Mizunashi, K Furukawa, Y Miura, R Yumita, S Sohn, H E Yoshinaga, K
Published in
The Journal of clinical investigation
Serum osteocalcin was measured in patients with idiopathic hypoparathyroidism or pseudohypoparathyroidism, before or during the treatment with active vitamin D3 (1,25(OH)2D3 or 1 alpha OHD3). Serum osteocalcin and plasma 1,25(OH)2D were decreased in 11 patients with idiopathic hypoparathyroidism before treatment (2.8 +/- 1.27 ng/ml, P less than 0.0...
Nedden, Stephanie zur Eith, Rafaela Schwarzer, Christoph Zanetti, Lucia Seitter, Hartwig Fresser, Friedrich Koschak, Alexandra Cameron, Angus J.M. Parker, Peter J. Baier, Gottfried
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Published in
Journal of Clinical Investigation
Zohar, Yaniv Wildbaum, Gizi Novak, Rostislav Salzman, Andrew L. Thelen, Marcus Alon, Ronen Barsheshet, Yiftah Karp, Christopher L. Karin, Nathan Willow Creek Capital Partners, L.P.
...
Published in
Journal of Clinical Investigation
Softic, Samir Gupta, Manoj K. Wang, Guo-Xiao Fujisaka, Shiho O’Neill, Brian T. Rao, Tata Nageswara Willoughby, Jennifer Harbison, Carole Fitzgerald, Kevin Ilkayeva, Olga
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Published in
Journal of Clinical Investigation
Lovric, Svjetlana Goncalves, Sara Gee, Heon Yung Oskouian, Babak Srinivas, Honnappa Choi, Won-Il Shril, Shirlee Ashraf, Shazia Tan, Weizhen Rao, Jia
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Published in
Journal of Clinical Investigation
Steroid-resistant nephrotic syndrome (SRNS) causes 15% of chronic kidney disease cases. A mutation in 1 of over 40 monogenic genes can be detected in approximately 30% of individuals with SRNS whose symptoms manifest before 25 years of age. However, in many patients, the genetic etiology remains unknown. Here, we have performed whole exome sequenci...
Millet, Arnaud Martin, Katherine R. Bonnefoy, Francis Saas, Philippe Mocek, Julie Alkan, Manal Terrier, Benjamin Kerstein, Anja Tamassia, Nicola Satyanarayanan, Senthil Kumaran
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Published in
Journal of Clinical Investigation
Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis that is associated with granulomatous inflammation and the presence of anti-neutrophil cytoplasmic antibodies (ANCAs) directed against proteinase 3 (PR3). We previously determined that PR3 on the surface of apoptotic neutrophils interferes with induction of antiinflammatory...
Um, Sung Hee Sticker-Jantscheff, Melanie Chau, Gia Cac Vintersten, Kristina Mueller, Matthias Gangloff, Yann-Gael Adams, Ralf H Spetz, Jean-Francois Elghazi, Lynda Pfluger, Paul T
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Published in
Journal of Clinical Investigation
Type 2 diabetes mellitus (T2DM) is a worldwide heath problem that is characterized by insulin resistance and the eventual loss of β cell function. As recent studies have shown that loss of ribosomal protein (RP) S6 kinase 1 (S6K1) increases systemic insulin sensitivity, S6K1 inhibitors are being pursued as potential agents for improving insulin res...
Magalhaes, Isabelle Pingris, Karine Poitou, Christine Bessoles, Stéphanie Venteclef, Nicolas Kiaf, Badr Beaudoin, Lucie Da Silva, Jennifer Allatif, Omran Rossjohn, Jamie
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Published in
Journal of Clinical Investigation
Obesity and type 2 diabetes (T2D) are associated with low-grade inflammation, activation of immune cells, and alterations of the gut microbiota. Mucosal-associated invariant T (MAIT) cells, which are innate-like T cells that recognize bacterial ligands, are present in blood and enriched in mucosal and inflamed tissues. Here, we analyzed MAIT cells ...
Bonduelle, Olivia Carrat, Fabrice Luyt, Charles-Edouard Leport, Catherine Mosnier, Anne Benhabiles, Nora Krivine, Anne Rozenberg, Flore Yahia, Nora Samri, Assia
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Published in
Journal of Clinical Investigation
The magnitude, quality, and maintenance of immunological memory after infection or vaccination must be considered for future design of effective influenza vaccines. In 2009, the influenza pandemic produced disease that ranged from mild to severe, even fatal, illness in infected healthy adults and led to vaccination of a portion of the population wi...
Park, Kang-Seo Raffeld, Mark Moon, Yong Wha Xi, Liqiang Bianco, Caterina Pham, Trung Lee, Liam C Mitsudomi, Tetsuya Yatabe, Yasushi Okamoto, Isamu
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Published in
Journal of Clinical Investigation
The majority of non-small cell lung cancer (NSCLC) patients harbor EGFR-activating mutations that can be therapeutically targeted by EGFR tyrosine kinase inhibitors (EGFR-TKI), such as erlotinib and gefitinib. Unfortunately, a subset of patients with EGFR mutations are refractory to EGFR-TKIs. Resistance to EGFR inhibitors reportedly involves SRC a...
