Nie, Jun-Hua Yang, Tao Li, Hong Ye, Hai-Shan Zhong, Guo-Qing Li, Ting-Ting Zhang, Chi Huang, Wen-Han Xiao, Jin Li, Zhi
...
Published in
Journal of Bone Oncology
Background Drug resistance and the lack of molecular therapeutic target are the main challenges in the management of osteosarcomas (OSs). Identification of novel genetic alteration(s) related with OS recurrence and chemotherapeutic resistance would be of scientific and clinical significance. Methods To identify potential genetic alterations related...
Rajasekaran, Raja Bhaskara Palmer, Antony J.R. Whitwell, Duncan Cosker, Thomas D.A. Pigott, David Zsolt, Orosz Booth, Robert Gibbons, M.R.J.P Carr, Andrew
Published in
Journal of Bone Oncology
Background The efficacy and safety of cell salvage for musculoskeletal sarcoma surgery have not been reported, and concerns over re-infusion of tumour cells remain. This study aims to i) describe the intra-operative blood loss and cell salvage reinfusion volumes for lower limb sarcoma and pelvic sarcoma procedures ii) and explore whether there is e...
Assi, Tarek Kattan, Joseph Nassereddine, Hussein Rassy, Elie Briand, Sylvain Court, Charles Verret, Benjamin Le Cesne, Axel Mir, Olivier
Published in
Journal of Bone Oncology
Periosteal osteosarcoma (PO), an intermediate-grade chondroblastic osteosarcoma (OST) arising from the surface of the bones, is a rare histological subtype among primary bone sarcomas, most commonly diagnosed in young patients. It is characterized by distinct specific radiological and pathological features. The current management strategy is based ...
Clemons, Mark Liu, Michelle Stober, Carol Pond, Gregory Jemaan Alzahrani, Mashari Ong, Michael Ernst, Scott Booth, Christopher Mates, Mihaela Abraham Joy, Anil
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Published in
Journal of Bone Oncology
Background We present the 2-year results of a randomised trial comparing 4- versus 12-weekly bone-targeting agents (BTAs) in patients with bone metastases from breast or castration-resistant prostate cancer (CRPC). Patients and Methods Patients with bone metastases from breast or CRPC, who were going to start or were already receiving BTAs, were ra...
Yoneda, Toshiyuki Hiasa, Masahiro Okui, Tatsuo Hata, Kenji
Published in
Journal of Bone Oncology
Bone is one of the preferential target organs of cancer metastasis. Bone metastasis is associated with various complications, of which bone pain is most common and debilitating. The cancer-associated bone pain (CABP) is induced as a consequence of increased neurogenesis, reprogramming and axonogenesis of sensory nerves (SNs) in harmony with sensiti...
Wang, Yu Herroon, Mackenzie K. Zielske, Steven P. Ellis, Leigh Podgorski, Izabela Taichman, Russell S. Cackowski, Frank C.
Published in
Journal of Bone Oncology
Prostate cancer (PCa) metastasis research has been hamstrung by lack of animal models that closely resemble the disease present in most patients – that metastasize to bone, are dependent on the androgen receptor (AR), and grow in an immune competent host. Here, we adapt the Myc-CaP cell line for use as a PCa androgen dependent, immune competent bon...
Zhang, Lei Xiong, Lu Wu, Li-Mei Shen, Wen-Hui Zhou, Ping Lian, Chen-Lu Zhang, Wen-Tong Wu, San-Gang
Published in
Journal of Bone Oncology
Background Ewing sarcoma (ES) of bone is accounting for the second most common type of primary bone cancer in children and adolescents. However, the patterns of distant metastasis (DM) and the effect of the sites of DM on survival outcomes were not investigated. Aims This study aimed to investigate the patterns of DM and the prognostic factors rela...
Deventer, Niklas Deventer, Nils Gosheger, Georg de Vaal, Marieke Vogt, Bjoern Budny, Tymoteusz
Published in
Journal of Bone Oncology
This review of the literature aims to compare the etiology, the pathogenesis, the clinical diagnostics and the relevant treatment options of two different types of cystic bone lesions: the solitary bone cyst (SBC) and the aneurysmal bone cyst (ABC). Whereas the clinical symptoms and the radiographic appearance can be similar, the diagnostic pathway...
Jiang, Rui Zhang, Ziyan Zhong, Zhiwei Zhang, Chao
Published in
Journal of Bone Oncology
Background Long non-coding RNA (lncRNA) RUSC1-AS1 has been found to modulate several cancers development. In this study, we explored the role of RUSC1-AS1 on osteosarcoma (OS) progression. Methods Quantitative Real-time PCR (qRT-PCR) was conducted to test the relative expression of RUSC1-AS1, Notch1 mRNA and miR-101-3p in OS tissues and adjacent no...
Huang, Bao Jiang, Zenghui Wu, Saishuang Wu, Hao Zhang, Xuyang Chen, Jian Zhao, Fengdong Liu, Junhui
Published in
Journal of Bone Oncology
Calcipressin-1, also known as a regulator of calcineurin 1 (RCAN1), is one of the families of endogenous regulators of calcineurin activation and can specifically constrain the activity of calcineurin, but its function in osteosarcoma is still unknown. Firstly, we examined the protein level of RCAN1 in osteosarcoma specimens was lower than that of ...
