Tong, Jiaci Li, Haoran Hu, Ye Zhao, ZuoWei Li, Man
Published in
Journal of Cancer
Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer with high metastatic potential. To date, no directed treatment options have been developed for the treatment of metastatic or advanced TNBC. The oncogene TMEM158, also known as RIS1, is upregulated by Ras-induced cellular senescence. Although TMEM158 has been shown to...
Xie, Yandong Xiao, Yong Liu, Yuyang Lu, Xueying Wang, Zhen Sun, Shuo Liu, Liang Tang, Xianglong Xiao, Hong Liu, Hongyi
...
Published in
Journal of Cancer
Background: Gliomas are the most refractory intracranial disease characterized by high incidence and mortality rates. Therefore, radiotherapy plays a crucial role in the treatment of gliomas. However, recent evidence reveals that ferroptosis is highly associated with radiosensitivity in tumor cells. Therefore, this study aimed to investigate radios...
Liu, Yushu Gong, Jiantao Huang, Yanyi Xing, Shanshan Chen, Ling Yi, Tao Wang, Zhiyong Lv, Yunxia
Published in
Journal of Cancer
Background: Mostly current studies are limited to the impact of lymph node metastasis(LNM) on the prognosis of papillary thyroid cancer(PTC) or the impact of glucose metabolism on the occurrence of PTC, but no one has paid attention to the connection between fasting serum glucose(FSG) and LNM. The purpose of our study was to explore the relationshi...
Huang, Hua Zhu, Guangsheng Shi, Ruifeng Li, Yongwen Zhang, Zihe Xu, Songlin Chen, Chen Cao, Peijun Pan, Zhenhua Zhang, Hongbing
...
Published in
Journal of Cancer
Lung cancer is the leading cause of cancer-related deaths worldwide. Hypoxia is a crucial microenvironmental factor in lung adenocarcinoma (LUAD). However, the prognostic value based on hypoxia and immune in LUAD remains to be further clarified. The hypoxia-related genes (HRGs) and immune-related genes (IRGs) were downloaded from the public databas...
Xu, Fanfan Chen, Mengxia Chen, Hao Wu, Nan Qi, Qinqin Jiang, Xiujiao Fang, Daoquan Feng, Qian Jin, Rong Jiang, Lei
...
Published in
Journal of Cancer
Background: Our previous study has shown that Da0324, a curcumin analog, exhibited significantly improved stability and antitumor activity. However, the molecular mechanisms of action of Da0324 remain poorly understood. Long non-coding RNA (lncRNA) has been shown to play a key role in tumor progression. Here, we aim to investigate the molecular mec...
Zhang, Yamei Zhang, Yabo Zeng, Qianglin Li, Ci Zhou, Hui Liu, Junying Shi, Zheng Ma, Li
Published in
Journal of Cancer
Background: Long noncoding RNAs (LncRNAs) possess crucial roles in carcinogenesis. The current study aims to evaluate the effects of interleukin-1β (IL-1β)-mediated lncRNA cardiac hypertrophy-related factor (CHRF)/microRNA-489 (miR-489)/myeloid differentiation factor 88 (Myd88) on non-small-cell lung cancer (NSCLC). Methods: Initially, the expressi...
Godugu, Kavitha Karakus, Ozlem O Fujioka, Kazutoshi Glinsky, Gennadi V Mousa, Shaker A
Published in
Journal of Cancer
Background: In neuroendocrine tumors, the norepinephrine transporter (NET) is very active and has been exploited for diagnostic imaging purposes and/or therapy with localized radiotherapy. Integrin αvβ3 is generously expressed by and/or activated on cancer cells, but not by nonmalignant cells. Purpose: In the present investigation, the anticancer e...
Ma, Fayang Liu, Fangfang Nie, Wenna Laster, Kyle Tian, Xueli Lu, Bingbing Geng, Zushi Bai, Ruihua Kim, Dong Joon Liu, Kangdong
...
Published in
Journal of Cancer
Esophageal squamous cell carcinoma (ESCC) is a malignant cancer that is responsible for a high mortality rate; it accounts for approximately 90% of the 456,000 esophageal cancer (EC) cases diagnosed annually. Effective natural or synthesized compounds to prevent, treat, and/or inhibit ESCC relapse are desperately needed. The natural di-indole compo...
Ogawa, Keita Kanzaki, Hiroaki Chiba, Tetsuhiro Ao, Junjie Qiang, Na Ma, Yaojia Zhang, Jiaqi Yumita, Sae Ishino, Takamasa Unozawa, Hidemi
...
Published in
Journal of Cancer
Atezolizumab plus bevacizumab (ATZ/BV) treatment is a combined immunotherapy consisting of immune checkpoint inhibitor (ICI) and anti-vascular endothelial growth factor monoclonal antibody, which has brought a major paradigm shift in the treatment of unresectable hepatocellular carcinoma (HCC). Gain-of-function mutation of CTNNB1 contributes to res...
Huang, Shiqing Jin, Mingyang Lan, Xiaoling Wu, Junyun Long Zhang, Zhiwen Zhao, Jingjing Li, Yepeng
Published in
Journal of Cancer
Background: Long non-coding RNA (lncRNA) regulates the tumorigenesis as well as the development of lung adenocarcinoma (LUAD), which is one of the high-mortality cancers. We explored the influence of lncRNA AC098934 on the malignant biological behavior of LUAD and potential underlying molecular mechanisms. Methods: The expression level of AC098934 ...
