces. Whereas functional plasticity has been demonstrated for both human and mouse ILC3 subsets that can reversibly give rise to IFN-γ-producing ILC1, plasticity of human or mouse ILC2 has not ...
Tesio, Melania Tang, Yilang Müdder, Katja Saini, Massimo von Paleske, Lisa Elizabeth Macintyre Pasparakis, Manolis Waisman, Ari Trumpp, Andreas
Published in
Journal of Experimental Medicine
The status of long-term quiescence and dormancy guarantees the integrity of hematopoietic stem cells (HSCs) during adult homeostasis. However the molecular mechanisms regulating HSC dormancy remain poorly understood. Here we show that cylindromatosis (CYLD), a tumor suppressor gene and negative regulator of NF-κB signaling with deubiquitinase activ...
Bourgeois, Elvire A Subramaniam, Sumithra Cheng, Tan-Yun De Jong, Annemieke Layre, Emilie Ly, Dalam Salimi, Maryam Legaspi, Annaliza Modlin, Robert L Salio, Mariolina
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Published in
The Journal of experimental medicine
Venoms frequently co-opt host immune responses, so study of their mode of action can provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a model system, we investigated whether venoms contain CD1-presented antigens. Here, we show that venoms activate human T cells via CD1a proteins. Whereas CD1 proteins typically...
Cursio, Raffaele Colosetti, Pascal Patrice Codogno Cuervo, Ana Maria Shen, Han-Ming
Published in
Journal of Experimental Medicine
Mirsoian, Annie Bouchlaka, Myriam N Sckisel, Gail D Chen, Mingyi Pai, Chien-Chun Steven Maverakis, Emanuel Spencer, Richard G Fishbein, Kenneth W Siddiqui, Sana Monjazeb, Arta M
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Published in
The Journal of experimental medicine
Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm. We found that aging was accompanied by increases in visceral fat similar to that seen in young obese (ob/ob or diet-induced obese [DIO]) ...
Cieslak, Agata Le Noir, Sandrine Trinquand, Amélie Lhermitte, Ludovic Franchini, Don-Marc Villarese, Patrick Gon, Stéphanie Bond, Jonathan Simonin, Mathieu Vanhille, Laurent
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Published in
Journal of Experimental Medicine
V(D)J recombination of TCR loci is regulated by chromatin accessibility to RAG1/2 proteins, rendering RAG1/2 targeting a potentially important regulator of lymphoid differentiation. We show that within the human TCR-α/δ locus, Dδ2-Dδ3 rearrangements occur at a very immature thymic, CD34(+)/CD1a(-)/CD7(+dim) stage, before Dδ2(Dδ3)-Jδ1 rearrangements...
Descatoire, Marc Jean-Claude Weill Irtan, Sabine Sabine Sarnacki Feuillard, Jean Storck, Sébastien Guiochon-Mantel, Anne Bouligand, Jérôme Morali, Alain Cohen, Joseph
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Published in
Journal of Experimental Medicine
Mouse splenic marginal zone precursors (MZPs) differentiate into marginal zone B (MZB) cells under a signaling pathway involving Notch2 and its ligand, delta-like 1 ligand (Dll1). We report the identification of an MZP subset in the spleen of young children. These MZPs differentiate into MZ-like B cells in vitro in the presence of OP9 cells express...
