Comments on "diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus".
...Published in Journal of Bone and Mineral Research
Once-yearly zoledronic acid and days of disability, bed rest, and back pain: randomized, controlled HORIZON Pivotal Frac...
Published in Journal of Bone and Mineral Research
The objective of this study was to determine the effect of once-yearly zoledronic acid on the number of days of back pain and the number of days of disability (ie, limited activity and bed rest) owing to back pain or fracture in postmenopausal women with osteoporosis. This was a multicenter, randomized, double-blind, placebo-controlled trial in 240...
Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo.
...Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
While the epidermal growth factor receptor (EGFR)-mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions in the development and homeostasis of the skeletal system has been poorly defined. To address its in vivo role, we constructed transgenic and pharmacologic mouse models and use...
Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production.
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Deficiencies in either growth hormone (GH) or insulin-like growth factor 1 (IGF-1) are associated with reductions in bone size during growth in humans and animal models. Liver-specific IGF-1-deficient (LID) mice, which have 75% reductions in serum IGF-1, were created previously to separate the effects of endocrine (serum) IGF-1 from autocrine/parac...
Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence ...
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Use of recombinant insulin-like growth factor 1 (IGF-1) as a treatment for primary IGF-1 deficiency in children has become increasingly common. When untreated, primary IGF-1 deficiency may lead to a range of metabolic disorders, including lipid abnormalities, insulin resistance, and decreased bone density. To date, results of this therapy are consi...
IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study...
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Bone mineral density (BMD) measured at the femoral neck (FN) is the most important risk phenotype for osteoporosis and has been used as a reference standard for describing osteoporosis. The specific genes influencing FN BMD remain largely unknown. To identify such genes, we first performed a genome-wide association (GWA) analysis for FN BMD in a di...
Impaired osteoblast function in GPRC6A null mice.
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
GPRC6A is a widely expressed orphan G protein-coupled receptor that senses extracellular amino acids, osteocalcin, and divalent cations in vitro. GPRC6A null (GPRC6A(-/-)) mice exhibit multiple metabolic abnormalities including osteopenia. To investigate whether the osseous abnormalities are a direct function of GPRC6A in osteoblasts, we examined t...
Age-dependence of femoral strength in white women and men.
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Although age-related variations in areal bone mineral density (aBMD) and the prevalence of osteoporosis have been well characterized, there is a paucity of data on femoral strength in the population. Addressing this issue, we used finite-element analysis of quantitative computed tomographic scans to assess femoral strength in an age-stratified coho...
Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles.
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Here, we have studied phosphosubstrate catalysis by osteoblast-derived MVs at physiologic pH, analyzing ...
Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.
Published in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
We previously reported that specific oxysterols stimulate osteogenic differentiation of pluripotent bone marrow stromal cells (MSCs) through activation of hedgehog (Hh) signaling and may serve as potential future therapies for intervention in osteopenia and osteoporosis. In this study we report that the osteogenic oxysterol 20(S)-hydroxycholesterol...
