The Brief Case: An unexpected cause of meningoencephalitis in an infant
Published in Journal of Clinical Microbiology
The Brief Case: An unexpected cause of meningoencephalitis in an infant
Photo Quiz: Unexpected finding in a Gram stain
Published in Journal of Clinical Microbiology
Answer to the Photo Quiz: Unexpected finding in a Gram stain
Published in Journal of Clinical Microbiology
Development of simple, rapid, and sensitive methods for detection of hepatitis C virus RNA from whole blood using revers...
Published in Journal of Clinical Microbiology
Hepatitis C virus (HCV) infection is an underdiagnosed global health problem. Diagnosis of current HCV infections typically requires testing for HCV RNA using high-complexity laboratory tests. Methods for the detection of HCV RNA that are simple, inexpensive, rapid, and compatible with use outside of a laboratory setting are very important in order...
QIAstat-Dx gastrointestinal panel and Luminex xTAG gastrointestinal pathogen panel comparative evaluation
Published in Journal of Clinical Microbiology
The diagnosis of acute gastroenteritis is an ongoing clinical challenge in terms of identification of the etiologic agent, time to results, and appropriate treatment. Rapid detection of gastrointestinal pathogens is needed to improve patient care. This study evaluates the performance of the QIAstat-Dx gastrointestinal panel (Q-GP; Investigational U...
Evaluation of the Cepheid 3-gene host response blood test for tuberculosis diagnosis and treatment response monitoring i...
...Published in Journal of Clinical Microbiology
A rapid, accurate, non-sputum-based triage test for diagnosing tuberculosis (TB) is a high-priority need. Cepheid developed a novel prototype blood test, Xpert Mycobacterium tuberculosis Host Response (Xpert-MTB-HR), which generates a TB score based on the mRNA expression of three genes. We conducted a case-control study with prospective recruitmen...
Multi-center clinical evaluation of the Panther Fusion SARS-CoV-2/Flu A/B/RSV assay in nasopharyngeal swab specimens fro...
...
Published in Journal of Clinical Microbiology
The symptomology is overlapping for respiratory infections due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), influenza A/B viruses, and respiratory syncytial virus (RSV). Accurate detection is essential for proper medical management decisions. This study evaluated the clinical performance of the Panther Fusion SARS-CoV-2/Flu A/B/...
Complex norovirus transmission dynamics at hospital wards revealed by deep sequencing
Published in Journal of Clinical Microbiology
Detailed knowledge regarding norovirus transmission within hospitals is limited. We investigated a norovirus hospital outbreak affecting 65 patients at five different wards. PCR showed that 61 (94%) of the patients were infected with genotype II.4 strains. Successful Ion Torrent deep sequencing of GII.4 positive samples from 59 patients followed by...
Valid and accepted novel bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2022
Published in Journal of Clinical Microbiology
Although some nomenclature changes have caused consternation among clinical microbiologists, the discovery of novel taxa and improving classification of existing groups of organisms is exciting and adds to our understanding of microbial pathogenesis. In this mini-review, we present an in-depth summary of novel taxonomic designations and revisions t...
Use of genome sequencing to resolve differences in gradient diffusion and agar dilution antimicrobial susceptibility tes...
Published in Journal of Clinical Microbiology
Agar dilution is the gold standard method for phenotypic antimicrobial susceptibility testing (AST) for Neisseria gonorrhoeae. However, this method is laborious and requires expertise, so laboratories that perform N. gonorrhoeae AST may choose alternative methods such as disk diffusion and gradient diffusion. In this study, we retrospectively compa...
