Published in Journal of Drug and Alcohol Research
Morphine, used clinically for pain management for its potent analgesic effects, has a high abuse potential. In this study, we utilized the conditioned place preference (CPP) paradigm and tail-flick latency to examine the effects of the endotoxin lipopolysaccharide (LPS) on sensitivity to morphine. Rats were pretreated with either LPS (250 μg/kg) or...
Published in Journal of Drug and Alcohol Research
Background. Proximal and distal social stimulation increase ethanol drinking in humans. Purpose. Our study evaluated the effects of proximal and distal social stimulation on home-cage ethanol drinking in mice. Study design. Proximal cagemate drinking (PCD) procedures use a clear plastic barrier to separate the drinker mouse from the proximal cagema...
Published in Journal of Drug and Alcohol Research
Study design. The protective effects of the natural antiox-idant caffeic acid (CA) on behavioral tasks and lipid peroxidation were tested in an excitotoxic model produced by unilateral intrastriatal injection of quinolinic acid (QUIN), and in striatal slices incubated in the presence of the same toxin. CA (20 mg/kg) was administered intraperitoneal...
Published in Journal of Drug and Alcohol Research
Introduction. Because of obvious concerns, it is not possible to thoroughly explore the adverse effects of anesthetics in children. However, the availability of neural stem cell derived models has provided an invaluable tool to examine the etiology of neurotoxicity associated with developmental exposure to general anesthetics. Stem cells and neurot...
Published in Journal of Drug and Alcohol Research
Background. Different strains of rats have been used to study alcoholic liver disease (ALD) while the reason for selecting a particular rat strain was not apparent. Purpose. The aim of our study was to compare outbred (Wistar) and inbred (Fischer) strains to evaluate pathological, biochemical changes, and gene expression differences associated with...
Published in Journal of Drug and Alcohol Research
Background. Nicotine is one of the most frequently used drugs of abuse. It has long been speculated that in addition to nicotine , tobacco contains other compounds that reinforce addiction. Two promising candidates are the tobacco smoke constituents, harmane and norharmane. Purpose. Our study evaluated the effects of exposure to harmane and norharm...
Published in Journal of Drug and Alcohol Research
There is a general consensus in dentistry that successful local anesthesia is frequently difficult in habitual drinkers and alcoholic patients. Neuro-active tetrahydroharmans increase in human body fluids and tissues by consuming alcoholic beverages. To understand such reduced anesthetic efficacy by the drug interaction hypothesis, we studied the i...
Published in Journal of Drug and Alcohol Research
Methamphetamine (METH) is a psychostimulant abused worldwide and shown to be neurotoxic to both dopamine terminals and striatal neurons. Thus it would be advantageous to discover natural compounds that protect the brain from the METH-induced neural injury. In the present study, we tested the ability of epigallocatechin gallate (EGCG), the most abun...
Published in Journal of Drug and Alcohol Research
In addition to nicotine, there are a variety of other psychoac-tive compounds in tobacco smoke. Little is known about the interaction of these tobacco constituents on alcohol intake. In this study, we examined one of these constituents, anabasine, which acts on nicotinic receptors, for its effects on alcohol intake and preference in alcohol preferr...
Published in Journal of Drug and Alcohol Research
Previous research showed that repeated adolescent ±3,4-methylenedioxymethamphetamine (MDMA) treatments diminished the temperature dysregulation, hypoactivity/ " hangover " effect, and serotonin transporter reductions caused by a subsequent MDMA binge. This study evaluated whether MDMA would confer cross-tolerance against a methamphetamine (METH) bi...
