Nation, Daniel A Tan, Alick Dutt, Shubir McIntosh, Elissa C Yew, Belinda Ho, Jean K Blanken, Anna E Jang, Jung Yun Rodgers, Kathleen E Gaubert, Aimée
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Published in
Journal of Alzheimer's disease : JAD
Circulating progenitor cells are associated with cognitive impairment, memory, cortical atrophy, and hippocampal perfusion. We hypothesize that progenitor depletion contributes to, or is triggered by, cognitive decline and cortical atrophy. Further study of progenitor cell depletion in older adults may benefit efforts to prevent or delay dementia.
Gleason, Carey E Norton, Derek Anderson, Eric D Wahoske, Michelle Washington, Danielle T Umucu, Emre Koscik, Rebecca L Dowling, N Maritza Johnson, Sterling C Carlsson, Cynthia M
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Published in
Journal of Alzheimer's disease : JAD
These analyses provide preliminary support for IICV as a marker of incident AD and MCI. This easily-disseminated, non-invasive marker compared favorably to well-established CSF biomarkers.
Vasunilashorn, Sarinnapha M Fong, Tamara G Albuquerque, Asha Marcantonio, Edward R Schmitt, Eva M Tommet, Douglas Gou, Yun Travison, Thomas G Jones, Richard N Inouye, Sharon K
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Published in
Journal of Alzheimer's disease : JAD
Patients with the highest delirium severity experienced the greatest rate of cognitive decline, which exceeds the rate previously observed for patients with dementia, on serial neuropsychological testing administered over 3 years, with a dose-response relationship between delirium severity and long-term cognitive decline.
Flanagan, Margaret E Larson, Eric B Walker, Rod L Keene, C Dirk Postupna, Nadia Cholerton, Brenna Sonnen, Joshua A Dublin, Sascha Crane, Paul K Montine, Thomas J
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Published in
Journal of Alzheimer's disease : JAD
Analgesics are commonly used by older adults, raising the question of whether their use might contribute to dementia risk and neuropathologic changes of Alzheimer's disease (AD). The Adult Changes in Thought (ACT) study is a population-based study of brain aging and incident dementia among people 65 years or older who are community dwelling and not...
Dougherty, Ryan J Lindheimer, Jacob B Stegner, Aaron J Van Riper, Stephanie Okonkwo, Ozioma C Cook, Dane B
Published in
Journal of Alzheimer's disease : JAD
Cardiorespiratory fitness (CRF) is routinely investigated in older adults; however, the most appropriate CRF measure to use for this population has received inadequate attention. This study aimed to 1) evaluate the reliability and validity of the oxygen uptake efficiency slope (OUES) as a sub-maximal measurement of CRF; 2) examine demographic, risk...
Robb, Catherine Udeh-Momoh, Chinedu Wagenpfeil, Stefan Schöpe, Jakob Alexopoulos, Panagiotis Perneczky, Robert
Published in
Journal of Alzheimer's disease : JAD
We show that distinct baseline biomarkers may predict latent changes in IADL. Our results necessitate a revision of the commonly held view upholding cognitive changes as the predominant endpoint measure associated with presence of abnormal baseline biomarkers.
Stott, Joshua Scior, Katrina Mandy, William Charlesworth, Georgina
Published in
Journal of Alzheimer's disease : JAD
ACE-III screening accuracy is high and screening performance is robust to variation in premorbid IQ, age, and years of education. Adjustment of ACE-III cut-offs for premorbid IQ is not recommended in clinical practice. The analytic strategy used here may be useful to assess the impact of premorbid IQ on other screening tools.
Craft, Suzanne Claxton, Amy Baker, Laura D Hanson, Angela J Cholerton, Brenna Trittschuh, Emily H Dahl, Deborah Caulder, Erin Neth, Bryan Montine, Thomas J
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Published in
Journal of Alzheimer's disease : JAD
Future research is warranted to examine the mechanistic basis of treatment differences, and to further assess the efficacy and safety of intranasal insulin.
Lopez-Font, Inmaculada Boix, Claudia P Zetterberg, Henrik Blennow, Kaj Sáez-Valero, Javier
Published in
Journal of Alzheimer's disease : JAD
We recently demonstrated that soluble forms of the amyloid-β protein precursor (sAβPP) assemble into multimeric complexes in cerebrospinal fluid (CSF), which contributes to the underestimation of specific sAβPP species when assessed by ELISA. To circumvent this issue, we analyzed by SDS-PAGE large fragments of sAβPP and their variants in the CSF fr...
Anstey, Kaarin J Eramudugolla, Ranmalee Chopra, Sidhant Price, Jasmine Wood, Joanne
Published in
Journal of Alzheimer's disease : JAD
Adults with MCI exhibit a similar range of driving ability to CN adults, although on average they scored lower on off-road and on-road assessments. Driving specific tests were more strongly associated with safety ratings than traditional neuropsychological tests.
