Published in Journal of Biosciences
Subcellular localization prediction of the proteome is one of major goals of large-scale genome or proteome sequencing projects to define the gene functions that could be possible with the help of computational modeling techniques. Previously, different methods have been developed for this purpose using multi-label classification system and achieve...
Published in Journal of Biosciences
Long non-coding RNAs (lncRNAs) cancer susceptibility candidate 2 (CASC2) has been characterized as a tumor suppressor in glioma. Although CASC2 may predict the prognosis of glioma patients, the role and mechanism of CASC2 in human glioblastoma remain to be fully illuminated. Expression of CASC2 and miR-18a was detected using RT-qPCR. Cell growth wa...
Published in Journal of Biosciences
Endometriosis is a common disorder of unknown etiology, and non-surgical therapies are still a challenge. To understand the pathogenesis and preclinical testing of drugs for endometriosis, animal models are highly desirous. Herein, we carried out longitudinal characterization of a mouse model for endometriosis where uterine tissue was transplanted ...
Published in Journal of Biosciences
In this study we have investigated the effects of a tumour suppressor microRNA, miR-214, on gene expression in HPV-positive (CaSki) and HPV-negative cervical cancer cells (C33A) by RNA sequencing using next generation sequencing. The HPV-positive and HPV-negative cervical cancer cells were either miR-214-knocked-out or miR-214-overexpressed. Gene e...
Published in Journal of Biosciences
Senescence is an internally systematized degeneration process leading to death in plants. Leaf yellowing, one of the most prominent features of plant aging may lead to reduced crop yields. The molecular mechanism of responses to senescence in soybean leaves is not completely clear. In our research, two soybean varieties were selected with different...
Published in Journal of Biosciences
Shade indicates decreased sunlight. The agricultural importance of shade imparts to its deteriorative effect of crop yield. Rice is not only the most widely used food crop by a third of the population of the world, but it has also been established as the model monocot plant for study. This article describes several important aspects of shade on ric...
Published in Journal of Biosciences
Glioma is one of the most aggressive forms of brain tumor and is hallmarked by high rate of mortality, metastasis and drug resistance. Herein, we explore the role of circular RNA (circRNA) hsa_circ_0000936 in the resistance of glioma cells to temozolomide (TMZ). In this study, Relative changes in gene expression levels were compared using qRT-PCR. ...
Published in Journal of Biosciences
The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses...
Published in Journal of Biosciences
The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The larg...
Published in Journal of Biosciences
Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent progenitor cells of mesodermal origin possessing multilineage differentiation potential and ease of expansion in vitro. Over the years, these cells have gained attention owing to their potential in cell-based therapies in treating various diseases. In particular, the wide spectrum of immu...
