Published in Journal of biomedical optics
SignificanceMalignant skin tumors, which include melanoma and nonmelanoma skin cancers, are the most prevalent type of malignant tumor. Gross pathology of pigmented skin lesions (PSL) remains manual, time-consuming, and heavily dependent on the expertise of the medical personnel. Hyperspectral imaging (HSI) can assist in the detection of tumors and...
Published in Journal of biomedical optics
Coronary heart disease has the highest rate of death and morbidity in the Western world. Atherosclerosis is an asymptomatic condition that is considered the primary cause of cardiovascular diseases. The accumulation of low-density lipoprotein triggers an inflammatory process in focal areas of arteries, which leads to the formation of plaques. Lipid...
Published in Journal of Biomedical Optics
Significance Water and lipid are key participants of many biological processes, but there are few label-free, non-contact optical methods that can spatially map these components in-vivo . Shortwave infrared meso-patterned imaging (SWIR-MPI) is an emerging technique that successfully addresses this need. However, it requires a dedicated SWIR camera ...
Published in Journal of Biomedical Optics
Significance Deep-imaging of cerebral vessels and accurate organizational characterization are vital to understanding the relationship between tissue structure and function. Aim We aim at large-depth imaging of the mouse brain vessels based on aggregation-induced emission luminogens (AIEgens), and we create a new algorithm to characterize the spati...
Published in Journal of Biomedical Optics
Significance The increase in root caries is a serious problem as society ages. Root caries is diagnosed by inspection and palpation, which are qualitative. A method to objectively and quantitatively evaluate the progress of root caries in a clinical setting is strongly desired. The root caries could be diagnosed by measuring hardness because dentin...
Published in Journal of Biomedical Optics
Significance The water and lipid content of normal breast tissue showed mammary gland characteristics with less influence from the chest wall using six-wavelength time-domain diffuse optical spectroscopy (TD-DOS) in a reflectance geometry. Aim To determine the depth sensitivity of a six-wavelength TD-DOS system and evaluate whether the optical para...
Published in Journal of Biomedical Optics
Significance Lymphatic and peripheral nervous system imaging is of prime importance for monitoring various important pathologic processes including cancer development and metastasis, and response to therapy. Aim Optical coherence tomography (OCT) is a promising approach for this imaging task but is challenged by the near-transparent nature of these...
Published in Journal of Biomedical Optics
Significance Spectroscopic and structural imaging of tissue layers is important for investigating tissue health. However, investigating superficial tissue is difficult using optical imaging, due to the convolved absorption and backscatter of light from deeper layers. Aim This report investigates the effects of hydration and desiccation of ex vivo p...
Published in Journal of Biomedical Optics
Significance Hypoxia imaging for surgical guidance has never been possible, yet it is well known that most tumors have microregional chronic and/or cycling hypoxia present as well as chaotic blood flow. The ability to image oxygen partial pressure ( pO 2 ) is therefore a unique control of tissue metabolism and can be used in a range of disease appl...
Published in Journal of Biomedical Optics
Significance: Quantitative optoacoustic imaging (QOAI) continues to be a challenge due to the influence of nonlinear optical fluence distribution, which distorts the optoacoustic image representation. Nonlinear optical fluence correction in OA imaging is highly ill-posed, leading to the inaccurate recovery of optical absorption maps. This work aims...
