Reply to Corticosteroid‐Induced Osteonecrosis in COVID ‐19: A Call for Caution
Published in Journal of Bone and Mineral Research
Corticosteroids‐induced osteonecrosis in COVID ‐19: a call for caution
Published in Journal of Bone and Mineral Research
Osteoporotic Fractures in the Time of COVID ‐19
Published in Journal of Bone and Mineral Research
Osteoporosis Management in the Era of COVID-19.
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Osteoporosis is a chronic condition that reflects reduced bone strength and an associated increased risk for fracture. As a chronic condition, osteoporosis generally requires sustained medical intervention(s) to limit the risks for additional bone loss, compromise of skeletal integrity, and fracture occurrence. Further complicating this issue is th...
Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Mo...
...Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Biallelic ENPP1 deficiency in humans induces generalized arterial calcification of infancy (GACI) and/or autosomal recessive hypophosphatemic rickets type 2 (ARHR2). The latter is characterized by markedly increased circulating FGF23 levels and renal phosphate wasting, but aberrant skeletal manifestations associated with heterozygous ENPP1 deficien...
Nonremission and Recurrent Tumor-Induced Osteomalacia: A Retrospective Study.
...Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome. It is curable by excision of the causative tumor. However, a few cases may persist or relapse after tumor resection. We aimed to investigate the rate of these events and related factors. We retrospectively studied TIO patients treated with surgery in a tertiary hospital. TIO was es...
A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potenti...
...Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Novel anabolic drug targets are needed to treat osteoporosis. Having established a large national cohort with unexplained high bone mass (HBM), we aimed to identify a novel monogenic cause of HBM and provide insight into a regulatory pathway potentially amenable to therapeutic intervention. We investigated a pedigree with unexplained HBM in whom pr...
Oral Iron for Prevention and Treatment of Rickets and Osteomalacia in Autosomal Dominant Hypophosphatemia
Published in Journal of Bone and Mineral Research
The Associations Between Seven Different Types of Physical Activity and the Incidence of Fracture at Seven Sites in Heal...
Published in Journal of Bone and Mineral Research
There is a paucity of information on associations between specific types of physical activity and fracture risk at different sites in otherwise healthy postmenopausal women. Therefore, we examined risk of fracture at seven different sites associated with seven different types of physical activity in the population‐based prospective UK Million Women...
Regulation of the Bone Vascular Network is Sexually Dimorphic.
...Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Osteoblast (OB) lineage cells are an important source of vascular endothelial growth factor (VEGF), which is critical for bone growth and repair. During bone development, pubertal differences in males and females exist, but little is known about whether VEGF signaling contributes to skeletal sexual dimorphism. We have found that in mice, conditiona...
