Toepper, Max Schulz, Philipp Beblo, Thomas Driessen, Martin
Published in
Journal of Alzheimer's disease : JAD
On-road driving behavior can be impaired in older drivers and particularly in drivers with mild cognitive impairment (MCI). To determine whether cognitive and non-cognitive risk factors for driving safety may allow an accurate and economic prediction of on-road driving skills, fitness to drive, and prospective accident risk in healthy older drivers...
Si, Zizhen Wang, Xidi
Published in
Journal of Alzheimer's disease : JAD
Alzheimer's disease (AD) is a neurodegenerative disease characterized by complex pathological and biological features. Notably, extracellular amyloid-β deposits as senile plaques and intracellular aggregation of hyperphosphorylated tau as neurofibrillary tangles remain the primary premortem criterion for the diagnosis of AD. Currently, there exist ...
Posada-Duque, Rafael Andrés Cardona-Gómez, Gloria Patricia
Published in
Journal of Alzheimer's disease : JAD
The neurovascular unit (NVU) is responsible for synchronizing the energetic demand, vasodynamic changes, and neurochemical and electrical function of the brain through a closed and interdependent interaction of cell components conforming to brain tissue. In this review, we will focus on cyclin-dependent kinase 5 (CDK5) as a molecular pivot, which p...
Heller, Adam Coffman, Sheryl S Jarvis, Karalee
Published in
Journal of Alzheimer's disease : JAD
Knowing that Alzheimer's disease (AD) nucleates in the entorhinal cortex (EC), samples of 12 EC specimens were probed for crystals by a protocol detecting fewer than 1/5000th of those present. Of the 61 crystals found, 31 were expected and 30 were novel. Twenty-one crystals of iron oxides and 10 atherosclerosis-associated calcium pyrophosphate dihy...
Aksnes, Mari Müller, Ebba Glersen Tiiman, Ann Edwin, Trine Holt Terenius, Lars Revheim, Mona-Elisabeth Vukojević, Vladana Bogdanović, Nenad Knapskog, Anne-Brita
Published in
Journal of Alzheimer's disease : JAD
Aggregation of amyloid-β (Aβ) is an early pathological event in Alzheimer's disease (AD). Consequently, measures of pathogenic aggregated Aβ are attractive biomarkers for AD. Here, we use a recently developed Thioflavin-T-Fluorescence Correlation Spectroscopy (ThT-FCS) assay to quantify structured ThT-responsive protein aggregates, so-called nanopl...
Lamballais, Sander Zijlmans, Jendé L Vernooij, Meike W Ikram, M Kamran Luik, Annemarie I Ikram, M Arfan
Published in
Journal of Alzheimer's disease : JAD
Individual differences in the risk to develop dementia remain poorly understood. These differences may partly be explained through reserve, which is the ability to buffer cognitive decline due to neuropathology and age. To determine how much early and late-life cognitive reserve (CR) and brain reserve (BR) contribute to the risk of dementia. 4,112 ...
Yamamoto, Vicky Bolanos, Joe F Fiallos, John Strand, Susanne E Morris, Kevin Shahrokhinia, Sanam Cushing, Tim R Hopp, Lawrence Tiwari, Ambooj Hariri, Robert
...
Published in
Journal of Alzheimer's disease : JAD
COVID-19 is a severe infectious disease that has claimed >150,000 lives and infected millions in the United States thus far, especially the elderly population. Emerging evidence has shown the virus to cause hemorrhagic and immunologic responses, which impact all organs, including lungs, kidneys, and the brain, as well as extremities. SARS-CoV-2 als...
Hasegawa, Tohru Kosoku, Yoshinori Sano, Yuka Yoshida, Hiroshi Kudoh, Chiaki Tabira, Takeshi
Published in
Journal of Alzheimer's disease : JAD
In the treatment of Alzheimer's disease (AD), it is thought to be most effective to intervene at the earliest and mildest stages. For diagnosis at the earliest and mildest stages, it is desirable to use a biomarker that can be detected by a minimally invasive, cost-effective technique. Recent research indicates the potential clinical usefulness of ...
Monsees, Jessica Schmachtenberg, Tim Hoffmann, Wolfgang Kind, Amy Gilmore-Bykovskyi, Andrea Kim, Alice J Thyrian, Jochen René
Published in
Journal of Alzheimer's disease : JAD
As the proportion of older people with migration background (PwM) increases, the proportion of older PwM with dementia might also increase. Dementia is underdiagnosed in this group and a large proportion of PwM with dementia and family caregivers are not properly supported. Healthcare utilization is lower among older migrant populations. Thus, a be...
de Leeuw, Francisca A Honer, William G Schneider, Julie A Morris, Martha Clare
Published in
Journal of Alzheimer's disease : JAD
Higher vitamin E intake has been widely related to lower risks of cognitive decline and dementia. Animal models suggest that this relationship might be (partially) explained by the protection of vitamin E against presynaptic protein oxidation. In this cross-sectional study, we aimed to examine the associations between brain tocopherols and presynap...
