In the present paper, a fluid-structure interaction model is developed, questioning how the mechanical action of the blood onto an atheromatous plaque is affected by the length and the severity of the stenosis. An axisymmetric model is considered. The fluid is assumed Newtonian. The plaque is modelled as a heterogeneous hyperelastic anisotropic sol...
Published in Journal of Biomechanics
Abstract Despite pressing needs, there are currently no FDA approved prosthetic valves available for use in the pediatric population. This study is performed for predictive assessment of blood damage in bileaflet mechanical heart valves (BMHVs) with pediatric sizing and flow conditions. A model of an adult-sized 23mm St. Jude Medical (SJM) Regent™ ...
Published in Journal of Biomechanics
Abstract In the pediatric shoulder, injury and pathology can disrupt the muscle force balance, resulting in severe functional losses. As little data exists pertaining to in vivo pediatric shoulder muscle function, musculoskeletal data are crucially needed to advance the treatment of pediatric shoulder pathology/injury. Therefore, the purpose of thi...
Published in Journal of Biomechanics
Abstract Improving tendon repair using Functional Tissue Engineering (FTE) principles has been the focus of our laboratory over the last decade. Although our primary goals were initially focused only on mechanical outcomes, we are now carefully assessing the biological properties of our tissue-engineered tendon repairs so as to link biological infl...
Published in Journal of biomechanics
Elastically-suspended loads have been shown to reduce the peak forces acting on the body while walking with a load when the suspension stiffness and damping are minimized. However, it is not well understood how elastically-suspended loads can affect the energetic cost of walking. Prior work shows that elastically suspending a load can yield either ...
Published in Journal of biomechanics
The purpose of this study is to estimate the remodelling characteristics of STA-MCA bypass and its influence on patency via the use of computational fluid dynamic (CFD) technology. The reconstructed three-dimensional geometries from MRA were segmented to create computational domains for CFD simulations. Eleven patients, who underwent regular MRA bo...
Published in Journal of biomechanics
Osteocytes, positioned within bone׳s porous structure, are subject to interstitial fluid flow upon whole bone loading. Such fluid flow is widely theorized to be a mechanical signal transduced by osteocytes, initiating a poorly understood cascade of signaling events mediating bone adaptation to mechanical load. The objective of this study was to exa...
Published in Journal of biomechanics
Osteoporosis is a bone disease resulting in increased fracture risk as a result of alterations in both quantity and quality of bone. Bone quality is a combination of metabolic and microarchitectural properties of bone that can help to explain the increased susceptibility to fracture. Translational animal models are essential to understanding the pa...
Published in Journal of biomechanics
The considerable blood mixing in the bidirectional Glenn (BDG) physiology further limits the capacity of the single working ventricle to pump enough oxygenated blood to the circulatory system. This condition is exacerbated under severe conditions such as physical activity or high altitude. In this study, the effect of high altitude exposure on hemo...
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