Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Although the clinical course of the COVID-19 in adults has been extensively described, the impact of the co-detection of SARS-CoV-2 and rhinovirus on severity outcomes is not understood. This study aimed to compare the risk of hospitalization of outpatients with COVID-19 with and without the co-detection of rhinovirus in southern Brazil. Secondaril...
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Viral respiratory infections are common in children, and usually associated with non-specific symptoms. Respiratory panel-based testing was implemented during the COVID-19 pandemic, for the rapid differentiation between SARS-CoV-2 and other viral infections, in children attending the emergency department (ED) of the teaching hospital of Lille, nort...
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
The SARS-CoV-2 pandemic has resulted in massive testing by Rapid Antigen Tests (RAT) without solid independent data regarding clinical performance being available. Thus, decision on purchase of a specific RAT may rely on manufacturer-provided data and limited peer-reviewed data. This study consists of two parts. In the retrospective analytical part...
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
SARS-CoV-2 viral load and kinetics assessed in serial blood samples from hospitalised COVID-19 patients by RT-PCR are poorly understood. We conducted an observational, prospective case series study in hospitalised COVID-19 patients. Clinical outcome data (Intensive Care Unit admission and mortality) were collected from all patients until discharge....
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
The virus neutralization test (VNT) is the reference for the assessment of the functional ability of neutralizing antibodies (NAb) to block SARS-CoV-2 entry into cells. New competitive immunoassays measuring antibodies preventing interaction between the spike protein and its cellular receptor are proposed as surrogate VNT (sVNT). We tested three co...
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Knowing how long SARS-CoV-2-positive individuals can remain infective is crucial for the design of infection prevention and control strategies. Viral culture is the gold standard for detecting an active-replicative virus and evaluating its infectious potential. To assess the correlation of SARS-CoV-2 infectivity with the number of days from symptom...
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
The aim of this study was to develop a RT-PCR assay for the specific detection of the SARS-CoV-2 Omicron Variant of Concern (VOC) as a rapid alternative to sequencing. A RT-PCR was designed in silico and then validated using characterised clinical samples containing Omicron (both BA.1 and BA.2 lineages) and the Omicron synthetic RNA genome. As nega...
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
The mRNA Covid-19 vaccine (BNT162b2) is administered in two doses with 21 days interval. On 4th October 2021 European Medicines Agency approved administration of a booster dose in at least 6 months after the second dose for people aged 18 years and older. In the present study we compare the anti-SARS-COV-2 IgG and IgA antibody responses post comple...
