Published in Journal of Cell Science
Summary: The EMC is an important factor facilitating membrane protein biogenesis. Here we discuss the broad cellular and organismal responsibilities overseen by client proteins requiring the EMC for maturation.
Published in Journal of Cell Science
Summary: ADAMTS-1 and syndecan-4 collaborate to regulate cell adhesion, migration and integrin α5 trafficking, and to sequester VEGFA164, inhibiting angiogenesis.
Published in Journal of Cell Science
Highlighted Article: PTPN23 associates with BICD1 via its dynein-binding region, and its loss results in accumulation of neurotrophin receptors in enlarged, ubiquitylated sorting compartments.
Published in Journal of Cell Science
Summary: During Drosophila morphogenesis, the larval epithelial cells transit from migration to constriction. A change in the polarity of their pulsatile cytoskeletal network and tightly controlled cellular contractility underlie this transition.
Published in Journal of Cell Science
Highlighted Article: Lamin plays a role in post-translational modification of plasma membrane proteins by tethering the GPI modification enzyme PIG-B to the inner nuclear membrane.
Published in Journal of Cell Science
Summary: A discussion of the distinct host cell transport routes that underpin the biogenesis and function of plant–pathogen interfaces.
Published in Journal of Cell Science
Highlighted Article: Maintenance of centrosome cohesion is critical for the fidelity of cell division. Here, we show that the novel protein Cep44 plays a unique role in the cohesion process through stabilizing rootletin.
Published in Journal of Cell Science
Summary: GDE2, a six-transmembrane GPI-specific phospholipase, undergoes constitutive endosomal recycling via newly identified sequences and a unique leucine residue in its C-terminal tail as a way to regulate neuronal differentiation.
Published in Journal of Cell Science
Summary: Morgana, a Drosophila homologue of an oncogene, physically interacts with Hsp90 complexes and has an independent function in regulating microtubule polymerisation, both in vitro and in vivo .
Published in Journal of Cell Science
Summary: The adaptor proteins HAP1a and GRIP1 form a protein complex in the brain, and co-operate to activate the kinesin-1 subunit KIF5C in vitro .
