Unni, Sruthi Aouti, Snehal Thiyagarajan, Saravanamuthu Padmanabhan, Balasundaram
Published in
Journal of Biosciences
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is an emerging new viral pathogen that causes severe respiratory disease. SARS-CoV-2 is responsible for the outbreak of COVID-19 pandemic worldwide. As there are no confirmed antiviral drugs or vaccines currently available for the treatment of COVID-19, discovering potent inhibitors or vacc...
Witham, Claire L. Wang, Minyan Baker, Stuart N.
Published in
Frontiers in Systems Neuroscience
Corticomuscular coherence has previously been reported between primary motor cortex (M1) and contralateral muscles. We examined whether such coherence could also be seen from somatosensory areas. Local field potentials (LFPs) were recorded from primary somatosensory cortex (S1; areas 3a and 2) and posterior parietal cortex (PPC; area 5) simultaneou...
Sharma, Abhishek Tiwari, Vikas Sowdhamini, Ramanathan
Published in
Journal of Biosciences
The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses...
Jia, Tony Z Wang, Po-Hsiang Niwa, Tatsuya Mamajanov, Irena
Published in
Journal of Biosciences
One aspect of the study of the origins of life focuses on how primitive chemistries assembled into the first cells on Earth and how these primitive cells evolved into modern cells. Membraneless droplets generated from liquid-liquid phase separation (LLPS) are one potential primitive cell-like compartment; current research in origins of life include...
Ptak, Radek Linden, Martial Van der Schnider, Armin
Published in
Frontiers in Human Neuroscience
Memory disorders are among the most frequent and most debilitating cognitive impairments following acquired brain damage. Cognitive remediation strategies attempt to restore lost memory capacity, provide compensatory techniques or teach the use of external memory aids. Memory rehabilitation has strongly been influenced by memory theory, and the int...
Patwardhan, Raghavendra S Kundu, Kshama Purohit, Vaitashi Kumar, Binita Kislay Singh, Beena Thoh, Maikho Undavia, Khushboo Bhilwade, Hari N Nayak, Sandip K Sharma, Deepak
...
Published in
Journal of Biosciences
The present study primarily focuses on the efficacy of Malabaricone C (Mal C) as an anti-inflammatory agent. Mal C inhibited mitogen-induced T-cell proliferation and cytokine secretion. Mal C significantly reduced cellular thiols in lymphocytes. N -acetyl cysteine (NAC) restored cellular thiol levels and abrogated Mal C-mediated inhibition of T-cel...
Arora, Shashank Rana, Mausam Sachdev, Ananya D’Souza, Jacinta S
Published in
Journal of Biosciences
The past few decades have seen a rise in research on vertebrate cilia and ciliopathy, with interesting collaborations between basic and clinical scientists. This work includes studies on ciliary architecture, composition, evolution, and organelle generation and its biological role. The human body has cells that harbour any of the following four typ...
Karjee, Sumona Mukherjee, Sunil Kumar
Published in
Journal of Biosciences
The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The larg...
Puri, Madhu Brar, Harsimran Kaur Mittal, Nimisha Madan, Evanka Srinivasan, Rajesh Rawat, Kapil Moulik, Srija Chatterjee, Mitali Gorthi, Sai Siva Muthuswami, Rohini
...
Published in
Journal of Biosciences
L. donovani is an intracellular protozoan parasite, that causes visceral leishmaniasis (VL), and consequently, post-kala azar dermal leishmaniasis (PKDL). Diagnosis and treatment of leishmaniasis is crucial for decreasing its transmission. Various diagnostic techniques like microscopy, enzyme-linked immunosorbent assays (ELISA) and PCR-based method...
Deb, Bijayeeta Vilvadrinath, Ramya Goel, Suchi
Published in
Journal of Biosciences
The COVID-19 pandemic that emerged around December 2019 claimed millions of lives. For vaccine development, S protein on viral envelope that binds to ACE2 receptor on cells for entry was identified as vaccine candidate. S protein consists of Receptor Binding Motif (RBM) in the S1 subunit followed by the S2 subunit with an intermediate furin cleavag...
