Shen, Andrew M Malekshah, Obeid M Pogrebnyak, Natalia Minko, Tamara
Published in
Journal of controlled release : official journal of the Controlled Release Society
Data show a decrease in the risk of hospitalization and death from COVID-19. To date, global vaccinations for SARS-CoV-2 protections are underway, but additional treatments are urgently needed to prevent and cure infection among naïve and even vaccinated people. Neutralizing monoclonal antibodies are very promising for prophylaxis and therapy of SA...
Homaeigohar, Shahin Liu, Xuan Elbahri, Mady
Published in
Journal of Controlled Release
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Meulewaeter, Sofie Nuytten, Gust Cheng, Miffy H Y De Smedt, Stefaan C Cullis, Pieter R De Beer, Thomas Lentacker, Ine Verbeke, Rein
Published in
Journal of controlled release : official journal of the Controlled Release Society
Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines currently require storage at deep freeze temperatures which complicates their storage and distribution, and ultimately leads to lower accessibility to low- and middle-income countrie...
Seow, Han Cong Cai, Jian-Piao Pan, Harry Weijie Luo, Cuiting Wen, Kun Situ, Jianwen Wang, Kun Cao, Hehe Leung, Susan W.S. Yuan, Shuofeng
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Journal of Controlled Release
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Domingues, Inês Michalowski, Cecilia Bohns Marotti, Valentina Zhang, Wunan Van Hul, Matthias Cani, Patrice D Leclercq, Isabelle A Beloqui, Ana
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Journal of controlled release : official journal of the Controlled Release Society
Non-alcoholic fatty liver disease (NAFLD) affects approximately 25% of the global adult population and can progress to end-stage liver disease with life-threatening complications; however, no pharmacologic therapy has been approved. Drug delivery systems such as lipid nanocapsules (LNCs) are a very versatile platform, easy to produce, and can induc...
He, Xiyue Chen, Xiaoyan Wang, Hairui Du, Guangsheng Sun, Xun
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Journal of Controlled Release
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Wen, Yu Zhang, Ru-Yan Wang, Jian Zhou, Shi-Hao Peng, Xiao-Qian Ding, Dong Zhang, Zhi-Ming Wei, Hua-Wei Guo, Jun
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Journal of Controlled Release
A new conjugating strategy was developed to construct effective self-adjuvanting protein vaccines through sialoglycoconjugation. The resulting adjuvant-glycoprotein conjugate (TLR7a-S1) induced effective anti-virus humoral and cellular immunity. Unlabelled Image
Bavli, Yaelle Chen, Bing-Mae Gross, Guy Hershko, Alon Turjeman, Keren Roffler, Steve Barenholz, Yechezkel
Published in
Journal of Controlled Release
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Winkeljann, Benjamin Keul, David C Merkel, Olivia M
Published in
Journal of controlled release : official journal of the Controlled Release Society
For the longest time, the field of nucleic acid delivery has remained skeptical whether or not polycationic drug carrier systems would ever make it into clinical practice. Yet, with the disclosure of patents on polyethyleneimine-based RNA carriers through leading companies in the field of nucleic acid therapeutics such as BioNTech SE and the progre...
Hirsch, Shira Hinden, Liad Naim, Meital Ben-David Baraghithy, Saja Permyakova, Anna Azar, Shahar Nasser, Taher Portnoy, Emma Agbaria, Majd Nemirovski, Alina
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Published in
Journal of controlled release : official journal of the Controlled Release Society
Over-activation of the endocannabinoid/CB1R system is a hallmark feature of obesity and its related comorbidities, most notably type 2 diabetes (T2D), and non-alcoholic fatty liver disease (NAFLD). Although the use of drugs that widely block the CB1R was found to be highly effective in treating all metabolic abnormalities associated with obesity, t...