Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells
...Published in Journal of Cellular Physiology
AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Re...
...Published in Journal of Cellular Physiology
cAMP and cGMP Play an Essential Role in Galvanotaxis of Cell Fragments.
Published in Journal of cellular physiology
Cell fragments devoid of the nucleus and major organelles are found in physiology and pathology, for example platelets derived from megakaryocytes, and cell fragments from white blood cells and glioma cells. Platelets exhibit active chemotaxis. Fragments from white blood cells display chemotaxis, phagocytosis, and bactericidal functions. Signaling ...
The role of electrical signals in murine corneal wound re-epithelialization.
Published in Journal of cellular physiology
Ion flow from intact tissue into epithelial wound sites results in lateral electric currents that may represent a major driver of wound healing cell migration. Use of applied electric fields (EF) to promote wound healing is the basis of Medicare-approved electric stimulation therapy. This study investigated the roles for EFs in wound re-epitheliali...
Stem Cell Antigen-1 Localizes to Lipid Microdomains and Associates With Insulin Degrading Enzyme in Skeletal Myoblasts
Published in Journal of Cellular Physiology
Stem cell antigen-1 (Sca-1, Ly6A/E) is a glycosylphosphotidylinositol-anchored protein that identifies many tissue progenitor cells. We originally identified Sca-1 as a marker of myogenic precursor cells and subsequently demonstrated that Sca-1 regulates proliferation of activated myoblasts, suggesting an important role for Sca-1 in skeletal muscle...
Increased mobilization of c-kit+ Sca-1+ Lin- (KSL) cells and colony-forming units in spleen (CFU-S) following de novo fo...
...Published in Journal of Cellular Physiology
Stem cells are thought to inhabit in a unique microenvironment, known as "niche," in which they undergo asymmetric cell divisions that results in reproducing both stem cells and progenies to maintain various tissues throughout life. The cells of osteoblastic lineage have been identified as a key participant in regulating the number of hematopoietic...
cDNA-array profiling of melanomas and paired melanocyte cultures.
...Published in Journal of Cellular Physiology
Three paired (from the same donor) sets of melanoma cells and normal melanocytes, established as early-passage cultures from metastatic lesions and the uninvolved skin of three patients, were comparatively cDNA profiled by macroarrays (approximately 1,200 genes) and reverse transcription (RT)-PCR. While 145 gene products were significantly (at leas...
Carbon dioxide efflux accompanies release of fertilization acid from sea urchin eggs.
Published in Journal of Cellular Physiology
"Fertilization acid" is released from sea urchin eggs upon fertilization and decreases the pH of the surrounding seawater. In bicarbonate-free artificial seawater flushed with nitrogen gas, the pH shift still occurs but returns to the original value in a few minutes, suggesting that the released acid volatile. A likely candidate for a volatile acid...
Intracellular pH changes during the cell cycle in Tetrahymena.
Published in Journal of Cellular Physiology
The equilibrium distribution of 5,5-dimethyloxazoladine 2,4-dione (DMO) between intra- and extracellular volume was used to estimate intracellular pH (pHi) in Tetrahymena pyiformis. In control experiments, DMO was found to equilibrate rapidly in response to a pH gradient. Under normal growth conditions, pHi was constant over a finite range of exter...
Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: evidence of an endogenous...
Published in Journal of Cellular Physiology
Wound healing is a complex and well-orchestrated biological process. Corneal epithelial cells (CECs) must respond quickly to trauma to rapidly restore barrier function and protect the eye from noxious agents. They express a high level of beta2-adrenergic receptors but their function is unknown. Here, we report the novel finding that they form part ...
