Publication search

Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiati...

Published in Journal of biomedical materials research. Part A

Mesenchymal stem cells (MSCs) are promising for the regeneration of tendon and ligament tissues. Toward realizing this potential, microenvironment conditions are needed for promoting robust lineage-specific differentiation into tenocytes/ligament fibroblasts. Here, we utilized a statistical design of experiments approach to examine combinations of ...

Enhancing neuronal growth from human endometrial stem cells derived neuron-like cells in three-dimensional fibrin gel fo...

Published in Journal of Biomedical Materials Research Part A

Nerve tissue engineering (NTE) is one of the most promising methods to restore central nerve systems in human health care. Three-dimensional (3D) distribution and growth of cells within the porous scaffold composed of nanofibers are of clinical significance for NTE. In this study, an attempt was made to develop and characterize the use of fibrin ge...

Characterizing Accelerated Capture of Deoligomerized TNF within Hemoadsorption Beads Used to Treat Sepsis

Published in Journal of Biomedical Materials Research Part A

Stiffness of the substrate influences the phenotype of embryonic chicken cardiac myocytes

Published in Journal of Biomedical Materials Research Part A

Benzylaminated dextran-modified hydrogels: a long-term bioactive TGF-beta1 carrier.

Published in Journal of Biomedical Materials Research Part A

Highly porous dextran-based hydrogels [in which various amounts (up to 16.6%, w/w) of a benzylaminated dextran (DMCB) exhibiting high affinity for TGFbeta1 was immobilized] were developed to achieve long-term retention of bioactive TGFbeta1 in situ. Unmodified hydrogels rapidly desorbed 80-90% compared with only 40-60% of the preloaded TGFbeta1 fro...

Enhancement of the biological activity of BMP-2 by synthetic dextran derivatives.

Published in Journal of Biomedical Materials Research Part A

In the present study, we explored the binding capacity of synthetic heparin-like dextran derivatives to recombinant human bone morphogenetic protein 2 (BMP-2), a heparin-binding osteoinductive growth factor. Affinity electrophoresis analysis provided evidence that carboxymethylated dextran polymers grafted with high amounts of benzylamide groups (n...

Cationized pullulan 3D matrices as new materials for gene transfer.

Published in Journal of Biomedical Materials Research Part A

This study deals with the development of a novel biocompatible cationized pullulan three-dimensional matrix for gene delivery. A water-soluble cationic polysaccharide, diethylaminoethyl-pullulan (DEAE-pullulan), was first synthesized and characterized. Fluorescence quenching and gel retardation assays evidenced the complexation in solution of DNA w...

Direct correlation between adsorption-induced changes in protein structure and platelet adhesion.

Published in Journal of Biomedical Materials Research Part A

It is widely recognized that adsorbed proteins on biomaterial surfaces tend to initiate thrombus formation, although the specific mechanisms involved are still not well understood. In attempts to decrease the conformational change of adsorbed proteins, surface treatments that reduce surface hydrophobicity have been considered, such as the sulfonati...

Novel poly(ethylene-co-acrylic acid) nanofibrous biomaterials for peptide synthesis and biomedical applications.

Published in Journal of Biomedical Materials Research Part A

Poly(ethylene-co-acrylic acid) (PE-co-AA) fibers in sizes of 200-500 nm were prepared by using a novel melt-extrusion-extraction fabrication process. The thermoplastic nanofibers could be controllably dispersed and reassembled by a novel solvent exchange filtration method. The dispersed PE-co-AA nanofibers possess active surface areas and could dir...