Soto-Mercado, Viviana Mendivil-Perez, Miguel Jimenez-Del-Rio, Marlene Velez-Pardo, Carlos
Published in
Journal of Alzheimer's disease : JAD
Alzheimer's disease (AD) is characterized by structural damage, death, and functional disruption of cholinergic neurons (ChNs) as a result of intracellular amyloid-β (Aβ) aggregation, extracellular neuritic plaques, and hyperphosphorylation of protein tau (p-Tau) overtime. To evaluate the effect of the synthetic cannabinoid CP55940 (CP) on PSEN1 E2...
Ibanez, Agustin Parra, Mario A Butler, Christopher
Published in
Journal of Alzheimer's disease : JAD
In comparison with other regions, dementia prevalence in Latin America is growing rapidly, along with the consequent clinical, social, and economic burden upon patients and their families. The combination of fragile health care systems, large social inequalities, and isolated clinical and research initiatives makes the coordination of efforts imper...
El Haj, Mohamad Moustafa, Ahmed A Gallouj, Karim
Published in
Journal of Alzheimer's disease : JAD
We assessed depression in 72 patients with Alzheimer's disease (AD) who live in retirement homes during the COVID-19-related lockdown. We invited caregivers of 72 patients with AD who live in retirement homes to rate depression in the patients both before and during the lockdown. Analysis demonstrated increased depression in the patients during the...
Schwertner, Emilia Zelic, Renata Secnik, Juraj Johansson, Björn Winblad, Bengt Eriksdotter, Maria Religa, Dorota
Published in
Journal of Alzheimer's disease : JAD
In Sweden, 2,296,000 firearms were legally owned by private persons in 2017 and there were 150,000 persons living with a dementia diagnosis. A proportion of these persons owning a firearm may pose safety concerns. The aim was to describe firearm ownership in persons with dementia in Sweden and examine which characteristics are explaining physicians...
Lukkarinen, Heikki Tesseur, Ina Pemberton, Darrel Van Der Ark, Peter Timmers, Maarten Slemmon, Randy Janssens, Luc Streffer, Johannes Van Nueten, Luc Bottelbergs, Astrid
...
Published in
Journal of Alzheimer's disease : JAD
Longitudinal changes in cerebrospinal fluid (CSF) biomarkers are seldom studied. Furthermore, data on biomarker gradient between lumbar (L-) and ventricular (V-) compartments seems to be discordant. To examine alteration of CSF biomarkers reflecting Alzheimer's disease (AD)-related amyloid-β (Aβ) aggregation, tau pathology, neurodegeneration, and e...
Poptsi, Eleni Tsolaki, Magda Bergh, Sverre Cesana, Bruno Mario Ciccone, Alfonso Fabbo, Andrea Frisoni, Giovanni B Frölich, Lutz Lavolpe, Sara Guazzarini, Anna Giulia
...
Published in
Journal of Alzheimer's disease : JAD
Behavioral and psychological symptoms of dementia (BPSD) are quite challenging problems during the dementia course. Special Care Units for people with dementia (PwD) and BPSD (SCU-B) are residential medical structures, where BPSD patients are temporarily admitted, in case of unmanageable behavioral disturbances at home. RECage (REspectful Caring fo...
Pagen, Linda H G Smeets, Tom Schmiedek, Lisa Yassa, Michael A Verhey, Frans R J Jacobs, Heidi I L
Published in
Journal of Alzheimer's disease : JAD
Reductions in memory practice effects have gained interest as risk factor for future cognitive decline. Practice effects vary with age and can be moderated by factors such as individual variability in arousal or stress experience acting as an additional cognitive load. In the current pilot study, we examined whether sympathetic nervous system activ...
Surya Tjahyo, Alvin Gandy, Joan Porter, Judi Henry, Christiani Jeyakumar
Published in
Journal of Alzheimer's disease : JAD
Weight loss, a hallmark feature of dementia, is associated with higher mortality in older people. However, there is a lack of consensus in the literature as to whether the weight loss commonly observed in older people with dementia results from reduced energy intake and/or increased energy expenditure. Understanding the cause of energy imbalance in...
Graff-Radford, Jonathan Lesnick, Timothy G Mielke, Michelle M Constantopoulos, Eleni Rabinstein, Alejandro Przybelski, Scott A Vemuri, Prashanthi Botha, Hugo Jones, David T Ramanan, Vijay K
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Published in
Journal of Alzheimer's disease : JAD
The relationship between cerebral microbleeds (CMBs) on hemosiderin-sensitive MRI sequences and cerebral amyloid angiopathy (CAA) remains unclear in population-based participants or in individuals with dementia. To determine whether CMBs on antemortem MRI correlate with CAA. We reviewed 54 consecutive participants with antemortem T2 *GRE-MRI sequen...
Dias, Irundika H K Griffiths, Helen R
Published in
Journal of Alzheimer's disease : JAD
Neuroinflammation has been implicated in Alzheimer's disease onset and progression. Chronic neuroinflammation is initiated by amyloid-β-activated microglial cells that secrete immuno-modulatory molecules within the brain and into the vasculature. Inflammation is normally self-limiting and actively resolves by "switching off" the generation of pro-i...
