Smithgall, Marie C. Scherberkova, Ioana Whittier, Susan Green, Daniel A.
Published in
Journal of Clinical Virology
Background The SARS-CoV-2 pandemic has created an urgent and unprecedented need for rapid large-scale diagnostic testing to inform timely patient management. However, robust data are lacking on the relative performance of available rapid molecular tests across a full range of viral concentrations. Objective This study aimed to compare two recently-...
Korth, Johannes Wilde, Benjamin Dolff, Sebastian Anastasiou, Olympia E. Krawczyk, Adalbert Jahn, Michael Cordes, Sebastian Ross, Birgit Esser, Stefan Lindemann, Monika
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Published in
Journal of Clinical Virology
Background The novel coronavirus SARS-CoV-2 is associated with a severe respiratory manifestation, COVID-19, and presents a challenge for healthcare systems worldwide. Healthcare workers are a vulnerable cohort for SARS-CoV-2 infection due to frequent and close contact to patients with COVID-19. Study design Serum samples from 316 healthcare worker...
LeBlanc, Jason J. Gubbay, Jonathan B. Li, Yan Needle, Robert Arneson, Sandra Radons Marcino, Dionne Charest, Hugues Desnoyers, Guillaume Dust, Kerry Fattouh, Ramzi
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Published in
Journal of Clinical Virology
With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. This study compared laboratory-developed tests (LDTs) used for the detection of SARS-CoV-2 in Canadian hospital and public health laboratories, and some commercially available real-time RT-PCR assays. Overall, analytical sensitivities were equivalent between LD...
Reuben, Rine Christopher Danladi, Margaret M.A. Pennap, Grace Rinmecit
Published in
Journal of Clinical Virology
With the COVID-19 officially declared a pandemic, Nigeria alongside other countries is directing all its resources and manpower to contain this pandemic. However, the existence of Lassa fever (LF), a more severe, zoonotic, endemic and viral haemorrhagic fever caused by Lassa virus with higher case fatality ratio (CFR) rages on across Nigeria while ...
Sun, Liping Liu, Gang Song, Fengxiang Shi, Nannan Liu, Fengjun Li, Shenyang Li, Ping Zhang, Weihan Jiang, Xiao Zhang, Yongbin
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Published in
Journal of Clinical Virology
Background Despite the death rate of COVID-19 is less than 3%, the fatality rate of severe/critical cases is high, according to World Health Organization (WHO). Thus, screening the severe/critical cases before symptom occurs effectively saves medical resources. Methods and materials In this study, all 336 cases of patients infected COVID-19 in Shan...
Perchetti, Garrett A. Nalla, Arun K. Huang, Meei-Li Zhu, Haiying Wei, Yulun Stensland, Larry Loprieno, Michelle A. Jerome, Keith R. Greninger, Alexander L.
Published in
Journal of Clinical Virology
Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused considerable disruption across the world, resulting in more than 235,000 deaths since December 2019. SARS-CoV-2 has a wide tropism and detection of the virus has been described in multiple specimen types, including various respiratory secretions, cerebrospinal fluid,...
Wolters, Femke de Bovenkamp, Jeroen van den Bosch, Bart van den Brink, Sharon van Broeders, Maaike Chung, Ngoc Hoa Favié, Barbara Goderski, Gabriel Kuijpers, Judith Overdevest, Ilse
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Published in
Journal of Clinical Virology
Background With the outbreak of SARS-CoV-2, rapid diagnostics are paramount to contain the current pandemic. The routinely used realtime RT-PCR is sensitive, specific and able to process large batches of samples. However, turnaround time is long and in cases where fast obtained results are critical, molecular point of care tests (POCT) can be an al...
Bulterys, Philip L. Garamani, Natasha Stevens, Bryan Sahoo, Malaya K. Huang, ChunHong Hogan, Catherine A. Zehnder, James Pinsky, Benjamin A.
Published in
Journal of Clinical Virology
Background Numerous nucleic acid amplification tests, including real-time, reverse transcription PCR (rRT-PCR) and isothermal amplification methods, have been developed to detect SARS-CoV-2 RNA, including many that have received emergency use authorization (EUA). There is a need to assess their test performance relative to one another. Objectives T...
van Kasteren, Puck B. van der Veer, Bas van den Brink, Sharon Wijsman, Lisa de Jonge, Jørgen van den Brandt, Annemarie Molenkamp, Richard Reusken, Chantal B.E.M. Meijer, Adam
Published in
Journal of Clinical Virology
The final months of 2019 witnessed the emergence of a novel coronavirus in the human population. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has since spread across the globe and is posing a major burden on society. Measures taken to reduce its spread critically depend on timely and accurate identification of virus-infected individ...
Mustafa, Naira M A Selim, Laila
Published in
Journal of Clinical Virology
Background Coronavirus disease 2019 (COVID-19) is a pandemic first originated in Wuhan the capital of Hubei province, China in December 2019 and then spread globally. It is caused by SARS-CoV-2. Until 1 April 2020, the number of cases worldwide was recorded to be 823,626 with 40,598 deaths. Most of the reported cases were adults with few cases desc...
