Mao, Lijun Yu, Haiyuan Ma, Sai Xu, Ziyang Wei, Fukun Yang, Chunhua Zheng, Junnian
Published in
Journal of Cancer
Background: Oncolytic viral therapy is a new strategy for tumor eradication which combines the advantages of viral therapy and gene therapy. Silencing SATB1 exhibits strong inhibitory effect on the growth of prostate cancer. Docetaxel (DTX) is the gold standard for chemotherapy of prostate cancer, but its side effects decrease the life quality of p...
Han, YaLi Yu, XiaQing Yin, YuZhen Lv, Zhongwei Jia, ChengYou Liao, Yina Sun, Hongyan Liu, Tie Cong, Lele Fei, ZhaoLiang
...
Published in
Journal of Cancer
As the most common mutation in papillary thyroid cancer (PTC), B-type Raf kinase V600E mutation ( BRAF V600E ) has become an important target for the clinical treatment of PTC. However, the clinical application still faces the problem of resistance to BRAF inhibitors (BRAFi). Therefore, exploring BRAFV600E-associated prognostic factors to providing...
Li, Huali Yang, Chao Cheng, Huangrong Huang, Shuoyang Zheng, Yongbin
Published in
Journal of Cancer
Chimeric antigen receptor-T (CAR-T) cell immunotherapy is a novel method that is genetically engineered to recruit T cells against malignant disease. Administration of CAR-T cells has led to progress in hematological malignancies, and it has been proposed for solid tumors like colorectal cancer (CRC) for years. However, this method was not living u...
Chao, Guanqun Chen, Xinli Zhang, Shuo
Published in
Journal of Cancer
Objective: Retrospective analysis was used to determine the population diagnosed with EGC, and HP infection was used as the cut-off point to further evaluate the correlation between helicobacter pylori (HP) infection and tumor biological characteristics of early gastric cancer (EGC). Methods: All cases were collected from patients diagnosed with EG...
Zheng, Qiuxian Fu, Qiang Xu, Jia Gu, Xinyu Zhou, Haibo Zhi, Chen
Published in
Journal of Cancer
Background: Recent studies have shown that the transcription factor E2F4 is involved in the progression of various tumors, but its expression and influence on immune cell infiltration and biological functions are largely unknown in hepatocellular carcinoma (HCC). Methods: The Cancer Genome Atlas (TCGA) database, the Tumor Immune Estimation Resource...
Huang, Yu Ge, Wenhao Kong, Yang Ding, Yuan Gao, Bingqiang Qian, Xiaohui Wang, Weilin
Published in
Journal of Cancer
Background: Portal vein embolization (PVE) is performed before major liver resection to increase liver volume remnant, controversy remains on the adverse effect of PVE on liver tumor patients. The current study highlighted the effect of PVE on the degree of hypertrophy of future liver remnant (FLR) and summarized PVE-related complications, aiming t...
Li, Yanfang Li, Sha Zhang, Yizhou Shi, Shuhong Qin, Shan Wang, Chang Du, Juan Ma, Jingle Chen, Huan Cui, Huixian
...
Published in
Journal of Cancer
Background: Epithelial ovarian cancer (EOC) is one of the most common gynecological cancers with the highest mortality rate. Studies indicate that androgens contribute to initiation or progression of EOC through poorly understood mechanisms, however, in the phase II clinical studies of antiandrogen therapy for EOC, neither flutamide nor bicalutamid...
Duan, Ning Zhang, Wentao Li, Zhong Sun, Liang Song, Tao Yu, Zirui Chen, Xun Ma, Wei
Published in
Journal of Cancer
Decreased expression of proapoptotic genes can lead to the chemoresistenance in cancer therapy. Carboxyl-terminal binding protein 1 (CtBP1), a transcriptional corepressor with multiple oncogenic effects, has been previously identified to suppress the expression of two proapoptotic genes [ BAX (BCL2 associated X) and BIM (Bcl-2 interacting mediator ...
Wang, Rongjiang Tang, Jianer Chen, Yu Fang, Zhihai Shen, Junwen
Published in
Journal of Cancer
Objective: We demonstrated the potential clinical utility of the indocyanine green (ICG) fluorescence navigation system for laparoscopic partial nephrectomy in the case of complex renal clear cell carcinoma (R.E.N.A.L score ≥7). Methods: Compared with the general laparoscopic partial nephrectomy and ICG fluorescence laparoscopic partial nephrectomy...
Wang, Yan-li Gong, Yuehua Lv, Zhi Li, Liang Yuan, Yuan
Published in
Journal of Cancer
Objective: The microsatellite status and tumor immune microenvironment have a remarkable influence on tumor immunotherapy. This study was performed to investigate programmed cell death protein 1/programmed death ligand 1 (PD1/PDL1) expression and their correlations with CD8+ T cell/CD68+ macrophage (CD68+ M) densities in gastric cancer (GC) at diff...
