Richman, Susan D Hemmings, Gemma Roberts, Helen Gallop, Niall Dodds, Rachel Wilkinson, Lyndsay Davis, Jonathan White, Rhian Yates, Emma Jasani, Bharat
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Published in
Journal of clinical pathology
FOCUS4 was a phase II/III umbrella trial, recruiting patients with advanced or metastatic colorectal cancer, between 2014 and 2020. Molecular profiling of patients' formalin-fixed, paraffin-embedded tumour blocks was undertaken at two centralised biomarker laboratories (Leeds and Cardiff), and the results fed directly to the Medical Research Counci...
Pell, Robert Suvarna, S Kim Cooper, Nigel Rutty, Guy Green, Anna Osborn, Michael Johnson, Peter Hayward, Alison Durno, Justine Estrin-Serlui, Theodore
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Published in
Journal of clinical pathology
Widespread disruption of healthcare services and excess mortality not directly attributed to COVID-19 occurred between March and May 2020. We undertook the first UK multicentre study of coroners' autopsies before and during this period using postmortem reports. We reviewed reports of non-forensic coroners' autopsies performed during the first COVID...
van Rooyen, Cathrine Brauer, Marieke Swanepoel, Petri van den Berg, Sylvia van der Merwe, Cassandre van der Merwe, Marischa Green, Robin Becker, Piet
Published in
Journal of clinical pathology
To compare specific T-cell responses between laboratory employees in South Africa with and without previously diagnosed SARS-CoV-2 infection. Employees at a private pathology laboratory in South Africa were invited to participate in a nationwide cross-sectional study. T-cell proliferation to SARS-CoV-2 nucleocapsid (N)-proteins and spike (S)-protei...
Moore, Nathan Williams, Rebecca Mori, Matilde Bertolusso, Beatrice Vernet, Gabrielle Lynch, Jessica Philipson, Pete Ledgerwood, Thomas Kidd, Stephen P Thomas, Claire
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Published in
Journal of clinical pathology
There is a lack of biomarkers validated for assessing clinical deterioration in patients with COVID-19 on presentation to secondary or tertiary care. This evaluation looked at the potential clinical application of C reactive protein (CRP), procalcitonin, mid-regional proadrenomedullin (MR-proADM) and white cell count to support prediction of clinic...
Elghobashy, Mirna Wahab, Lutful Gunavardhan, Anu O'Sullivan, Emma Provenzano, Elena Deb, Rahul Pritchard, Susan Di Palma, Silvana Ellis, Ian O Boyd, Clinton
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Published in
Journal of clinical pathology
There is little information on the impact of COVID-19 on breast pathologists. This survey assessed the effect of the COVID-19 pandemic on UK and Ireland-based breast pathologists to optimise working environments and ensure preparedness for potential future pandemics. A 35-question survey during the first wave of COVID-19 infections in the UK includ...
Holland, David Heald, Adrian H Stedman, Mike Hanna, Fahmy Wu, Pensee Duff, Christopher Green, Lewis Robinson, Sarah Halsall, Ian Gaskell, Neil
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Published in
Journal of clinical pathology
The COVID-19 pandemic, and the focus on mitigating its effects, has disrupted diabetes healthcare services worldwide. We aimed to quantify the effect of the pandemic on diabetes diagnosis/management, using glycated haemoglobin (HbA1c) as surrogate, across six UK centres. Using routinely collected laboratory data, we estimated the number of missed H...
Estrin-Serlui, Theodore Osborn, Michael
Published in
Journal of clinical pathology
The aim of this study is to evaluate whether there has been a significant change in the frequency of markedly decomposed bodies having coronial autopsies since the UK's first COVID-19 lockdown. We compared coronial autopsies (n=263) performed by one pathologist at a central London mortuary in the 1 year before and after 23 March 2020 by analysing t...
Ye, Shan Wu, Jing Yao, Lingli He, Jie
Published in
Journal of clinical pathology
To investigate the clinicopathological and molecular characteristics of uterine tumours resembling ovarian sex cord tumours (UTROSCTs) and the value of molecular diversity in the clinical diagnosis and treatment. Five patients with UTROSCT were enrolled, and their clinical data, pathological morphologies, immunophenotypes and molecular features wer...
Tabasaran, Julian Schuhmann, Martin Ebinger, Martin Honegger, Jürgen Renovanz, Mirjam Schittenhelm, Jens
Published in
Journal of clinical pathology
An ependymoma shows divergent morphological and molecular features depending on their location. The paired box 6 (PAX6) transcription factor is a putative tumour suppressor and drives cancer cells towards a stem cell-like state. A transcriptome study reported high PAX6 expression in ependymal tumours, but data on protein expression are lacking. We,...
Taylor, David R Buchanan, Devon Al-Hasani, Wiaam Kearney, Jessica Mazaheri, Tina Ranasinghe, Ruvini N K Dimitriadis, Georgios K Vincent, Royce P
Published in
Journal of Clinical Pathology
Aims Public Health England has identified that in COVID-19, death rates among ethnic minorities far exceeds that of the white population. While the increase in ethnic minorities is likely to be multifactorial, to date, no studies have looked to see whether values for routine clinical biochemistry parameters differ between ethnic minority and white ...
