Kassis, Elias Baedorf Schaefer, Maximilian S. Maley, Jason H. Hoenig, Ben Loo, Ying Hayes, Margaret M. Moskowitz, Ari Talmor, Daniel
Published in
Journal of Critical Care
Purpose Acute Respiratory Distress Syndrome (ARDS) secondary to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has demonstrated variable oxygenation and respiratory-system mechanics without investigation of transpulmonary and chest-wall mechanics. This case series describes lung, chest wall and respiratory-system mechanics in patients...
Cuvelier, Clémence Fassier, Thomas Dalex, Meddy Lagrue, Simon Trombert, Véronique Herrmann, François R. Zekry, Dina Roux, Xavier
Published in
Journal of Critical Care
Di Mario, Francesca Regolisti, Giuseppe Di Maria, Alessio Parmigiani, Alice Benigno, Giuseppe Daniele Picetti, Edoardo Barbagallo, Maria Greco, Paolo Maccari, Caterina Fiaccadori, Enrico
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Published in
Journal of Critical Care
Acute Kidney Injury (AKI) is a frequent complication in critically ill patients with Coronavirus disease 2019 (COVID-19), and it has been associated with worse clinical outcomes, especially when Kidney Replacement Therapy (KRT) is required. A condition of hypercoagulability has been frequently reported in COVID-19 patients, and this very fact may c...
dos Reis Ururahy, Raul Park, Marcelo
Published in
Journal of Critical Care
Purpose The pathophysiology theories of COVID-19 attach the injury of target organs to faulty immune responses and occasionally hyper-inflammation. The damage frequently extends beyond the respiratory system, accompanying cardiovascular, renal, central nervous system, and/or coagulation derangements. Tumor necrosis factor-α (TNF-α) and interleukins...
Cruces, Pablo Cores, Camila Casanova, Daniel Pizarro, Federico Díaz, Franco
Published in
Journal of Critical Care
Background COVID-19 is a disease associated with an intense systemic inflammation that could induce severe acute respiratory distress syndrome (ARDS), with life-threatening hypoxia and hypercapnia. We present a case where mild therapeutic hypothermia was associated with improved gas exchange, facing other therapies' unavailability due to the pandem...
Arulkumaran, N. Green, J. Khan, A. Bonnici, T. Longobardo, A. Singer, M.
Published in
Journal of Critical Care
It remains unclear if intubation and ventilation earlier in the disease course confers a survival advantage in acute respiratory distress syndrome. Our objective was to determine whether patients with COVID-19 who died following mechanical ventilation were more advanced in their disease compared to survivors. Forty-seven patients admitted directly ...
Fisher, Richard Clarke, Jonathan Al-Arfi, Khaled Saha, Rohit Lioudaki, Eirini Mehta, Reena Pahl, Clemens Sharpe, Claire Bramham, Kate Hutchings, Sam
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Published in
Journal of Critical Care
• AKI frequently complicates COVID-19 in patients admitted to ICU. • Large numbers of patients and high rates of AKI leads to great demand for RRT. • In selected patients PD and IHD can supplement CRRT in meeting this demand. • PD and IHD can be implemented rapidly and safely through a collaborative approach.
Saban, Mor Reznik, Anna Shachar, Tal Wilf-Miron, Rachel Sivan-Hoffmann, Rotem
Published in
Journal of Critical Care
• Anecdotal reports on patients avoiding urgent care duringthe COVID-19 pandemic, have been increasingly documented. • A 41% decrease was noted during January-April 2020 in the number of patients admitted with suspected AIS, compared with 2019. • We found an increase of proportion of patients arriving within 6 h of symptoms onset compared with prev...
Hittesdorf, Erin Panzer, Oliver Wang, David Stevens, Jacob S Hastie, Jonathan Jordan, Desmond A Yoh, Nina Eiseman, Katherine A Elisman, Katerina Wagener, Gebhard
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Published in
Journal of critical care
COVID-19 has created an enormous health crisis and this spring New York City had a severe outbreak that pushed health and critical care resources to the limit. A lack of adequate space for mechanically ventilated patients induced our hospital to convert operating rooms into critical care areas (OR-ICU). A large number of COVID-19 will develop acute...
Ebm, Claudia Carfagna, Fabio Edwards, Sarah Mantovani, Alberto Cecconi, Maurizio
Published in
Journal of critical care
Despite growing controversies around Hydroxychloroquine's effectiveness, the drug is still widely prescribed by clinicians to treat COVID19 patients. Therapeutic judgment under uncertainty and imperfect information may be influenced by personal preference, whereby individuals, to confirm a-priori beliefs, may propose drugs without knowing the clini...