Microtubule-severing activity of AAA+ ATPase Katanin is essential for female meiotic spindle assembly
Published in Journal of Cell Science
Btn3 regulates the endosomal sorting function of the yeast Ent3 epsin, an adaptor for SNARE proteins
Published in Journal of Cell Science
Confluence switch signaling regulates ECM composition and the plasmin proteolytic cascade in keratinocytes.
...Published in Journal of Cell Science
In culture, cell confluence generates signals that commit actively growing keratinocytes to exit the cell cycle and differentiate to form a stratified epithelium. Using a comparative proteomic approach, we studied this 'confluence switch' and identified a new pathway triggered by cell confluence that regulates basement membrane (BM) protein composi...
Polycomb repressive complex 2 impedes intestinal cell terminal differentiation.
Published in Journal of Cell Science
The crypt-villus axis constitutes the functional unit of the small intestine, where mature absorptive cells are confined to the villi, and stem cells and transit amplifying and differentiating cells are restricted to the crypts. The polycomb group (PcG) proteins repress differentiation and promote self-renewal in embryonic stem cells. PcGs prevent ...
Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes.
Published in Journal of Cell Science
In Drosophila, the humoral response characterised by the synthesis of antimicrobial peptides (AMPs) in the fat body (the equivalent of the mammalian liver) and the cellular response mediated by haemocytes (blood cells) engaged in phagocytosis represent two major reactions that counter pathogens. Although considerable analysis has permitted the eluc...
Loss of desmocollin 3 in mice leads to epidermal blistering
Published in Journal of Cell Science
Summary Desmocollin 3 (DSC3) belongs to a subfamily of cadherins and is a major component of desmosomes in keratinocytes of stratified epithelia, such as the epidermis. Based on its amino acid sequence homology to classical cadherins, such as E-cadherin, it has been postulated that DSC3 functions as a cell-adhesion molecule. To test this hypothesis...
Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated ...
Published in Journal of Cell Science
The LOX-1 scavenger receptor recognises pro-atherogenic oxidised low-density lipoprotein (OxLDL) particles and is implicated in atherosclerotic plaque formation, but this mechanism is not well understood. Here we show evidence for a novel clathrin-independent and cytosolic-signal-dependent pathway that regulates LOX-1-mediated OxLDL internalisation...
Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5).
Published in Journal of Cell Science
The control of growth of lymphocyte populations is crucial to the physiological regulation of the immune system, and to the prevention of both leukaemic and autoimmune disease. This control is mediated through modulation of the cell cycle and regulation of cell death. During log-phase growth the rate of proliferation is high and there is a low rate...
The beta 2-adrenergic receptor activates pro-migratory and pro-proliferative pathways in dermal fibroblasts via divergen...
Published in Journal of Cell Science
Cyclic AMP mediates keratinocyte directional migration in an electric field
Published in Journal of Cell Science
