Protein kinase N1 critically regulates cerebellar development and long-term function
...Published in Journal of Clinical Investigation
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
...Published in Journal of Clinical Investigation
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
...Published in Journal of Clinical Investigation
Mutations in sphingosine-1-phosphase lyase cause nephrosis with ichthyosis and adrenal insufficiency
...Published in Journal of Clinical Investigation
Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases. A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of individuals with SRNS whose symptoms manifest before 25 years of age. However, in many patients, the genetic etiology remains unknown. Here, we have performed whole exome sequenci...
Characterization of pandemic influenza immune memory signature after vaccination or infection.
...Published in Journal of Clinical Investigation
The magnitude, quality, and maintenance of immunological memory after infection or vaccination must be considered for future design of effective influenza vaccines. In 2009, the influenza pandemic produced disease that ranged from mild to severe, even fatal, illness in infected healthy adults and led to vaccination of a portion of the population wi...
CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance.
...Published in Journal of Clinical Investigation
The majority of non-small cell lung cancer (NSCLC) patients harbor EGFR-activating mutations that can be therapeutically targeted by EGFR tyrosine kinase inhibitors (EGFR-TKI), such as erlotinib and gefitinib. Unfortunately, a subset of patients with EGFR mutations are refractory to EGFR-TKIs. Resistance to EGFR inhibitors reportedly involves SRC a...
SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas.
...Published in The Journal of clinical investigation
The transcription factor SOX2 is an essential regulator of pluripotent stem cells and promotes development and maintenance of squamous epithelia. We previously reported that SOX2 is an oncogene and subject to highly recurrent genomic amplification in squamous cell carcinomas (SCCs). Here, we have further characterized the function of SOX2 in SCC. U...
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.
...Published in Journal of Clinical Investigation
Metabolic profiling of cancer cells has recently been established as a promising tool for the development of therapies and identification of cancer biomarkers. Here we characterized the metabolomic profile of human breast tumors and uncovered intrinsic metabolite signatures in these tumors using an untargeted discovery approach and validation of ke...
LRH-1-dependent glucose sensing determines intermediary metabolism in liver.
...Published in Journal of Clinical Investigation
Liver receptor homolog 1 (LRH-1), an established regulator of cholesterol and bile acid homeostasis, has recently emerged as a potential drug target for liver disease. Although LRH-1 activation may protect the liver against diet-induced steatosis and insulin resistance, little is known about how LRH-1 controls hepatic glucose and fatty acid metabol...
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors....
Published in Journal of Clinical Investigation
Appropriate localization and migration of T cells is a prerequisite for antitumor immune surveillance. Studies using fixed tumor samples from human patients have shown that T cells accumulate more efficiently in the stroma than in tumor islets, but the mechanisms by which this occurs are unknown. By combining immunostaining and real-time imaging in...
