Musa, Gada Slachevsky, Andrea Muñoz-Neira, Carlos Méndez, Carolina Villagra, Roque González-Billault, Christian Ibáñez, Agustín Hornberger, Michael Lillo, Patricia
Published in
Journal of Alzheimer's disease : JAD
Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are the most common neurodegenerative early-onset dementias. Despite the fact that both conditions have a very distinctive clinical pattern, they present with an overlap in their cognitive and behavioral features that may lead to misdiagnosis or delay in diagnosis. The current review intend...
James, Hailey J. Van Houtven, Courtney Harold Lippmann, Steven Burke, James R. Shepherd-Banigan, Megan Belanger, Emmanuelle Wetle, Terrie Fox Plassman, Brenda L.
Published in
Journal of Alzheimer's disease : JAD
Background: Amyloid-β PET scans will likely become an integral part of the diagnostic evaluation for Alzheimer’s disease if Medicare approves reimbursement for the scans. However, little is known about patients’ and their care partners’ interpretation of scan results. Objective: This study seeks to understand how accurately patients with mild cogni...
Newkirk, Lori A Dao, Virginia L Jordan, Joshua T Alving, Loren I Davies, Helen D Hewett, Linda Beaudreau, Sherry A Schneider, Logan D Gould, Christine E Chick, Christina F
...
Published in
Journal of Alzheimer's disease : JAD
Existing literature on factors associated with supportive care service (SCS) use is limited. A better understanding of these factors could help tailor SCS to the needs of frequent users, as well as facilitate targeted outreach to populations that underutilize available services. To investigate the prevalence of SCS use and to identify factors assoc...
Wisch, Julie K. Roe, Catherine M. Babulal, Ganesh M. Schindler, Suzanne E. Fagan, Anne M. Benzinger, Tammie L. Morris, John C. Ances, Beau M.
Published in
Journal of Alzheimer's disease : JAD
Background Changes in resting state functional connectivity (rs-fc) occur in Alzheimer disease (AD), but few longitudinal rs-fc studies have been performed. Most studies focus on single networks and not a global measure of rs-fc. Although the amyloid tau neurodegeneration (AT(N)) framework is increasingly utilized by the AD community, few studies i...
Arfanakis, Konstantinos Evia, Arnold M. Leurgans, Sue E. Cardoso, Luis F.C. Kulkarni, Arman Alqam, Nabil Lopes, Lucas F. Vieira, Diego Bennett, David A. Schneider, Julie A.
...
Published in
Journal of Alzheimer's disease : JAD
Background: The association of white matter hyperintensities (WMH) with age-related vascular and neurodegenerative pathologies remains incompletely understood. Objective: The objective of this work was to elucidate the neuropathologic correlates of WMH in a large community-based cohort of older adults. Methods: Cerebral hemispheres from 603 communi...
Whitwell, Jennifer L. Tosakulwong, Nirubol Weigand, Stephen D. Graff-Radford, Jonathan Duffy, Joseph R. Clark, Heather M. Machulda, Mary M. Botha, Hugo Utianski, Rene L. Schwarz, Christopher G.
...
Published in
Journal of Alzheimer's disease : JAD
Background: Rates of beta-amyloid (Aβ) accumulation have been characterized across the cognitively normal to typical Alzheimer’s dementia spectrum, but little is known about Aβ accumulation in atypical Alzheimer’s disease (AD) and other neurodegenerative diseases, such as frontotemporal lobar degeneration (FTLD). We aimed to characterize longitudin...
Tomaszewski, Natalie He, Xulei Solomon, Victoria Lee, Mitchell Mack, Wendy J. Quinn, Joseph F. Braskie, Meredith N. Yassine, Hussein N.
Published in
Journal of Alzheimer's disease : JAD
Background: Docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (AA) play key roles in several metabolic processes relevant to Alzheimer’s disease (AD) pathogenesis and neuroinflammation. Carrying the APOE ε 4 allele ( APOE4 ) accelerates omega-3 polyunsaturated fatty acid (PUFA) oxidation. In a pre-planned subgroup analys...
Dion, Catherine Arias, Franchesca Amini, Shawna Davis, Randall Penney, Dana Libon, David J. Price, Catherine C.
Published in
Journal of Alzheimer's disease : JAD
Background A digital version of the clock drawing test (dCDT) provides new latency and graphomotor behavioral measurements. These variables have yet to be validated with external neuropsychological domains in non-demented adults. Objective The current investigation reports on cognitive constructs associated with selected dCDT latency and graphomoto...
Schelter, Bjoern O Shiells, Helen Baddeley, Thomas C Rubino, Christopher M Ganesan, Harish Hammel, Jeffrey Vuksanovic, Vesna Staff, Roger T Murray, Alison D Bracoud, Luc
...
Published in
Journal of Alzheimer's disease : JAD
Although hydromethylthionine is a potent tau aggregation inhibitor, no difference was found in either of two Phase III trials in mild to moderate Alzheimer's disease (AD) comparing doses in the range 150-250 mg/day with 8 mg/day intended as a control. To determine how drug exposure is related to treatment response. A sensitive plasma assay for the ...
Geier, David A Kern, Janet K Homme, Kristin G Geier, Mark R
Published in
Journal of Alzheimer's disease : JAD
Cognitive health is an emerging public health concern for the aging American population. Mercury (Hg) is a toxic element that can cause nervous system damage. This hypothesis-testing study evaluated the relationship between blood ethyl-Hg levels and cognitive decline in an older adult and elderly American population. A total of 1,821,663 weighted-p...
