Ortiz-Masià, Dolores Salvador, Pedro Macias-Ceja, Dulce C Gisbert-Ferrándiz, Laura Esplugues, Juan V Manyé, Josep Alós, Rafael Navarro-Vicente, Francisco Mamie, Céline Scharl, Michael
...
Published in
Journal of Crohn's & colitis
Epithelial-mesenchymal transition [EMT] has been related to fibrosis and fistula formation, common complications associated with Crohn´s disease [CD]. The WNT signalling pathway mediates EMT, and specific WNT/FZD interactions have been related to the activation of this process in several diseases. We aim to analyse the relevance of EMT and WNT liga...
Novello, M Stocchi, L Steele, S R Holubar, S D Duraes, L C Kessler, H Shawki, S Hull, L T
Published in
Journal of Crohn's & colitis
The effects of vedolizumab [VEDO] exposure on perioperative outcomes following surgery for inflammatory bowel disease [IBD] remain controversial. The aim of our study was to compare postoperative morbidity of IBD surgery following treatment with VEDO vs other biologics or no biologics. An institutional review board-approved, prospectively collected...
Pierre, Nicolas Salée, Catherine Massot, Charlotte Blétard, Noëlla Mazzucchelli, Gabriel Smargiasso, Nicolas Morsa, Denis Baiwir, Dominique De Pauw, Edwin Reenaers, Catherine
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Published in
Journal of Crohn's & colitis
Based on genetics and natural history, Crohn's disease can be separated into two entities, an ileal and a colonic disease. Protein-based approaches are needed to elucidate whether such subphenotypes are related to distinct pathophysiological processes. The proteome of ulcer edges was compared with that of paired control tissue samples [n = 32 biops...
Agrawal, Manasi Burisch, Johan Colombel, Jean-Frederic C Shah, Shailja
Published in
Journal of Crohn's & colitis
The inflammatory bowel diseases [IBDs], inclusive of Crohn's disease [CD] and ulcerative colitis [UC], are chronic, progressive immune-mediated diseases associated with high morbidity and substantial economic impact. The pathogenesis implicates a complex interaction between environmental determinants and genetic susceptibility. Of concern, the inci...
Costa-Moreira, Pedro Lopes, Susana Santos, Ana Luísa Pedrosa, Ana Filipa Andrade, Patrícia Portugal, Raquel Macedo, Guilherme
Published in
Journal of Crohn's & colitis
Leukocytoclastic vasculitis is a single-organ, skin-isolated small vessel vasculitis. It can be a side effect of many common drugs, including biological agents. Unlike with other drugs, leukocytoclastic vasculitis induced by biological agents may have a prolonged latency period. We report the first case of ustekinumab-induced leukocytoclastic vascu...
Li, Tao Wang, Chunxu Liu, Yingmiao Li, Baorong Zhang, Wujian Wang, Lixiu Yu, Muxin Zhao, Xinyi Du, Jingwen Zhang, Jinming
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Published in
Journal of Crohn's & colitis
Despite the presence of neutrophil extracellular traps [NETs] in inflamed colon having been confirmed, the role of NETs, especially the circulating NETs, in the progression and thrombotic tendency of inflammatory bowel disease [IBD] remains elusive. We extended our previous study to prove that NETs constitute a central component in the progression ...
Chateau, Thomas Bonovas, Stefanos Le Berre, Catherine Mathieu, Nicolas Danese, Silvio Peyrin-Biroulet, Laurent
Published in
Journal of Crohn's & colitis
We aimed to summarize existing data on the effectiveness of vedolizumab in extra-intestinal manifestations [EIMs] in inflammatory bowel disease [IBD]. We conducted a systematic literature search in PubMed and the Cochrane Library, up to October 2018. Interventional and non-interventional studies as well as case-series studying vedolizumab and EIMs ...
Caprino, Paola Sacchett, Franco Sofo, Luigi
Published in
Journal of Crohn's & colitis
Alrubaiy, Laith Cheung, Wai-Yee Dodds, Phedra Hutchings, Hayley Anne Russell, Ian Trevor Watkins, Alan Williams, John Gordon
Published in
Journal of Crohn's & colitis
Mark-Christensen, Anders Erichsen, Rune Veres, Katalin Laurberg, Søren Sørensen, Henrik Toft
Published in
Journal of Crohn's & colitis
Patients with inflammatory bowel disease are at increased risk of extracolonic cancers. Little is known about this risk following total colectomy (TC). Patients who underwent TC for inflammatory bowel disease in Denmark during 1977-2013 were identified from the Danish National Patient Registry. Incidence rates of extracolonic cancers were determine...
