Published in Journal of Cell Science
Summary: Rab11a and Rab11b, as well their effector Sec15, are required for lysosome exocytosis, and the Rab3a guanine nucleotide exchange factor GRAB is essential for this process.
Published in Journal of Cell Science
Summary: Identification of cellular systems that impinge on protein homeostasis during arsenite stress in yeast, showing that transcriptional and translational control is central for mitigating protein aggregation and toxicity.
Published in Journal of Cell Science
Summary: Endocytic delivery to lysosomes by kiss and run/membrane fusion entails pore formation commencing at the edge of tether arrays, and demonstrates SNARE redundancy and compensation.
Published in Journal of Cell Science
Summary: The nuclear scaffold protein lamin A/C modulates nuclear stiffness, and heterogeneous lamin A/C density leads to diverse nuclear strain under stress.
Published in Journal of Cell Science
Summary: Recruitment of the host cell Golgi by the parasitophorous vacuolar membrane of Plasmodium berghei is crucial for optimal pre-erythrocytic development. The interaction is accompanied by parasite-induced formation of miniaturized host cell Golgi.
Published in Journal of Cell Science
Summary: An in-depth cellular and molecular characterization of myosin XIX (Myo19)-deficient cells reveals that different cellular and molecular processes are linked to mitochondrial dynamics regulated by Myo19.
Published in Journal of Cell Science
Summary: Fusion of monocytes to become bone-resorbing osteoclasts is limited by an SNX10-dependent cell-autonomous mechanism. Loss of SNX10 function deregulates fusion and generates giant inactive osteoclasts.
Published in Journal of Cell Science
Summary: The plasma membrane-associated Zdhhc5 enzyme enhances excitatory synapse formation in vitro and in vivo through motifs at its C-terminal domain.
Published in Journal of Cell Science
Summary: Mutagenic, expression and histological analyses reveal an essential role for miR-34b/c and miR-449 in multiciliogenesis in efferent ductules of the male reproductive tract by regulating cell cycle exit.
Published in Journal of Cell Science
Summary: Reduced protein synthesis is required for stem cell functions. Here, we delineate a complex interplay of polyamines and mRNA translation that determines hair follicle stem cell fate decisions.
