Heller, Adam Coffman, Sheryl S Jarvis, Karalee
Published in
Journal of Alzheimer's disease : JAD
Knowing that Alzheimer's disease (AD) nucleates in the entorhinal cortex (EC), samples of 12 EC specimens were probed for crystals by a protocol detecting fewer than 1/5000th of those present. Of the 61 crystals found, 31 were expected and 30 were novel. Twenty-one crystals of iron oxides and 10 atherosclerosis-associated calcium pyrophosphate dihy...
Aksnes, Mari Müller, Ebba Glersen Tiiman, Ann Edwin, Trine Holt Terenius, Lars Revheim, Mona-Elisabeth Vukojević, Vladana Bogdanović, Nenad Knapskog, Anne-Brita
Published in
Journal of Alzheimer's disease : JAD
Aggregation of amyloid-β (Aβ) is an early pathological event in Alzheimer's disease (AD). Consequently, measures of pathogenic aggregated Aβ are attractive biomarkers for AD. Here, we use a recently developed Thioflavin-T-Fluorescence Correlation Spectroscopy (ThT-FCS) assay to quantify structured ThT-responsive protein aggregates, so-called nanopl...
Lamballais, Sander Zijlmans, Jendé L Vernooij, Meike W Ikram, M Kamran Luik, Annemarie I Ikram, M Arfan
Published in
Journal of Alzheimer's disease : JAD
Individual differences in the risk to develop dementia remain poorly understood. These differences may partly be explained through reserve, which is the ability to buffer cognitive decline due to neuropathology and age. To determine how much early and late-life cognitive reserve (CR) and brain reserve (BR) contribute to the risk of dementia. 4,112 ...
Yamamoto, Vicky Bolanos, Joe F Fiallos, John Strand, Susanne E Morris, Kevin Shahrokhinia, Sanam Cushing, Tim R Hopp, Lawrence Tiwari, Ambooj Hariri, Robert
...
Published in
Journal of Alzheimer's disease : JAD
COVID-19 is a severe infectious disease that has claimed >150,000 lives and infected millions in the United States thus far, especially the elderly population. Emerging evidence has shown the virus to cause hemorrhagic and immunologic responses, which impact all organs, including lungs, kidneys, and the brain, as well as extremities. SARS-CoV-2 als...
Hasegawa, Tohru Kosoku, Yoshinori Sano, Yuka Yoshida, Hiroshi Kudoh, Chiaki Tabira, Takeshi
Published in
Journal of Alzheimer's disease : JAD
In the treatment of Alzheimer's disease (AD), it is thought to be most effective to intervene at the earliest and mildest stages. For diagnosis at the earliest and mildest stages, it is desirable to use a biomarker that can be detected by a minimally invasive, cost-effective technique. Recent research indicates the potential clinical usefulness of ...
Monsees, Jessica Schmachtenberg, Tim Hoffmann, Wolfgang Kind, Amy Gilmore-Bykovskyi, Andrea Kim, Alice J Thyrian, Jochen René
Published in
Journal of Alzheimer's disease : JAD
As the proportion of older people with migration background (PwM) increases, the proportion of older PwM with dementia might also increase. Dementia is underdiagnosed in this group and a large proportion of PwM with dementia and family caregivers are not properly supported. Healthcare utilization is lower among older migrant populations. Thus, a be...
de Leeuw, Francisca A Honer, William G Schneider, Julie A Morris, Martha Clare
Published in
Journal of Alzheimer's disease : JAD
Higher vitamin E intake has been widely related to lower risks of cognitive decline and dementia. Animal models suggest that this relationship might be (partially) explained by the protection of vitamin E against presynaptic protein oxidation. In this cross-sectional study, we aimed to examine the associations between brain tocopherols and presynap...
Mar, Javier Gorostiza, Ania Ibarrondo, Oliver Cernuda, Carlos Arrospide, Arantzazu Iruin, Álvaro Larrañaga, Igor Tainta, Mikel Ezpeleta, Enaitz Alberdi, Ane
...
Published in
Journal of Alzheimer's disease : JAD
Neuropsychiatric symptoms (NPS) are the leading cause of the social burden of dementia but their role is underestimated. The objective of the study was to validate predictive models to separately identify psychotic and depressive symptoms in patients diagnosed with dementia using clinical databases representing the whole population to inform decisi...
Xiao, Jinzhong Katsumata, Noriko Bernier, Francois Ohno, Kazuya Yamauchi, Yuki Odamaki, Toshitaka Yoshikawa, Kenji Ito, Kumie Kaneko, Toshiyuki
Published in
Journal of Alzheimer's disease : JAD
Probiotics use has been associated with modulation of inflammation and considered as a possible intervention for CNS diseases such as mild cognitive impairment (MCI) and dementia. We aimed to test the effect of the probiotic strain, Bifidobacterium breve A1 (MCC1274), to restore cognition in a physically healthy, suspected MCI population. In this r...
Li, Jingwen Long, Xi Huang, Heqing Tang, Jine Zhu, Chunli Hu, Shaoping Wu, Jing Li, Jinghong Lin, Zhicheng Xiong, Nian
...
Published in
Journal of Alzheimer's disease : JAD
Facing the novel coronavirus disease 2019 (COVID-19), most vulnerable individuals are seniors, especially those with comorbidities. More attention needs to been paid to the COVID-19 patients with Alzheimer's disease (AD), which is the top age-related neurodegenerative disease. Since it is unclear whether AD patients are prone to COVID-19 infection ...
