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The Effect of Fall Biomechanics on Risk for Hip Fracture in Older Adults: A Cohort Study of Video-Captured Falls in Long...

Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Over 95% of hip fractures in older adults are caused by falls, yet only 1% to 2% of falls result in hip fracture. Our current understanding of the types of falls that lead to hip fracture is based on reports by the faller or witness. We analyzed videos of real-life falls in long-term care to provide objective evidence on the factors that separate f...

Cortical Bone Porosity in Rabbit Models of Osteoporosis

Published in Journal of Bone and Mineral Research

Cortical bone porosity is intimately linked with remodeling, is of growing clinical interest, and is increasingly accessible by imaging. Thus, the potential of animal models of osteoporosis (OP) to provide a platform for studying how porosity develops and responds to interventions is tremendous. To date, rabbit models of OP have largely focused on ...

Incidence of Fractures Before and After Dialysis Initiation

Published in Journal of Bone and Mineral Research

Fractures are common in dialysis patients, but little is known about the trajectory of incidence rates of different types of fractures before and after dialysis initiation. To address this, we investigated the incidence of major fractures before and after dialysis initiation. We performed a retrospective statistical analysis using the Swedish Renal...

Exome Sequencing Reveals a Phenotype Modifying Variant in ZNF528 in Primary Osteoporosis With a COL1A2 Deletion

Published in Journal of Bone and Mineral Research

We studied a family with severe primary osteoporosis carrying a heterozygous p.Arg8Phefs*14 deletion in COL1A2, leading to haploinsufficiency. Three affected individuals carried the mutation and presented nearly identical spinal fractures but lacked other typical features of either osteogenesis imperfecta or Ehlers‐Danlos syndrome. Although mutatio...

Reply to Corticosteroid‐Induced Osteonecrosis in COVID ‐19: A Call for Caution

Published in Journal of Bone and Mineral Research

A Drug Holiday Reduces the Frequency and Severity of Medication‐Related Osteonecrosis of the Jaw in a Minipig Model

Published in Journal of Bone and Mineral Research

Treatment of medication‐related osteonecrosis of the jaw (MRONJ) is challenging and no clear consensus has been achieved. This study investigated preventive measures recommended for tooth extractions under antiresorptive (AR) treatment and the role of discontinuation of AR therapy to avoid the onset of MRONJ in a minipig model. Thirty‐six Göttingen...

Runx2 Regulates Mouse Tooth Root Development Via Activation of WNT Inhibitor NOTUM

Published in Journal of Bone and Mineral Research

Progenitor cells are crucial in controlling organ morphogenesis. Tooth development is a well‐established model for investigating the molecular and cellular mechanisms that regulate organogenesis. Despite advances in our understanding of how tooth crown formation is regulated, we have limited understanding of tooth root development. Runt‐related tra...

LPS ‐Induced Inflammation Prior to Injury Exacerbates the Development of Post‐Traumatic Osteoarthritis in Mice

Published in Journal of Bone and Mineral Research

Osteoarthritis (OA) is a debilitating and painful disease characterized by the progressive loss of articular cartilage. Post‐traumatic osteoarthritis (PTOA) is an injury‐induced type of OA that persists in an asymptomatic phase for years before it becomes diagnosed in ~50% of injured individuals. Although PTOA is not classified as an inflammatory d...

Gene‐Metabolite Network Linked to Inhibited Bioenergetics in Association With Spaceflight‐Induced Loss of Male Mouse Qua...

Published in Journal of Bone and Mineral Research

Prolonged residence of mice in spaceflight is a scientifically robust and ethically ratified model of muscle atrophy caused by continued unloading. Under the Rodent Research Program of the National Aeronautics and Space Administration (NASA), we assayed the large‐scale mRNA and metabolomic perturbations in the quadriceps of C57BL/6j male mice that ...

Corticosteroids‐induced osteonecrosis in COVID ‐19: a call for caution

Published in Journal of Bone and Mineral Research